Transferring embryos with genetic anomalies detected in preimplantation testing: an Ethics Committee Opinion.


:Patient requests for transfer of embryos with genetic anomalies linked to serious health-affecting disorders detected in preimplantation testing are rare but do exist. This Opinion sets out the possible rationales for a provider's decision to assist or decline to assist in such transfers. The Committee concludes in most clinical cases it is ethically permissible to assist or decline to assist in transferring such embryos. In circumstances in which a child is highly likely to be born with a life-threatening condition that causes severe and early debility with no possibility of reasonable function, provider transfer of such embryos is ethically problematic and highly discouraged.


Fertil Steril


Fertility and sterility


Ethics Committee of the American Society for Reproductive Medicine. Electronic address:,Ethics Committee of the American Society for Reproductive Medicine.




Has Abstract


2017-05-01 00:00:00














  • Pelvic adhesions following microsurgical and macrosurgical wedge resection of the ovaries.

    abstract::The incidence of postoperative adhesion formation following microsurgical and macrosurgical ovarian wedge resection was contrasted in 10 adult female rhesus monkeys. Bilateral wedge resection was performed on day 10 of the luteal phase using microsurgical technique on one ovary and macrosurgical technique contralatera...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Eddy CA,Asch RH,Balmaceda JP

    更新日期:1980-05-01 00:00:00

  • Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata.

    abstract::There is a paucity of data concerning the factors involved in the growth of uterine leiomyomata. The expression of mRNAs encoding EGF and the EGF receptor in myometrial and leiomyoma cultures suggest that EGF may be involved in the autocrine/paracrine regulation of human uterine leiomyomata and myometrial growth. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yeh J,Rein M,Nowak R

    更新日期:1991-11-01 00:00:00

  • Effect of T-shaped progesterone-releasing system on contraceptive efficacy and menstrual cycle regularity in Japanese monkeys.

    abstract::Twenty-seven sexually mature Japanese monkeys (Macaca fuscata fuscata) weighing 6 to 8 kg were used to evaluate and characterize the local and systemic effects of a T-shaped progesterone-releasing system (UTS) following transabdominal insertion into the uterus. None of five experimental animals conceived, while four o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Oshima K,Hayashi M,Kato J

    更新日期:1976-05-01 00:00:00

  • Defining embryo donation: an Ethics Committee opinion.

    abstract::Building families through the adoption of children has been supported by human society throughout history. The ethical appropriateness of patients donating embryos to other patients for family building, or for research, is well established and is affirmed by this Committee. The use of the term ''adoption'' for embryos...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引


    authors: Ethics Committee of the American Society for Reproductive Medicine. Electronic address:,Ethics Committee of the American Society for Reproductive Medicine.

    更新日期:2016-07-01 00:00:00

  • Changes in plasma müllerian-inhibiting substance and brain-derived neurotrophic factor after chemotherapy in premenopausal women.

    abstract::Eight premenopausal women with cancer had blood drawn for analysis of brain-derived neurotrophic factor (BDNF) and müllerian-inhibiting substance (MIS) before and 3 months after receiving chemotherapy. Unlike MIS, BDNF levels were not reduced after chemotherapy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Aslam MF,Merhi ZO,Ahmed S,Kuzbari O,Seifer DB,Minkoff H

    更新日期:2011-04-01 00:00:00

  • Live birth is the correct outcome for clinical trials evaluating therapy for the infertile couple.

    abstract::Well-designed and -conducted clinical trials are needed to further advance the field for reproductive medicine. However, current reporting of outcomes of trials is ambiguous and disparate. In this review it is offered that the preferred outcome for clinical trials in reproductive medicine should be live birth. Multipl...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Barnhart KT

    更新日期:2014-05-01 00:00:00

  • Searching for the infertile man with hyperprolactinemia.

    abstract::The purpose of this study was to determine whether routine prolactin measurement was of use when investigating men with infertility. Prolactin levels were slightly higher in men with primary infertility, compared with men with secondary infertility and a fertile control group. Although this slight increase was statist...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hargreave TB,Richmond JD,Liakatas J,Elton RA,Brown NS

    更新日期:1981-11-01 00:00:00

  • The effect of intrauterine devices containing zinc and copper on their levels in serum.

    abstract::Serum levels of copper and zinc were determined in 11 health women in whom Latex Leaf intrauterine devices (IUDs) containing copper and zinc had been inserted. Patients with low levels of serum copper or zinc before insertion usually had increased levels of either of these metals while using the device, but they did n...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Anteby SO,Bassat HA,Yarkoni S,Aboulafia Y,Sadovsky E

    更新日期:1978-01-01 00:00:00

  • Deep endometriosis and bladder and detrusor functions in women without urinary symptoms: a pilot study through an unexplored world.

    abstract:OBJECTIVE:To evaluate the impact of deep endometriosis (DE) on bladder function, focusing on detrusor pattern, in patients without preoperative urinary symptoms. DESIGN:Prospective study. SETTING:Academic research center. PATIENT(S):A total of 25 asymptomatic patients: 12 patients with DE (group 1) and 13 patients w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serati M,Cattoni E,Braga A,Uccella S,Cromi A,Ghezzi F

    更新日期:2013-11-01 00:00:00

  • Different implantation rates after transfers of cryopreserved embryos originating from donated oocytes or from regular in vitro fertilization.

    abstract::Most oocyte donation programs have experienced higher pregnancy rates than usually seen in regular in vitro fertilization (IVF), suggesting that the quality of either the oocytes or the endometrium is superior. To clarify this issue we analyzed the results of transfers of 136 cryopreserved embryos originating either f...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: de Ziegler D,Frydman R

    更新日期:1990-10-01 00:00:00

  • One versus two inseminations per cycle in intrauterine insemination with sperm from patients' husbands: a systematic review of the literature.

    abstract:OBJECTIVE:To study the efficacy of performing two inseminations per cycle in IUI with husband's sperm compared with one insemination per cycle. DESIGN:Meta-analysis. SETTING:Randomized and prospective trials comparing two inseminations vs. one insemination per cycle in IUI with husband's sperm, retrieved by MEDLINE a...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章,meta分析,评审


    authors: Osuna C,Matorras R,Pijoan JI,Rodríguez-Escudero FJ

    更新日期:2004-07-01 00:00:00

  • The follicle-stimulating hormone threshold level for follicle maturation in superovulated cycles.

    abstract:OBJECTIVE:To compare the FSH threshold level for follicle growth up to the preovulatory stage between superovulated and natural cycles. DESIGN:Normally cycling women were investigated during an untreated spontaneous cycle (control) and three cycles treated with FSH. SETTING:Infertility clinic in a university hospital...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lolis DE,Tsolas O,Messinis IE

    更新日期:1995-06-01 00:00:00

  • Hysteroscopic selective salpingography.

    abstract:OBJECTIVE:To evaluate the effectiveness of hysteroscopic selective salpingography (HSS) as a method for diagnosing the tubal proximal occlusion shown by hysterosalpingography (HSG). DESIGN:Prospective study. SETTING:Outpatient Department of Obstetrics and Gynecology, Social Insurance Saitama Chuo Hospital, Urawa, Jap...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Inagaki N,Sato K,Toyoshima K,Ito K,Kitai H,Gabionza DT,Yoshimura Y

    更新日期:1999-10-01 00:00:00

  • Women with reduced ovarian reserve or advanced maternal age have an altered follicular environment.

    abstract:OBJECTIVE:To determine whether altered follicular environment is associated with ovarian reserve or maternal age. DESIGN:Prospective study examining follicular fluid (FF) composition and follicular cell metabolism. SETTING:University research department and private IVF clinic. PATIENT(S):Women (n = 54) undergoing ro...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pacella L,Zander-Fox DL,Armstrong DT,Lane M

    更新日期:2012-10-01 00:00:00

  • Migraine in women with chronic pelvic pain with and without endometriosis.

    abstract:OBJECTIVE:To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis. DESIGN:Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis was diagnosed pathologically. Headaches were classified as migraine or non-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Karp BI,Sinaii N,Nieman LK,Silberstein SD,Stratton P

    更新日期:2011-03-01 00:00:00

  • Prepubertal serum inhibin B in cryptorchid infants and in monorchid boys with compensatory testicular hypertrophy.

    abstract:OBJECTIVE:To investigate the prepubertal serum inhibin B levels in monorchid boys with compensatory testicular hypertrophy (CTH) and in surgically treated cryptorchid boys with normal testicular volume. DESIGN:Prospective study. SETTING:Pediatric Division, University of Verona, Italy. PATIENT(S):Thirty-two prepubert...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Gaudino R,Cavarzere P,Camilot M,Teofoli F,Zampieri N,Tatò L

    更新日期:2008-12-01 00:00:00

  • Development of a rapid, sensitive, and reproducible laboratory test kit for the assessment of plasma membrane integrity of human sperm.

    abstract:OBJECTIVE:To develop a rapid, sensitive, and reproducible hypoosmotic swelling test kit for the assessment of plasma membrane integrity of human sperm in vitro. DESIGN:Prospective comparison of results with the World Health Organization (WHO) method, performed simultaneously. SETTING:Infertility center in a major cit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Misro MM,Chaki SP

    更新日期:2008-01-01 00:00:00

  • Correlation between serum antichlamydial antibodies and tubal factor as a cause of infertility.

    abstract::Although salpingitis frequently produces tubal damage and infertility, many women with tubal factor as a cause of their infertility do not have a clinical history of salpingitis. In order to investigate whether or not some such cases might be due to subclinical chlamydial infections, we measured antichlamydial antibod...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jones RB,Ardery BR,Hui SL,Cleary RE

    更新日期:1982-11-01 00:00:00

  • Combined screening laparoscopy and timed follicle aspiration for human in vitro fertilization.

    abstract::Twenty-seven patients underwent ultrasonographic and clinical monitoring of a spontaneous cycle so that human chorionic gonadotropin administration could be timed in an attempt to schedule the screening laparoscopy at the optimal time for oocyte aspiration. Inadequate ovarian access was encountered in only 2 of 26 lap...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wentz AC,Torbit CA,Daniell JF,Fleischer AC,Garner CH,Pittaway DE,Christianson CD,Repp JE,Maxson WS

    更新日期:1983-03-01 00:00:00

  • In vitro fertilization patients support a single blastocyst transfer policy.

    abstract:OBJECTIVE:To determine whether patients support a mandatory single blastocyst transfer (mSBT) policy in IVF. DESIGN:Prospective survey study. SETTING:Academic hospital-based infertility center. PATIENT(S):Two hundred sixty-two female patients presenting for fresh or cryopreserved/thawed ET after IVF. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Martini S,Van Voorhis BJ,Stegmann BJ,Sparks AE,Shochet T,Zimmerman MB,Ryan GL

    更新日期:2011-10-01 00:00:00

  • Introduction: Continuing story of premature progesterone elevation.

    abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...

    journal_title:Fertility and sterility



    authors: Fanchin R

    更新日期:2018-04-01 00:00:00

  • Buserelin acetate in the treatment of pelvic pain associated with minimal and mild endometriosis: a controlled study.

    abstract:OBJECTIVE:To evaluate the changes of pain symptoms induced by buserelin acetate, a gonadotropin-releasing hormone agonist, in a group of patients with endometriosis. DESIGN:Thirty-five infertile patients with one or more of the following symptoms (dysmenorrhea, pelvic pain, deep dyspareunia, and endometriosis stage I ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fedele L,Bianchi S,Bocciolone L,Di Nola G,Franchi D

    更新日期:1993-03-01 00:00:00

  • Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.

    abstract:OBJECTIVE:To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). DESIGN:Prospective study. SETTING:University medical center. PATIENT(S):Thirty-five patients with PCOS and 31 healthy controls. INTERVENTION(S):Peri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pamuk BO,Torun AN,Kulaksizoglu M,Ertugrul D,Ciftci O,Kulaksizoglu S,Yildirim E,Demirag NG

    更新日期:2010-03-01 00:00:00

  • A mechanism for integrated health care is ideal for women with primary ovarian insufficiency.

    abstract::It is clear that women with primary ovarian insufficiency are asking the health care community to alter the current standard, which requires the patient to seek a different specialist for each of her health care needs, and instead work as a team of caregivers that embraces each patient as a woman with complex and indi...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章


    authors: Sullivan SD

    更新日期:2011-05-01 00:00:00

  • A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata.

    abstract:OBJECTIVE:To determine efficacy and safety of asoprisnil in patients with leiomyomata. DESIGN:Phase 2, multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-group study. SETTING:Twenty-eight sites in the United States and 1 in Canada. PATIENT(S):One hundred twenty-nine women with leiomyoma...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Chwalisz K,Larsen L,Mattia-Goldberg C,Edmonds A,Elger W,Winkel CA

    更新日期:2007-06-01 00:00:00

  • Sonohysterographic screening before in vitro fertilization.

    abstract:OBJECTIVE:To evaluate the use of sonohysterography for uterine screening before IVF. DESIGN:Prospective screening with sonohysterography and comparison with available hysterosalpingographic and hysteroscopic evaluations. SETTING:Private practice. PATIENT(S):Seventy-two women undergoing IVF-ET using their own or dono...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kim AH,McKay H,Keltz MD,Nelson HP,Adamson GD

    更新日期:1998-05-01 00:00:00

  • Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.

    abstract::We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Heilier JF,Donnez O,Van Kerckhove V,Lison D,Donnez J

    更新日期:2006-05-01 00:00:00

  • Hormone pattern after misoprostol administration for a nonviable first-trimester gestation.

    abstract:OBJECTIVE:To evaluate serial hormone concentrations in subjects treated with vaginally administered misoprostol for early pregnancy failure. DESIGN:As part of a randomized clinical trial, serum was collected on treatment days 1, 3, 8, and 15. SETTING:Multicenter clinical trial. PATIENT(S):Women with a nonviable firs...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Barnhart KT,Bader T,Huang X,Frederick MM,Timbers KA,Zhang JJ

    更新日期:2004-04-01 00:00:00

  • Genetic screening of prospective oocyte donors.

    abstract:OBJECTIVE:To report our experience with genetic screening of oocyte donor candidates and to determine the frequency with which significant genetic issues are identified. DESIGN:Prospective genetic screening of oocyte donor candidates. SETTING:University hospital oocyte donation program. PATIENT(S):Women presenting c...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Wallerstein R,Jansen V,Grifo JA,Berkeley AS,Noyes N,Licker J,Licciardi F

    更新日期:1998-07-01 00:00:00

  • Altered ultrastructure of mitochondrial membranes is strongly associated with unexplained asthenozoospermia.

    abstract:OBJECTIVE:To explore the contribution of an altered structure of sperm mitochondria to human asthenozoospermia. DESIGN:A retrospective study. SETTING:Andrology Clinic, University of L'Aquila. PATIENT(S):Fifteen ejaculates with forward motility (FM) ≥ 50%, and 57 asthenozoospermic ejaculates (FM <50%, sperm vitality ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pelliccione F,Micillo A,Cordeschi G,D'Angeli A,Necozione S,Gandini L,Lenzi A,Francavilla F,Francavilla S

    更新日期:2011-02-01 00:00:00