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Direct effects of medroxyprogesterone acetate, danazol, and leuprolide acetate on endometrial stromal cell proliferation in vitro.

Abstract：

OBJECTIVE:To assess the direct effects of three endometriosis chemotherapeutic agents (medroxyprogesterone acetate [MPA], danazol, and leuprolide acetate [LA]) on endometrial cell proliferation. DESIGN:Analysis of cell proliferation in vitro. SETTING:Proliferative phase endometrial stromal cells isolated from biopsy specimens and grown in short-term culture served as a model for stromal components of endometriotic implants. PATIENTS:Biopsies obtained from volunteers with regular cycles and without endometriosis or endometrial pathology. INTERVENTIONS:Medroxyprogesterone acetate, danazol, and LA were added to nutrient media with the following supplements: 2.5% calf serum (CS) only; 2.5% CS+estradiol (E2) 110 pmol/L; 2.5% CS+E2 550 pmol/L; 10% preovulatory serum (net E2 624 pmol/L). MAIN OUTCOME MEASURES:Cumulative [3H]-thymidine incorporation as a reflection of cell proliferation. RESULTS:Medroxyprogesterone acetate and danazol exerted significant antiproliferative effects on stromal cell proliferation (P less than 0.05), effects that were enhanced by an absence of exogenous E2. Leuprolide acetate exerted no consistent effects. CONCLUSIONS:These data imply that MPA and danazol but not LA exert direct effects, suppressing growth of endometriotic implants.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Surrey ES,Halme J

keywords:

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

273-8

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)55199-1

journal_volume

58

pub_type

杂志文章

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