Abstract:
OBJECTIVE:To measure the level of distress and its relationship with other psychologic factors in women with diminished ovarian reserve (DOR) who participated in a fragile X genetics study. DESIGN:Longitudinal data analyzed with structural equation modeling. SETTING:Four U.S. private and academic fertility centers. PATIENT(S):Sixty-two infertile patients with DOR. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Fertility Problem Inventory, Coping Scale for Infertile Couples, Rosenberg Self-Esteem, Health Orientation Scale. RESULT(S):Nineteen percent had low fertility distress, 56% had average fertility distress, and 24% had high fertility distress. Thirty-six percent self-reported a "favorable" or "very favorable" emotional response to potentially being a fragile X carrier (termed "emotions"), 53% were "ambivalent," and 11% had an unfavorable reaction. Three months after learning that they were not a carrier, these percentages were 91%, 9%, and 0%, respectively. Emotions at this second time point were significantly more positive than at pretesting. At baseline, higher self-esteem was a significant predictor of reduced fertility distress both directly and indirectly through emotions. Fertility distress was not associated with coping. Self-esteem, fertility distress, pretesting emotions, and coping were unrelated to posttesting emotions. CONCLUSION(S):The potential of having an explanation for one's DOR condition may have a beneficial impact on women's psychologic states during the process of genetic testing, and this appeared to be especially true for women with higher self-esteem. Psychologic interventions targeted to women with low self-esteem may reduce distress and improve reactions to genetic testing.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Cizmeli C,Lobel M,Franasiak J,Pastore LMdoi
10.1016/j.fertnstert.2013.02.033subject
Has Abstractpub_date
2013-06-01 00:00:00pages
2037-44.e3issue
7eissn
0015-0282issn
1556-5653pii
S0015-0282(13)00325-7journal_volume
99pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To compare the clinical and endocrinologic effects of cyproterone acetate (CPA), an antiandrogen with progestational activity; flutamide, a nonsteroidal antiandrogen, and finasteride, an inhibitor of 5alpha-reductase. DESIGN:Randomized, open, controlled clinical study. SETTING:Department of Obstetrics and G...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(98)00486-5
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To determine intrafollicular hormone levels and characterize the mRNA expression of the insulin-like growth factor (IGF) receptors, IGF binding proteins (IGFBP), and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells before and after an ovulatory hCG stimulus. DESIGN:Experimental animal study....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.096
更新日期:2010-03-15 00:00:00
abstract:OBJECTIVE:To report the inheritance of a pericentric inversion in chromosome 7 through the three progenies, congenital hydronephrosis, and recurrent miscarriages in an extended family. DESIGN:Case report. SETTING:Medical Faculty of Cukurova University in Turkey. PATIENT(S):Referred by obstetrics and gynecology clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.02.030
更新日期:2008-01-01 00:00:00
abstract::In view of the increasing emphasis being placed on patient safety and quality health care, it is extremely important to develop fail-safe mechanisms to prevent assisted reproductive technology (ART) mix-ups. Sample mismatch is the most undesirable event that can occur in an IVF laboratory as it may have catastrophic c...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2013.09.029
更新日期:2013-12-01 00:00:00
abstract::Intrafollicular insemination is a promising new development that may have a major impact on ART, notably in the treatment of male factor infertility. Reported is the first successful intrafollicular insemination in the United States and the first successful intrafollicular insemination for male factor infertility. Alt...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55191-7
更新日期:1992-08-01 00:00:00
abstract::This retrospective cohort study compared blastocyst transfers in 136 fresh oocyte donor cycles and 69 autologous cycles using blastocysts derived from culture of thawed bipronuclear oocytes, all with oocytes derived from patients or donors less than 35 years old. The autologous cycles and oocyte donor cycles had simil...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.07.966
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To ascertain the extent of phenotypic heterogeneity for premature pubarche and polycystic ovary syndrome between and within families. DESIGN:Association study. SETTING:Academic research environment. PATIENT(S):Three families in which the propositus had presented with either premature pubic hair or adolesce...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03252-1
更新日期:2002-09-01 00:00:00
abstract::Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.10.014
更新日期:2010-07-01 00:00:00
abstract::Total effective estrogenicity of several human oral contraceptives was investigated through a method determining uterine weight in immature rats. The preparations, normally given to human females in tablet, form were Norinyl-1 (.05 mg mestranol, 1mg norethindrone), Norinyl-2 (.10 mg mestranol, 2 mg norethindrone), Ov...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)36671-7
更新日期:1968-05-01 00:00:00
abstract:OBJECTIVE:To review, evaluate, and synthesize current published reports assessing the value of abdominal myomectomy in infertile women and those desiring to preserve fertility potential. DATA IDENTIFICATION:Major studies dealing with myomectomy were identified through Medline Searches. STUDY SELECTION:Those papers re...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)55128-0
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To determine the effects of chilling on the organization and distribution of tubulin and chromosomes in rhesus monkey oocytes. DESIGN:Comparative laboratory study. SETTING:Academic research laboratory. ANIMAL(S):Eight adult female rhesus monkeys (Macaca mulatta) aged 6-16 years. INTERVENTION(S):A total of...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)03240-x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To estimate the association between prenatal exposure to maternal stress and reproductive disorders in Danish men, where prenatal stress exposure was defined as the mother's loss of a close relative during pregnancy or in the 12 months before conception. DESIGN:Population-based cohort study. SETTING:Not app...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2016.10.016
更新日期:2017-01-01 00:00:00
abstract::Hormonal profiles were compared in 14 ovulatory women who were treated with two different doses of gonadotropins in successive in vitro fertilization cycles. All patients suffered from mechanical causes of infertility. Serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and progesterone...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:To assess the relative efficacy, in terms of clinical pregnancy rates (PRs), of transuterotubal insemination versus the more traditional intrauterine insemination (IUI) procedure. DESIGN:Prospective, randomized, cross-over. SETTING:University-affiliated tertiary care center. PATIENTS:One hundred sixty infe...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To investigate relationships between cumulus-oocyte complex (COC) morphology, protein patterns of cumulus-corona (CC) cell-conditioned media, and pregnancy outcome in IVF-ET cycles. DESIGN:Retrospective study. SETTING:Private university IVF center. PATIENT(S):One hundred twenty infertile women who underwen...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01754-x
更新日期:2001-05-01 00:00:00
abstract::Oocytes are complex cells comprising many cellular systems, each of which is essential for proper oocyte function. Methods to assess the diverse and critical cellular systems in oocytes derived from in vitro maturation are badly needed. ...
journal_title:Fertility and sterility
pub_type: 评论,杂志文章,评审
doi:10.1016/j.fertnstert.2005.12.009
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To analyze the data available on the biologic significance of white blood cells (WBC) in semen of infertility patients. DATA RESOURCES:The relevant literature was reviewed. RESULTS:It is not possible to identify reliably WBC by conventional sperm staining techniques. The peroxidase method is sufficient for ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)57588-8
更新日期:1995-06-01 00:00:00
abstract::To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticoste...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47840-4
更新日期:1984-05-01 00:00:00
abstract::Financial compensation to egg donors for their time and inconvenience in donating is established in the United States as ethically and legally acceptable. That system should be extended to egg donation for research. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.08.084
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To investigate whether zona drilling of oocytes, a technique used to locally disrupt the zona pellucida, causes important changes in intracellular pH. DESIGN AND METHODS:In a first set of experiments, intracellular pH was measured during zona drilling of mouse oocytes, using pH-sensitive microelectrodes. In ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56525-x
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:To compare sperm morphology of electrostimulated ejaculates of spinal cord-injured (SCI) men with that of manual ejaculates of an able-bodied population. DESIGN:Retrospective study. PATIENTS:Spinal cord-injured men (n = 21) participating in a reproductive rehabilitation program and able-bodied men (n = 163)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57561-x
更新日期:1995-05-01 00:00:00
abstract::The acrosome reaction of human spermatozoa incubated in the presence or absence of vested human oocytes was investigated. All gametes were obtained from human in vitro fertilization (IVF) cases. Spermatozoa were collected after incubation in insemination medium only and following removal of the oocytes from inseminati...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60379-5
更新日期:1988-12-01 00:00:00
abstract::To explore the relationship between variation in AGT M235T gene and the development of the polycystic ovary syndrome (PCOS) and its sequelae, in the present study we evaluated AGT polymorphism M235T in women with PCOS and in a control group. Moreover, to detect any relationship between AGT M235T variation and intermed...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.05.043
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To assess the direct effects of three endometriosis chemotherapeutic agents (medroxyprogesterone acetate [MPA], danazol, and leuprolide acetate [LA]) on endometrial cell proliferation. DESIGN:Analysis of cell proliferation in vitro. SETTING:Proliferative phase endometrial stromal cells isolated from biopsy ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract:OBJECTIVE:To evaluate prospectively the effects of high-dose, short-term treatment with a glucocorticoid in an attempt to normalize ovarian failure and induce pregnancy in women presenting with infertility. DESIGN:Uncontrolled, nonrandomized prospective study. SETTING:Two university-based reproductive endocrinology c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55915-9
更新日期:1993-05-01 00:00:00
abstract:OBJECTIVE:To investigate the spontaneous variation of leukocytospermia (>1 million/mL) in semen samples from infertile men. DESIGN:Prospective cohort study. SETTING:Andrologic clinic at university hospital. PATIENT(S):Ninety-nine men evaluating for infertility causes. INTERVENTION(S):Two semen analyses according th...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.08.041
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.06.055
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To determine the relative effectiveness of single vs. two transcervical monthly insertions of 252 mg of quinacrine for female sterilization. DESIGN:Controlled clinical study. SETTING:Family planning clinics of 6 academic centers. PATIENT(S):Sexually active reproductive-age women requesting sterilization. ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(02)02957-6
更新日期:2002-05-01 00:00:00
abstract::Daily leukocyte alkaline phosphatase activity (LAP), basal body temperature (BBT), fern test (FT) and serum luteinizing hormone (LH) were determined during 15 normal menstrual cycles and 10 cycles treated with clomiphene citrate. A rise in LAP activity, as determined by LAP-relative score (LAP-RS), was observed durin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)39623-6
更新日期:1973-04-01 00:00:00
abstract:OBJECTIVE:To determine whether men with azoospermia are at an elevated risk of developing cancer in the years following an infertility evaluation. DESIGN:Cohort study. SETTING:United States andrology clinic. PATIENT(S):A total of 2,238 men with complete records were evaluated for infertility at a single andrology cl...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.05.022
更新日期:2013-09-01 00:00:00