Menses resumption after cancer treatment-induced amenorrhea occurs early or not at all.


OBJECTIVE:To identify factors associated with cancer treatment-induced amenorrhea and time to return of menses. DESIGN:Population-based cohort study. SETTING:Not applicable. PATIENT(S):Female cancer survivors who were diagnosed with cancer between the ages of 20 and 35 and were at least 2 years postdiagnosis at the time of recruitment (median = 7 years; interquartile range, 5-11). INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Amenorrhea (≥6 months without menses) and resumption of menses. RESULT(S):After excluding women with hysterectomies before cancer diagnosis, 1,043 women were eligible for analysis. Amenorrhea occurred in 31.6% of women. Among women treated with chemotherapy (n = 596), older age at diagnosis (30-35 vs. 20-24 years: adjusted odds ratio [aOR] = 2.37; 95% confidence interval [CI], 1.30, 4.30) and nulligravidity (vs. gravid: aOR = 1.50; 95% CI, 1.02, 2.21) were risk factors for amenorrhea. Among amenorrheic women, menses resumed in most (70.0%), and resumption occurred within 2 years of treatment for 90.0% of women. Survivors of breast cancer were more likely to resume menses at times greater than 1 year compared with lymphoma and pelvic-area cancers. Women diagnosed at older ages, those exposed to chemotherapy, and those exposed to any radiation experienced longer times to return of menses. Women who were older at diagnosis were more likely to have irregular cycles when menses returned. CONCLUSION(S):Treatment-induced amenorrhea is common in cancer survivors, although most women resume menses within 2 years. However, once resumed, older women are more likely to have irregular cycles. Age at diagnosis and pregnancy history affect the risk of amenorrhea.


Fertil Steril


Fertility and sterility


Jacobson MH,Mertens AC,Spencer JB,Manatunga AK,Howards PP




Has Abstract


2016-03-01 00:00:00














  • Effect of short-term hormone replacement therapy on left ventricular mass and contractile function.

    abstract:OBJECTIVE:To determine the effect of hormone replacement therapy (HRT) on cardiac structure and function and whether these changes are related to changes in blood volume. DESIGN:Open-label pilot study. SETTING:Academic medical center. PATIENT(S):Eighteen healthy postmenopausal women. INTERVENTION(S):We administered...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Sites CK,Tischler MD,Blackman JA,Niggel J,Fairbank JT,O'Connell M,Ashikaga T

    更新日期:1999-01-01 00:00:00

  • Presence of soluble b-type cytochrome in human seminal fluid.

    abstract::In 1951 it was shown that human spermatozoa contained cytochromes a, b, and c. It was noted that the cytochromes were confined to the sperm and were not found in seminal fluid. More recently we have observed in seminal plasma a soluble component that has a typical spectrum of a reduced cytochrome b, but can be disting...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Trifunac NP,Bernstein GS

    更新日期:1981-03-01 00:00:00

  • Rigorous thermal control during intracytoplasmic sperm injection stabilizes the meiotic spindle and improves fertilization and pregnancy rates.

    abstract:OBJECTIVE:To examine the effects of different thermodynamic control systems on the temperature stability of human eggs during in vitro manipulation, with the integrity of meiotic spindles imaged using the LC-PolScope (Cambridge Research & Instrumentation, Inc., Woburn, MA). DESIGN:We performed intracytoplasmic sperm i...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang WH,Meng L,Hackett RJ,Oldenbourg R,Keefe DL

    更新日期:2002-06-01 00:00:00

  • Elevated serum estradiol associated with increased androstenedione-testosterone ratio in adolescent males with varicocele and gynecomastia.

    abstract:OBJECTIVE:To investigate the testicular function in adolescents with pubertal gynecomastia associated with varicocele before and after varicocelectomy. DESIGN AND PATIENTS:We have studied six male adolescents 15 to 19 years of age with bilateral gynecomastia. They were selected among other adolescents with gynecomasti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Castro-Magana M,Angulo M,Uy J

    更新日期:1991-09-01 00:00:00

  • Neural tube defects after infertility treatment: a review.

    abstract:OBJECTIVE:To investigate whether an association exists between ovulation induction and neural tube defects (NTDs). MATERIALS AND METHODS:Risk estimations in the medical literature were identified through Medline, and validity and power were assessed. Large in vitro fertilization-embryo transfer (IVF-ET) registries rep...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Van Loon K,Besseghir K,Eshkol A

    更新日期:1992-11-01 00:00:00

  • Migraine in women with chronic pelvic pain with and without endometriosis.

    abstract:OBJECTIVE:To examine the prevalence of migraine in women with chronic pelvic pain with and without endometriosis. DESIGN:Prospective study of headache, pelvic pain, and quality of life before laparoscopic surgery for pelvic pain. Endometriosis was diagnosed pathologically. Headaches were classified as migraine or non-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Karp BI,Sinaii N,Nieman LK,Silberstein SD,Stratton P

    更新日期:2011-03-01 00:00:00

  • A steroid cell tumor outside the ovary is a rare cause of virilization.

    abstract:OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Smith D,Crotty TB,Murphy JF,Crofton ME,Franks S,McKenna TJ

    更新日期:2006-01-01 00:00:00

  • Chromosomal abnormalities in embryos derived from testicular sperm extraction.

    abstract:OBJECTIVE:To compare the rate of chromosome abnormalities in embryos obtained from karyotypically normal patients with nonobstructive azoospermia undergoing testicular sperm extraction (TESE) to those from patients undergoing intracytoplasmic sperm injection (ICSI) with ejaculated sperm. DESIGN:Retrospective analysis....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Silber S,Escudero T,Lenahan K,Abdelhadi I,Kilani Z,Munné S

    更新日期:2003-01-01 00:00:00

  • Elective single blastocyst transfer.

    abstract::This report describes our initial experience with elective single blastocyst transfer in 19 patients who had a mean age of 36.3 +/- 2.4 years. The ongoing pregnancy rate, 53% after the fresh embryo transfer and 68% when thaw cycles are included, suggests that single blastocyst transfer has a place in this relatively o...

    journal_title:Fertility and sterility

    pub_type: 信件


    authors: Milki AA,Hinckley MD,Westphal LM,Behr B

    更新日期:2004-06-01 00:00:00

  • Echographic study of follicular maturation and ovulation during the normal menstrual cycle.

    abstract::Follicular development was followed by echography during 18 menstrual cycles in 10 women volunteers. Results were correlated with changes in serum hormone levels, basal body temperature curves, and cervical mucus changes. The average follicular growth as measured from the time of echographic visualization was 0.3 cm/d...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Renaud RL,Macler J,Dervain I,Ehret MC,Aron C,Plas-Roser S,Spira A,Pollack H

    更新日期:1980-03-01 00:00:00

  • Deoxyribonucleic acid flow cytometry of germ cells in the investigatin of male infertility.

    abstract::DNA flow cytometry was applied to fine-needle aspiration biopsy specimens from the testes of 20 oligospermic or azoospermic men under investigation for infertility. All aspirations gave sufficient material for DNA flow cytometry, and no complications occurred after aspiration. In both groups many DNA patterns deviated...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Clausen OP,Abyholm T

    更新日期:1980-10-01 00:00:00

  • An analysis of endometrial biopsies performed for infertility.

    abstract::The authors evaluated 774 endometrial biopsies that were performed for infertility. Complications arose in 3.6%. Lag of more than 2 days was found in 19%; luteal phase defect (LPD) was diagnosed in 5.7%. Most of the incidence of LPD can be predicted from chance occurrence. There was no association between abnormal bio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Davidson BJ,Thrasher TV,Seraj IM

    更新日期:1987-11-01 00:00:00

  • Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome.

    abstract:OBJECTIVE:To determine expression of integrins α₁, α₄, and αVβ₃ in the glandular and luminal epithelium, stroma, and cells in the blood vessel walls of the endometrium from women with recurrent implantation failure (RIF) and to determine if they are of prognostic value in determining pregnancy outcome. DESIGN:Prospect...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Coughlan C,Sinagra M,Ledger W,Li TC,Laird S

    更新日期:2013-09-01 00:00:00

  • Impact of a cryopreservation program on the multiple pregnancy rate associated with assisted reproductive technologies.

    abstract:OBJECTIVE:To determine the impact of a cryopreservation program on pregnancy rates and multiple-pregnancy rates in ART cycles. DESIGN:Retrospective study. SETTING:University teaching hospital. PATIENT(S):Women who underwent stimulation for in vitro fertilization at the Jones Institute for Reproductive Medicine betwe...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Schnorr JA,Doviak MJ,Muasher SJ,Jones HW Jr

    更新日期:2001-01-01 00:00:00

  • Inhibin-B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening.

    abstract:OBJECTIVE:To determine inhibin-B concentrations during ovarian reserve screening in women with normal and diminished ovarian reserve as determined by the clomiphene citrate challenge test. DESIGN:Retrospective. SETTING:Tertiary fertility center. PATIENT(S):Women undergoing ovarian reserve screening for a routine fer...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hofmann GE,Danforth DR,Seifer DB

    更新日期:1998-03-01 00:00:00

  • Serum vascular endothelial growth factor concentrations in in vitro fertilization cycles predict the risk of ovarian hyperstimulation syndrome.

    abstract:OBJECTIVE:To explore the value of serum vascular endothelial growth factor (VEGF) concentrations during IVF cycles in predicting the risk of ovarian hyperstimulation syndrome (OHSS). DESIGN:Prospective study. SETTING:London Women's Clinic. PATIENT(S):One hundred seven women undergoing IVF. Mild OHSS developed in 10 ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Agrawal R,Tan SL,Wild S,Sladkevicius P,Engmann L,Payne N,Bekir J,Campbell S,Conway G,Jacobs H

    更新日期:1999-02-01 00:00:00

  • The relation of fertility and ovarian histology after bilateral ovarian wedge resection.

    abstract::The immediate and long term fertility after bilateral ovarian wedge resection in 53 women with clomiphene citrate-resistant hyperandrogenic chronic anovulation is related to the histology of the ovarian wedges. Patients with polycystic ovaries and hyperplastic stromal abnormalities had most spontaneous conceptions and...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lappöhn RE,Bogchelman DH

    更新日期:1989-08-01 00:00:00

  • Effect of ovariectomy on the gene expression of detrusor muscarinic receptors in female rats.

    abstract::Eight rats served as control subjects with sham surgeries and eight rats underwent ovariectomy. Two months later, the expression of muscarinic receptors, neuronal nitric oxide synthase (nNOS), and estrogen receptor (R) at the mRNA level were assessed by reverse-transcription polymerase chain reaction. The results show...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Long CY,Hsu CS,Shao PL,Liu CM,Su JH,Tsai EM

    更新日期:2009-09-01 00:00:00

  • Alternation of cytosolic carbonic anhydrase isoenzymes during deciduomatal development in pregnant mice.

    abstract:OBJECTIVE:To analyze the activity of cytosolic carbonic anhydrases (CAs) during the pre- and postimplantation stages of pregnancy in mice. Furthermore, to investigate the CA activity in mice in which abortion was induced by injection of substance P. DESIGN:Controlled animal experiment. SETTING:University research lab...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chiang WL,Liu JY,Liao CY,Yang SF,Hsieh YS,Chu SC

    更新日期:2004-10-01 00:00:00

  • Transcervical placement of a Malecot catheter after hysteroscopic evaluation provides for easier entry into the endometrial cavity for women with histories of difficult intrauterine inseminations and/or embryo transfers: a prospective case series.

    abstract:OBJECTIVE:To evaluate a new technique designed to improve access to the endometrial cavity through tortuous and/or stenotic endocervical canals in women with histories of difficult IUIs, ETs, or endometrial biopsies. DESIGN:Prospective case series. SETTING:Tertiary care center. PATIENT(S):Women with histories of dif...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Yanushpolsky EH,Ginsburg ES,Fox JH,Stewart EA

    更新日期:2000-02-01 00:00:00

  • A healthy live birth after successful preimplantation genetic diagnosis for carriers of complex chromosome rearrangements.

    abstract:OBJECTIVE:To report a live birth after successful preimplantation genetic diagnosis (PGD) for carriers of complex chromosomal rearrangements (CCRs) with translocation and deletion. DESIGN:Fluorescent in situ hybridization (FISH) was applied to PGD for CCR carriers. SETTING:University-based centers for reproductive me...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lim CK,Cho JW,Kim JY,Kang IS,Shim SH,Jun JH

    更新日期:2008-11-01 00:00:00

  • Impact of follicular-fluid meiosis-activating sterol in an albumin-based formulation on the incidence of human pre-embryos with chromosome abnormalities.

    abstract:OBJECTIVE:To evaluate the effect of adding follicular-fluid meiosis-activating sterol (FF-MAS) in a novel 0.2% recombinant human albumin-based formulation to cumulus-enclosed oocytes on chromosomal status and development of pre-embryos. DESIGN:Multicenter, prospective, randomized, open (double-blind for vehicle and FF...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Loft A,Ziebe S,Erb K,Rasmussen PE,Agerholm I,Hauge B,Bungum M,Bungum L,Grøndahl C,Lyby K

    更新日期:2005-10-01 00:00:00

  • Flow cytometry provides rapid and highly accurate detection of antisperm antibodies.

    abstract:OBJECTIVE:Immunobead testing (IBT), the current standard for antisperm antibody detection, is time consuming and somewhat subjective. To overcome these limitations and maintain accuracy, we studied an immunofluorescent assay using flow cytometry. DESIGN:A validation study comparing flow cytometry to IBT in the detecti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ke RW,Dockter ME,Majumdar G,Buster JE,Carson SA

    更新日期:1995-04-01 00:00:00

  • Occurrence of a spontaneous luteinizing hormone surge in superovulated cycles--predictive value of serum progesterone.

    abstract::A preovulatory increase in serum progesterone (P) precedes the occurrence of an endogenous luteinizing hormone (LH) surge in a majority of women. This study evaluates whether a single daily measurement of serum P could reliably identify a spontaneous LH surge in women undergoing controlled ovarian hyperstimulation. Ei...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serafini P,Stone B,Kerin J,Batzofin J,Quinn P,Marrs RP

    更新日期:1988-01-01 00:00:00

  • A meta-analysis of ultrasound-guided versus clinical touch embryo transfer.

    abstract:OBJECTIVE:To determine the relative efficacy of ultrasound-guided embryo transfer and embryo transfer by clinical touch alone. DESIGN:Systematic review and meta-analysis of randomized, controlled trials comparing ultrasound-guided embryo transfer with embryo transfer by clinical touch alone. SETTING:Infertility cente...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Buckett WM

    更新日期:2003-10-01 00:00:00

  • Administration of nasal Buserelin as compared with subcutaneous Buserelin implant for endometriosis.

    abstract::One hundred infertile patients with laparoscopically confirmed ovarian endometriosis were treated with either intranasal (IN) Buserelin (Hoechst, AG, Frankfurt am Main, West Germany) (300 micrograms three times a day) or subcutaneous (SC) Buserelin implant (6.6 mg Buserelin). Serum estradiol was suppressed in the meno...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Donnez J,Nisolle-Pochet M,Clerckx-Braun F,Sandow J,Casanas-Roux F

    更新日期:1989-07-01 00:00:00

  • Society for assisted reproductive technology position statement on donor suitability of recipients of smallpox vaccine (vaccinia virus).

    abstract::Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that assisted reproductive technology (ART) practitioners consider deferring donors who have recently received smallpox vaccine or contracted symptomatic vaccinia virus in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee of the American Society for Reproductive Medicine.,Society for Assisted Reproductive Technology.

    更新日期:2004-04-01 00:00:00

  • Histopathological changes in leiomyomata treated with leuprolide acetate.

    abstract::Several studies have shown a decrease in uterine and/or leiomyoma volume when treated with leuprolide acetate (LA), a widely used gonadotropin-releasing hormone agonist. The mechanism by which these changes occur is unknown. In this study, the histopathological slides of 31 women of reproductive age who underwent hyst...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Upadhyaya NB,Doody MC,Googe PB

    更新日期:1990-11-01 00:00:00

  • Recommended practices for the management of embryology, andrology, and endocrinology laboratories: a committee opinion.

    abstract::This document provides a general overview for physicians of the qualities and conditions necessary for good management practices within the endocrinology, andrology, and embryology laboratories in the United States. It is intended as an addendum to previously published guidelines that further detail these responsibili...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引,评审


    authors: Practice Committee of the American Society for Reproductive Medicine.,Practice Committee of the Society for Assisted Reproductive Technology.,Practice Committee of the Society of Reproductive Biologists and Technologists.

    更新日期:2014-10-01 00:00:00

  • High pregnancy rates can be achieved after freezing and thawing human blastocysts.

    abstract:OBJECTIVE:To examine the results of a 3-year trial using blastocyst cryopreservation to limit multiple pregnancy and optimize overall pregnancy per cycle. DESIGN:Retrospective clinical evaluation of pregnancy rates after freezing and thawing human blastocysts. SETTING:Tertiary-care academic center. PATIENT(S):Seven ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Veeck LL,Bodine R,Clarke RN,Berrios R,Libraro J,Moschini RM,Zaninovic N,Rosenwaks Z

    更新日期:2004-11-01 00:00:00