Isopropanolic Cimicifuga racemosa is favorable on bone markers but neutral on an osteoblastic cell line.

Abstract:

:Postmenopausal women treated with an isopropanolic extract of Cimicifuga racemosa underwent a decrease in the urinary concentration of N-telopeptides, a marker of bone resorption, and an increase in alkaline phosphatase, a marker of bone formation, at the third month of therapy. Serum from treated women did not modify the activity of alkaline phosphatase or the expression of three genes, runt-related transcription factor-2 (Runx-2), alkaline phosphatase, and osteocalcin, when added to the MC3T3-E1 osteoblastic cell line.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

García-Pérez MA,Pineda B,Hermenegildo C,Tarín JJ,Cano A

doi

10.1016/j.fertnstert.2008.03.042

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

1347-50

issue

4 Suppl

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)00709-7

journal_volume

91

pub_type

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