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A tissue-engineered human endometrial stroma that responds to cues for secretory differentiation, decidualization, and menstruation.

Abstract：

OBJECTIVE:To show the responsiveness of tissue-engineered human endometrial stroma to combinations of hormones that mimic the secretory and menstrual phases of the cycle. DESIGN:In vitro experimental study. SETTING:University uterine biology research laboratory. PATIENT(S):None. INTERVENTION(S):Telomerase immortalized human endometrial stromal cells cultured in monolayers (two-dimensional, 2D) or encapsulated in a collagen I hydrogel (three-dimensional, 3D) to create a simplified tissue-engineered stroma were exposed to hormone treatments mimicking early and late secretory phases, decidualization, and steroid withdrawal conditions to recapitulate menstruation. MAIN OUTCOME MEASURE(S):Morphologic and biochemical markers of decidualization and collagenase activity. RESULT(S):The 3D tissue can manifest changes in morphology and biochemical markers of decidualization similar to 2D culture and characteristic of endometrial stroma in vivo. Unlike 2D culture, the 3D tissue responded to steroid withdrawal by increased collagenase activity and tissue breakdown. CONCLUSION(S):Three-dimensional tissue-engineered endometrial stroma can mimic secretory and menstrual phases of the cycle and may be useful for studying uterine receptivity and menstruation in a physiological endocrine environment.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Schutte SC,Taylor RN

doi

10.1016/j.fertnstert.2012.01.098

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

997-1003

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00127-6

journal_volume

97

pub_type

杂志文章

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