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Menstrual endometrial cells from women with endometriosis demonstrate increased adherence to peritoneal cells and increased expression of CD44 splice variants.

Abstract：

OBJECTIVE:We previously demonstrated that adherence of endometrial epithelial (EECs) and stromal cells (ESCs) to peritoneal mesothelial cells (PMCs) is partly regulated by ESC/EEC CD44 interactions with PMC associated hyaluronan. CD44, a transmembrane glycoprotein and major ligand for hyaluronan, has numerous splice variants which may impact hyaluronan binding. Here, we assessed whether ESCs and EECs from women with endometriosis demonstrate increased adherence to PMCs and examined CD44 splice variants' potential role in this process. DESIGN:In vitro study. SETTING:Academic medical center. PATIENT(S):Fertility patients with and without endometriosis. INTERVENTION(S):Menstrual endometrium was collected from women with and without endometriosis confirmed surgically. The adherence of ESC/EECs to PMCs was measured. The ESC/EEC CD44 splice variants were assessed using dot-blot analysis. RESULT(S):The ESCs and EECs from women with endometriosis demonstrated increased adherence to PMCs. The predominant CD44 splice variants expressed by ESCs and EECs from women with and without endometriosis were v3, v6, v7, v8, v9, and v10. The ESCs and EECs from women with endometriosis were more likely to express v6, v7, v8, and v9. CONCLUSION(S):Increased eutopic endometrial-PMC adherence and CD44 splice variant expression may contribute to the histogenesis of endometriotic lesions. Elucidation of factors controlling this expression may lead to novel endometriosis therapies.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Griffith JS,Liu YG,Tekmal RR,Binkley PA,Holden AE,Schenken RS

doi

10.1016/j.fertnstert.2008.12.012

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1745-9

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(08)04702-X

journal_volume

93

pub_type

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