Randomized trial of one versus two transcervical insertions of quinacrine pellets for sterilization.


OBJECTIVE:To determine the relative effectiveness of single vs. two transcervical monthly insertions of 252 mg of quinacrine for female sterilization. DESIGN:Controlled clinical study. SETTING:Family planning clinics of 6 academic centers. PATIENT(S):Sexually active reproductive-age women requesting sterilization. INTERVENTION(S):At each of six centers 70 and 30 women were randomly assigned to receive either one or two, respectively, monthly transcervical insertions to the fundus of 252 mg of quinacrine and 75 mg of diclofenac as pellets and they were followed for 1 year. MAIN OUTCOME MEASURE(S):Complications, side effects, and pregnancy failures. RESULT(S):There were no serious complications and side effects were transient and easily treated. There were 31 (7.4%) pregnancy failures in the single insertions group and 2 (1.1%) in the two insertions group, but with marked center variation. CONCLUSION(S):Quinacrine sterilization using two monthly insertions of 252 mg of quinacrine appears safe and reasonably effective.


Fertil Steril


Fertility and sterility


Agoestina T,Hoesni RH,Purwara BH,Santoso BI,Siswanto P,Dasuki D,Samsulhadi A,Surya GP





Has Abstract


2002-05-01 00:00:00














  • European view of subspecialty training on behalf of the European Society of Human Reproduction and Embryology (ESHRE).

    abstract::Specialist training in reproductive medicine within Europe continues to evolve. Recent revisions, updates, and initiatives have helped to refine the core educational needs for the specialist trainee. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Calhaz-Jorge C,Feki A,Farquharson R

    更新日期:2015-07-01 00:00:00

  • Endometrioma-related reduction in ovarian reserve (ERROR): a prospective longitudinal study.

    abstract:OBJECTIVE:To evaluate whether endometrioma is associated with a progressive decline in ovarian reserve, and to compare the rate of decline with natural decline in ovarian reserve. DESIGN:Prospective, observational study. SETTING:Tertiary university hospital, endometriosis clinic. PATIENT(S):Forty women with endometr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kasapoglu I,Ata B,Uyaniklar O,Seyhan A,Orhan A,Yildiz Oguz S,Uncu G

    更新日期:2018-07-01 00:00:00

  • Technology requirements for preimplantation genetic diagnosis to improve assisted reproduction outcomes.

    abstract::Preimplantation genetic diagnosis has been proposed as a method to improve assisted reproduction technology outcomes, but different techniques have produced conflicting results. The use of appropriate techniques may provide positive outcomes. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Munné S,Wells D,Cohen J

    更新日期:2010-07-01 00:00:00

  • Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.

    abstract:OBJECTIVES:To investigate the presence of Poly (ADP-ribose) polymerase (PARP) and evaluate its function in ejaculated spermatozoa. DESIGN:Experimental study. SETTING:Reproductive Research Center. PATIENT(S):Semen specimens from 18 healthy donors and 12 infertile males. INTERVENTION(S):Ejaculated spermatozoa were su...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jha R,Agarwal A,Mahfouz R,Paasch U,Grunewald S,Sabanegh E,Yadav SP,Sharma R

    更新日期:2009-03-01 00:00:00

  • Stromal cells from endometriotic lesions and endometrium from women with endometriosis have reduced decidualization capacity.

    abstract:OBJECTIVE:To evaluate the phenotype, proliferative, and differentiation capacities in vitro of stromal cells derived from peritoneal, ovarian, and deeply infiltrating endometriosis. DESIGN:Experimental study using phase contrast microscopy, immunocytochemistry, and functional bioassays. SETTING:University-based labor...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Klemmt PA,Carver JG,Kennedy SH,Koninckx PR,Mardon HJ

    更新日期:2006-03-01 00:00:00

  • Gamete intrafallopian tube transfer (GIFT): making laparoscopy more than "diagnostic".

    abstract::Diagnostic laparoscopy is commonly performed on patients as part of a complete infertility investigation. Recently published protocols have investigated the efficacy of using empiric ovulation induction, intrauterine insemination, or both before beginning in vitro fertilization. Because many patients enrolled in these...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barad DH,Bartfai G,Barg P,Cohen BL,Feinman M

    更新日期:1988-12-01 00:00:00

  • The effect of Norplant on glucose metabolism under hyperglycemic hyperinsulinemic conditions.

    abstract:OBJECTIVES:To assess the impact of a levonorgestrel-releasing implant contraceptive (Norplant; Wyeth-Ayerst Laboratories, Philadelphia, PA) on glucose metabolism. DESIGN:Prospective evaluation of insulin action and secretion in women under hyperglycemic hyperinsulinemic clamp conditions in the midfollicular phase befo...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Shamma FN,Rossi G,HajHassan L,Penzias AS,Connoly-Diamond M,Jones E,Diamond MP

    更新日期:1995-04-01 00:00:00

  • New Belgian legislation regarding the limitation of transferable embryos in in vitro fertilization cycles does not significantly influence the pregnancy rate but reduces the multiple pregnancy rate in a threefold way in the Leuven University Fertility Cen

    abstract::After the introduction of new Belgian legislation limiting the number of transferable embryos to prevent multiple pregnancies after assisted reproductive technology, the implantation rate per embryo remained stable at 26% and the clinical pregnancy rate per embryo transfer did not change significantly (37.5% before an...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Debrock S,Spiessens C,Meuleman C,Segal L,De Loecker P,Meeuwis L,D'Hooghe TM

    更新日期:2005-05-01 00:00:00

  • Laryngeal cytological aspects in women with surgically induced menopause who were treated with transdermal estrogen replacement therapy.

    abstract:OBJECTIVE:To investigate the effects of estrogen replacement therapy (ERT) on laryngeal cytology in postmenopausal women. DESIGN:Prospective open clinical trial. SETTING:Outpatient menopausal clinic in the Department of Gynecology, University of Catania, Catania, Italy. PATIENT(S):Eighty-four healthy, surgically pos...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Caruso S,Roccasalva L,Sapienza G,Zappalá M,Nuciforo G,Biondi S

    更新日期:2000-12-01 00:00:00

  • First trimester screening for Down's syndrome after assisted reproductive technology: non-male factor infertility is associated with elevated free beta-human chorionic gonadotropin levels at 10-14 weeks of gestation.

    abstract::We retrospectively compared the first trimester Down's syndrome serum screening markers free beta-hCG (fbetahCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks of gestation in 4,088 women with naturally conceived pregnancies and in women pregnant after ICSI (n = 163), IVF (n = 59) and frozen-thawed ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Anckaert E,Schiettecatte J,Sleurs E,Devroey P,Smitz J

    更新日期:2008-10-01 00:00:00

  • Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity.

    abstract:OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Utsuno H,Oka K,Yamamoto A,Shiozawa T

    更新日期:2013-05-01 00:00:00

  • Effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent mouse embryo development.

    abstract:OBJECTIVE:To investigate the effect of a phosphodiesterase type 3 inhibitor in oocyte maturation medium on subsequent embryo development. DESIGN:Animal study. SETTING:University laboratory. ANIMAL(S):CD-1 mice. INTERVENTION(S):Immature oocytes were arrested meiotically in medium containing a specific phosphodiester...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jee BC,Chen HY,Chian RC

    更新日期:2009-05-01 00:00:00

  • Recruiting egg donors online: an analysis of in vitro fertilization clinic and agency websites' adherence to American Society for Reproductive Medicine guidelines.

    abstract:OBJECTIVE:To examine compliance with ethical guidelines of the American Society for Reproductive Medicine (ASRM) regarding trait-based payment variation, presentation of risks, and minimum recruitment age. DESIGN:In June 2010, we systematically examined 207 websites, of which 102 were egg donor agency or IVF clinic we...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Keehn J,Holwell E,Abdul-Karim R,Chin LJ,Leu CS,Sauer MV,Klitzman R

    更新日期:2012-10-01 00:00:00

  • Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary syndrome.

    abstract:OBJECTIVE:To evaluate the effect of growth differentiation factor-9 (GDF-9) and bone morphogenetic protein-15 (BMP-15) on the development of follicles among patients with polycystic ovary syndrome (PCOS). DESIGN:Case-control study. SETTING:University Hospital. PATIENT(S):Twenty-two oocytes were obtained from 15 pati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhao SY,Qiao J,Chen YJ,Liu P,Li J,Yan J

    更新日期:2010-06-01 00:00:00

  • Gonadotropin requirements of the developing follicle.

    abstract:OBJECTIVE:To evaluate follicular FSH and LH requirements during suppression of endogenous gonadotropins with the GnRH antagonist Nal-Glu and whether LH-like activity could be supplied by administering subcutaneous hCG. DESIGN:Randomized clinical trial. PARTICIPANTS:Thirty-two normally cycling females in the late foll...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thompson KA,LaPolt PS,River J,Henderson G,Dahl KD,Meldrum DR

    更新日期:1995-02-01 00:00:00

  • Female obesity increases the risk of miscarriage of euploid embryos.

    abstract:OBJECTIVE:To determine whether female body mass index (BMI) is associated with an increased risk of miscarriage after euploid embryo transfer. DESIGN:A retrospective, observational, multicenter cohort study. SETTING:University-affiliated in vitro fertilization center. PATIENT(S):In this study, 3,480 cycles of in vit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cozzolino M,García-Velasco JA,Meseguer M,Pellicer A,Bellver J

    更新日期:2020-11-30 00:00:00

  • Older first-time mothers and early postpartum depression: a prospective cohort study of women conceiving spontaneously or with assisted reproductive technologies.

    abstract:OBJECTIVE:To evaluate whether older first-time mothers (≥37 years) have higher rates of postpartum depression compared with younger first-time mothers, controlling for mode of conception and known risk factors for postpartum depression. DESIGN:Prospective cohort study. SETTING:Assisted reproductive technology (ART) c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究


    authors: McMahon CA,Boivin J,Gibson FL,Fisher JR,Hammarberg K,Wynter K,Saunders DM

    更新日期:2011-11-01 00:00:00

  • Mechanisms regulating invasiveness and growth of endometriosis lesions in rat experimental model and in humans.

    abstract:OBJECTIVE:To compare the expression of MMP-2, TIMP-2, and TGFbeta2 mRNA in experimental and human endometriotic lesions and to assess the possibility of its cytokine regulation. DESIGN:Experimental laboratory study. SETTING:Medical center. ANIMALS AND PATIENT(S): Thirty female Wistar rats, 17 women with endometriosis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sotnikova NY,Antsiferova YS,Posiseeva LV,Shishkov DN,Posiseev DV,Filippova ES

    更新日期:2010-05-15 00:00:00

  • Influencing factors of adhesion development and the efficacy of adhesion-preventing agents in patients undergoing laparoscopic myomectomy as evaluated by a second-look laparoscopy.

    abstract:OBJECTIVE:To examine the factors influencing the development of adhesions after laparoscopic myomectomy (LM) and the efficacy of adhesion-preventing agents. DESIGN:Prospective nonrandomized study. SETTING:University-affiliated hospital. PATIENT(S):Three hundred seventy-two patients who underwent LM alone by the same...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Takeuchi H,Kitade M,Kikuchi I,Shimanuki H,Kumakiri J,Takeda S

    更新日期:2008-05-01 00:00:00

  • Role of temperature in regulation of spermatogenesis and the use of heating as a method for contraception.

    abstract::A large body of research confirms the vulnerable nature of spermatogenesis to relatively small increases in testicular temperature. Other physical properties of electromagnetic and ultrasound waves have additive or synergistic effects to those of heat and allow disruption of spermatogenic processes at minimal tempera...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Kandeel FR,Swerdloff RS

    更新日期:1988-01-01 00:00:00

  • The role of tubal reconstructive surgery in the era of assisted reproductive technologies.

    abstract::Tubal reconstructive surgery has fewer indications in the era of assisted reproductive technologies than in the past, but is still appropriate and effective treatment for properly selected individuals. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Practice Committee of American Society for Reproductive Medicine.

    更新日期:2008-11-01 00:00:00

  • Peritoneal fluid and serum steroids in infertility patients.

    abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lesorgen PR,Wu CH,Green PJ,Gocial B,Lerner LJ

    更新日期:1984-08-01 00:00:00

  • Intrauterine insemination-ready versus conventional semen cryopreservation for donor insemination: a comparison of retrospective results and a prospective, randomized trial.

    abstract:OBJECTIVE:To compare fecundity rates following intrauterine insemination (IUI) with donor sperm frozen conventionally versus an IUI-ready preparation. DESIGN:Both retrospective results and a prospective, randomized study where recipients were assigned to one of two sperm cryopreservation methods in each cycle of intra...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf DP,Patton PE,Burry KA,Kaplan PF

    更新日期:2001-07-01 00:00:00

  • Inherited thrombophilia in infertile women: implication in unexplained infertility.

    abstract::Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Casadei L,Puca F,Privitera L,Zamaro V,Emidi E

    更新日期:2010-07-01 00:00:00

  • Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.

    abstract:OBJECTIVE:To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS). DESIGN:Prospective study. SETTING:University medical center. PATIENT(S):Thirty-five patients with PCOS and 31 healthy controls. INTERVENTION(S):Peri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pamuk BO,Torun AN,Kulaksizoglu M,Ertugrul D,Ciftci O,Kulaksizoglu S,Yildirim E,Demirag NG

    更新日期:2010-03-01 00:00:00

  • The basal body temperature chart in artificial insemination by donor pregnancy cycles.

    abstract::The basal body temperature (BBT) charts in pregnancy cycles of 110 consecutive women who became pregnant by a single heterologous insemination were studied. The occurrence of ovulation was proved by the pregnancies in each case. All of these pregnancy charts showed a biphasic pattern, and most followed one of three st...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Newill RG,Katz M

    更新日期:1982-10-01 00:00:00

  • Genetic evaluation of oocyte donors: recipient couple preferences and outcome of testing.

    abstract:OBJECTIVE:To report preferences of recipient couples for genetic testing of their oocyte donors. DESIGN:Observational report of results from a genetic testing-options form implemented as part of routine care. SETTING:Private practice. PATIENT(S):Recipients and oocyte donors. INTERVENTION(S):Recipient couples comple...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Baker VL,Rone HM,Adamson GD

    更新日期:2008-12-01 00:00:00

  • Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes.

    abstract:OBJECTIVE:To determine if increases in core body temperature preceding most hot flashes are caused by increased metabolic rate, peripheral vasoconstriction, or central noradrenergic activation. DESIGN:Laboratory physiological study. SETTING:University medical center. PATIENT(S):Fourteen healthy, postmenopausal women...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Freedman RR

    更新日期:1998-08-01 00:00:00

  • Isolation of a factor from normal human semen that accelerates dissolution of abnormally liquefying semen.

    abstract::A liquefraction factor from normal human seminal plasma was purified by cation and anion exchange chromatography. It is nondialyzable, heat-labile, and has many properties in common with the seminal protease "chymotrypsin-like enzyme." Its lytic effect is most distinctly observed in abnormal semen that is semisolid or...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Syner FN,Moghissi KS,Yanez J

    更新日期:1975-11-01 00:00:00

  • Introduction: IVF's 40th world birthday.

    abstract::Forty years ago this month the first baby was born as a result of in vitro fertilization (IVF). The arrival of Louise Brown brought with her a new hope and possibility for the many men and women across the global struggling with infertility who previously had very few options for treatment or family building. In this ...

    journal_title:Fertility and sterility

    pub_type: 历史文章


    authors: Niederberger C,Pellicer A

    更新日期:2018-07-01 00:00:00