Impairment of spermatogenesis and libido through antibodies to lutenizing hormone.

Abstract:

:To histologically and biologically assess the impairment of testicular function after active immunization with LH, adult male rats (49) and rabbits (9) were actively immunized with bovine LH and then compared with saline-injected controls. When the measured antibody titer was high, the mating behavior of the males was altered. The males mated only 41.8% of the time when exposed to cycling females. The control group mated 90% of the time. Testicular weights were unchanged but the seminiferous tubules of the experimental group showed vacuolation in the Sertoli cells with some of the spermatids being multinucleated. Passive immunization of rats with anti-LH sera diminished mating capacity to a greater extent than active immunization. Immunization of rabbits led to a rapid decrease in libido. Uniform interruption of spermatogenesis was noted along with a loss of testicular weight of immunized rabbits. The probable mechanism of the LH inhibition of spermatogenesis is the interference with androgen production in the interstitial tissue.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Talaat M,Laurence KA

doi

10.1016/s0015-0282(16)38046-3

subject

Has Abstract

pub_date

1971-02-01 00:00:00

pages

113-8

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)38046-3

journal_volume

22

pub_type

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