The incidence of sperm-associated immunoglobulin and C3, the third component of complement, in infertile men.

Abstract:

:One hundred four consecutive men who underwent a semen analysis as part of their infertility evaluation were assayed for sperm-associated immunoglobulin (Ig) and the third component of complement (C3). Sixteen (15%) of the 104 men had increased IgG, and 10 (12%) of 86 men tested had increased IgA on their sperm; however, only 4 (5%) of the 87 men tested were positive for plasma IgG antisperm antibody. Only 2 (13%) of the 16 men with increased sperm-associated IgG had detectable IgG antisperm antibodies in their seminal plasma. Five (10%) of 50 men tested had increased sperm-associated C3; none had seminal plasma that deposited C3 on sperm. These data suggest that of the three compartments that can be tested--circulating plasma, seminal plasma, and the sperm surface--the direct measurement of sperm surface Ig may be most important in the evaluation of infertile men. The presence of sperm-associated IgG or IgA was not associated with semen abnormality. In contrast, the presence of sperm-associated IgG was associated with decreased mucus penetration at the time of postcoital testing despite normal-appearing mucus.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Haas GG Jr,Schreiber AD,Blasco L

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

542-7

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)46948-7

journal_volume

39

pub_type

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