Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients.

Abstract:

:Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiology of the disease.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Wang L,Wang Y,Zhang X,Shi J,Wang M,Wei Z,Zhao A,Li B,Zhao X,Xing Q,He L

doi

10.1016/j.fertnstert.2010.01.059

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2486-9, 2489.e1-2

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)00134-2

journal_volume

94

pub_type

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