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Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Abstract：

OBJECTIVE:To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). DESIGN:Cohort. SETTING:Academic practice. PATIENT(S):A total of 54 anovulatory women with PCOS and 28 age- and weight-matched control subjects. INTERVENTION(S):Blood and ovarian ultrasound at baseline and after 5 years. MAJOR OUTCOME MEASURE(S): Serum antimüllerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound. RESULT(S):After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH ≤ 4 ng/mL was associated with ovulatory function. CONCLUSION(S):Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Carmina E,Campagna AM,Mansuet P,Vitale G,Kort D,Lobo R

doi

10.1016/j.fertnstert.2012.06.017

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1043-6

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(12)00652-8

journal_volume

98

pub_type

杂志文章

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