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Adequate ovarian follicular status does not prevent the decrease in pregnancy rates associated with high sperm DNA fragmentation.

Abstract：

OBJECTIVE:Potential reparation of sperm DNA fragmentation in the oocyte may disturb any relationship between DNA-damaged sperm and the implantation ability of resulting embryos. To rule out this factor, we analyzed the consequences of sperm DNA fragmentation on IVF-ET outcome in women with healthy ovarian function. DESIGN:Prospective study. SETTING:Teaching hospital, France. PATIENT(S):All 117 women were <38 years old, who combined normal serum day-3 FSH and inhibin B levels with an adequate response to controlled ovarian hyperstimulation. INTERVENTION(S):The DNA fragmentation rate was determined in the raw sperm used for conventional IVF by flow cytometric terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay. Cycles were sorted into two groups according to whether DNA fragmentation exceeded (high fragmentation [HF], n = 52) or did not exceed (low fragmentation [LF], n = 65) the 50th percentile of values (35%). MAIN OUTCOME MEASURE(S):D2 embryo quality and implantation and ongoing pregnancy rates. RESULT(S):Patients' characteristics, raw semen parameters, fertilization rates, and embryology data were similar in HF and LF groups. Clinical (37.5% vs. 62.5%) and ongoing (23.5% vs. 57.8%) pregnancy rates per ET and implantation rates (24.5% vs. 42.4%) were lower in the HF group than in the LF group. CONCLUSION(S):High sperm DNA fragmentation spares fertilization and top embryo morphology rates but is associated with decreased IVF-ET outcome.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Frydman N,Prisant N,Hesters L,Frydman R,Tachdjian G,Cohen-Bacrie P,Fanchin R

doi

10.1016/j.fertnstert.2007.02.022

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

92-7

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00414-1

journal_volume

89

pub_type

临床试验,杂志文章

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