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The effect of 6 weeks of testosterone treatment on pulsatile luteinizing hormone secretion in eugonadal female-to-male transsexuals.

Abstract：

:Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoate, 120 to 160 mg/d orally, on the parameters of the pulsatile secretion of LH in a group of six eugonadal female-to-male transsexuals with normal menstrual cycles. The treatment suppressed menstrual activity in all patients. Serum T and estrone were significantly elevated after treatment with oral T undecanoate. The parameters of the pulsatile secretion of LH were not affected by androgen administration. Levels of FSH, estradiol, and progesterone also did not change significantly.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Scheele F,Hompes PG,Gooren LJ,Spijkstra JJ,Spinder T

doi

10.1016/s0015-0282(16)54194-6

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

608-11

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54194-6

journal_volume

55

pub_type

杂志文章

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