Abstract:
OBJECTIVE:To investigate whether antitrophoblast antibodies are associated with unexplained recurrent miscarriages, we used choriocarcinoma cells JEG-3, since these cells are negative for class I and II antigens, but they do express HLA-G, resembling an antigen expression of endovascular and interstitial trophoblasts. DESIGN:Case-control study. SETTING:Academic research center. PATIENT(S):One hundred ninety-four patients with two or more consecutive, idiopathic recurrent miscarriages (RM; <20 weeks of gestation) were compared with 110 controls with normal pregnancies and without pregnancy complications. INTERVENTION(S):Anti-JEG-3 reactivities were measured by using flow cytometry and comparisons with two in-house standards antibody samples of low and high reactivity. MAIN OUTCOME MEASURE(S):Anti-JEG-3 reactivities above the 95% confidence interval of controls were defined as positive. RESULT(S):Sera of RM patients reacted significantly stronger with JEG-3 cells than that of controls. In addition, RM patients significantly more often had positive anti-JEG-3 reactivities (17.5%) than controls 5%. This difference was markedly increased with a subgroup of 80 RM patients who had three or more miscarriages, as 27 of these women (34%) were anti-JEG-3 positive. CONCLUSION(S):Antitrophoblast antibodies show significantly more mean channel shift reactivities, and positive reactivities are significantly more prevalent in RM patients as compared with controls. Such antibodies may be involved in mechanisms affecting pregnancies.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Rogenhofer N,Ochsenkühn R,von Schönfeldt V,Assef RB,Thaler CJdoi
10.1016/j.fertnstert.2011.11.014subject
Has Abstractpub_date
2012-02-01 00:00:00pages
361-6issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(11)02790-7journal_volume
97pub_type
杂志文章abstract:OBJECTIVE:To examine the expression of the heat shock protein hsp70-2, and the possible relationship with the pathogenesis of male infertility. DESIGN:Prospective study. SETTING:Reproductive testing laboratory in a university hospital. PATIENT(S):Men undergoing testicular biopsy during an investigation of subfertili...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)02892-8
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women. DESIGN:Prospective cohort study. SETTING:University. PATIENT(S):Participants included 259 healthy regularly menstruating women aged 18-44 years. INTERVENTION(S):None...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.002
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether Kremer's sperm-mucus penetration test may predict sperm fertilizing ability in IVF. DESIGN:Kremer's test was prospectively performed on semen samples used for 66 consecutive IVF trials and compared with the fertilization rates and fertilization failure rates observed. RESULTS:Fertiliz...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55981-0
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To describe a patient with primary primitive neuroectodermal tumor of the ovary with two successful spontaneous pregnancies. DESIGN:Case report. SETTING:Tertiary center for gynecologic oncology. PATIENT(S):A 25-year-old woman with two spontaneous pregnancies 5 months after and 2 years after conservative tr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.08.036
更新日期:2004-03-01 00:00:00
abstract::Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals. Patient exposure to toxic environmental chemicals and other stressors is ubiquitous, and preconception and prenatal exposure to toxic environmental agen...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.043
更新日期:2013-10-01 00:00:00
abstract::The reproductive history of 19 women with a diagnosis of unicornuate uterus confirmed by laparoscopy or laparotomy is analyzed. The patients were followed for 2 to 10 years. One patient had a cavitary communicating rudimentary horn, four a cavitary noncommunicating rudimentary horn, seven a noncavitary rudimentary hor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59047-5
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To review selected environmental, occupational, and other important risk factors for the following adverse pregnancy outcomes: low birth weight (LBW), intrauterine growth retardation (IUGR), and preterm delivery (PTD). DESIGN:The evidence is explored in greater detail for environmental tobacco smoke, drinkin...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2007.12.041
更新日期:2008-02-01 00:00:00
abstract::In this observational, case-control study in infertile women, we observed elevated serum oxidative stress that was significantly correlated with an increase in serum paraoxonase-1 activity and without any evidence of a proinflammatory reaction. These results suggest a protective role of paraoxonase-1 against inflammat...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.11.043
更新日期:2010-08-01 00:00:00
abstract::Reportedly, gamete intrafallopian transfer and zygote intrafallopian transfer are successful methods in assisted conception. This pilot study describes the experiences and results of a recently developed technique of vaginal transcervical intrafallopian transfer. In a group of 38 women with unexplained infertility, oo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53704-2
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:To evaluate IVF characteristics and outcome of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma. DESIGN:Observational case series study. SETTING:The Department of Gynecology Oncology and IVF unit of Chaim Sheba Medical center, Tel-Hashomer, Israel. PATIENT(S):Eight ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.01.058
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:The pharmacokinetics of norelgestromin, the primary active metabolite of norgestimate, plus ethinyl estradiol (EE), delivered by the once-weekly contraceptive patch (Ortho Evra/Evra), have been studied in eight trials. This overview summarizes the relevant pharmacokinetic data for the contraceptive patch. DE...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(01)03261-7
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:To compare polyacrylamide gel as synthetic medium with human cervical mucus (CM) for the in vitro sperm-penetration test during infertility investigation. PATIENTS:One hundred sixty-nine randomly chosen couples with a median duration of infertility of 4 (range, 1 to 16) years presenting at the infertility un...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)56174-3
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To describe a 5-year experience of fluoroscopically guided hysteroscopic synechiolysis for Asherman's syndrome. DESIGN:Retrospective, uncontrolled cohort study. SETTING:Department of Endo-Gynaecology, University of New South Wales, Royal Hospital for Women, Randwick, Sydney, New South Wales, Australia. PAT...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.06.035
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To review the current literature on genes known to affect fertility in the human and mouse. DESIGN:A literature review was performed and key articles were chosen for focus in the areas of genes with effects only on spermatogenesis and oogenesis, with an emphasis on Y-chromosome-encoded gene families and sper...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(98)00071-5
更新日期:1998-06-01 00:00:00
abstract::Among 2,245 women, those who experienced a chemical pregnancy that failed to progress to a clinically recognized pregnancy or a spontaneous abortion on their first IVF cycle were more likely to discontinue IVF treatment than those whose first cycle ended before embryo transfer or who did not have a positive pregnancy ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.07.1732
更新日期:2009-04-01 00:00:00
abstract::The usefulness of a short-interval second-look laparoscopy (SLL) after ovarian surgery was examined. In 23 infertile women who had either bilateral wedge resection (BWR) of polycystic ovaries, an oophorocystectomy (OC), or resection of endometriomata (RE), adhesions were graded before and after surgery and before and ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48975-2
更新日期:1985-11-01 00:00:00
abstract:OBJECTIVE:To determine if sperm exposure to P produces an enhancement in its fertilizing capacity. DESIGN:Sperm from fertile donors were exposed to P at 0.1 and 1.0 microgram/mL for 1 or 24 hours. The effects on hyperactivated (HA) motility at 1 and 4 hours, acrosome reaction (as determined by Pisum sativum agglutinin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56051-8
更新日期:1993-07-01 00:00:00
abstract:OBJECTIVE:To determine whether obesity affects serum and seminal measures of male reproductive potential among a multi-institutional cohort. DESIGN:Retrospective multi-institutional cohort study. SETTING:Infertility clinics. PATIENT(S):All men referred for male infertility evaluation from 2002 to 2014 (n = 4,440). ...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2016.06.041
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To present a report on assisted reproductive technologies (ART) cycles performed in 2005 in Canada. This is the fifth annual report from the Canadian ART Register (CARTR). DESIGN:Prospective cohort study. SETTING:Twenty-five of 25 ART centers in Canada. PARTICIPANT(S):Couples undergoing ART treatment in Ca...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.02.125
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To investigate whether bisphenol A (BPA) exposure is associated with uterine decidualization and embryo implantation failure in mice. DESIGN:Experimental animal study and in vitro study. SETTING:University-based infertility center. ANIMAL(S):ICR mice. INTERVENTION(S):Mice treated with different doses of B...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2017.12.003
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:To evaluate correlations between oxygen consumption (OC) measurements before and after embryo cytokinesis, observing OC during embryo cleavages and combining that information with morphokinetics to relate to implantation potential. DESIGN:Prospective cohort study. SETTING:University-affiliated private IVF u...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.03.019
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To determine whether nerve fibers can be detected in the endometrium and myometrium in women with painful uterine fibroids and adenomyosis. DESIGN:A retrospective immunohistochemical study. SETTING:An academic training hospital. PATIENT(S):Thirty-seven women with uterine fibroids and 29 women with adenomyo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.03.026
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To measure activin A concentrations in uterine washing fluid collected from women with couple infertility undergoing intrauterine insemination (IUI). DESIGN:Retrospective case-control study. SETTING:Tertiary university center for women's care. PATIENT(S):Fifty women, of whom 25 became pregnant after up to ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.125
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To examine the effects of soy phytoestrogens on coronary vascular reactivity in atherosclerotic male and female rhesus monkeys. DESIGN:A prospective, randomized, blinded, controlled study. SETTING:Comparative Medicine Clinical Research Center of an academic medical center. PATIENT(S):Twenty-two young adult...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81872-9
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family. DESIGN:Case report. SETTING:Medical Faculty of Cukurova University in Turkey. PATIENT(S):Referred by obstetrics and gynecology clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.02.030
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To study the value of virtual hysterosalpingography (VHSG) in the diagnosis of bicornuate vs. septate uterus. DESIGN:Retrospective study of all cases with bicornuate or septate uterus that had VHSG during the last 3 years at our center. SETTING:Private fertility center and radiology institute with universit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.08.026
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To investigate the use of medroxyprogesterone acetate (MPA) to prevent LH surge during controlled ovarian hyperstimulation (COH) and to compare cycle characteristics and pregnancy outcomes in subsequently frozen-thawed ET (FET) cycles. DESIGN:A prospective controlled study. SETTING:Tertiary-care academic me...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.03.022
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN:Molecular studies in human tissue...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1386
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To study the distribution of a set of polymorphic alleles of genes encoding key regulators of the menstrual cycle in cohorts of women with different levels of fertility. DESIGN:Prospective cohort study. SETTING:University hospital. PATIENT(S):Two hundred fertile women, who reported to have conceived within...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.05.048
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the optimal GnRH agonist dose for triggering of oocyte maturation in oocyte donors. DESIGN:Single-center, randomized, parallel, investigator-blinded trial. SETTING:IVFMD, My Duc Hospital, Ho Chi Minh City, Vietnam. PATIENT(S):One hundred sixty-five oocyte donors (aged 18-35 years, body mass in...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2015.10.014
更新日期:2016-02-01 00:00:00