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The cofactor effect: varicocele and infertility.

Abstract：

:The varicocele may be a cofactor that, when potentiated by other cofactors (i.e., gonadotoxins), causes male infertility. This hypothesis could explain the unpredictable effects of the varicocele on fertility. Male rats with experimental varicoceles, sham surgery, or no surgery were treated for 30 days with the known gonadotoxins cyclophosphamide or nicotine. Spermatogenesis was assessed by flow cytometry. Cyclophosphamide alone caused gonadotoxicity, and its effect was accentuated by sham or varicocele surgery. Nicotine and the presence of a varicocele were more gonadotoxic than either the varicocele or nicotine by itself. This data would lend support to the cofactor hypothesis of the pathophysiology of the varicocele.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Peng BC,Tomashefsky P,Nagler HM

subject

Has Abstract

pub_date

1990-07-01 00:00:00

pages

143-8

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)53651-6

journal_volume

54

pub_type

杂志文章

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