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Prevention of gestational diabetes by metformin plus diet in patients with polycystic ovary syndrome.

Abstract：

OBJECTIVE:To prospectively assess whether metformin diet safely provides primary and secondary prevention of gestational diabetes (GD). DESIGN:Assess development of GD on metformin diet. SETTING:Outpatient clinical research center. PATIENT(S):One hundred forty-two nondiabetic women with polycystic ovary syndrome (PCOS) who had at least one live-birth (LB) pregnancy on metformin diet (172 pregnancies, 180 LBs). INTERVENTION(S):Women were given 26% protein, 44% carbohydrate diets, without calorie restriction during pregnancy. Metformin (2-2.55 g/d) was given preconception, through pregnancy. MAIN OUTCOME MEASURE(S):Development of GD. RESULT(S):On metformin, GD developed in 12 (7%) of 172 LB pregnancies. Forty-seven women had at least one previous LB pregnancy (n = 64) without metformin, with GD developing in 19 (30%). Subsequently, on metformin, these 47 women had 50 LB pregnancies, developing GD in 6 (12%), which was a statistically significant difference. Of 15 women who had previous GD without metformin, GD developed in 5 (31%) of 16 subsequent pregnancies on metformin. Of 32 women who were previously free of GD without metformin, GD developed in 1 (3%) of 34 subsequent pregnancies on metformin. Previous GD without metformin was the only statistically significant explanatory variable for current GD on metformin. CONCLUSION(S):Metformin diet during pregnancy in women with PCOS facilitates primary and secondary prevention of GD.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Glueck CJ,Pranikoff J,Aregawi D,Wang P

doi

10.1016/j.fertnstert.2007.03.036

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

625-34

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00655-3

journal_volume

89

pub_type

临床试验,杂志文章

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