Abstract:
:Rhesus monkeys immunized with the beta-subunit of ovine luteinizing hormone (oLHbeta) developed circulating antibodies which cross-reacted strongly with rhesus monkey chorionic gonadotropin. Normal ovulatory cycles continued, but the fertility of immunized monkeys as compared with that of controls was significantly reduced. Thus, the rhesus monkey represented a useful animal model for the study of certain aspects of an "antifertility vaccine." We investigated the effects of circulating antibodies to oLHbeta on corpus luteum function by measuring production rates (PRs) and peripheral concentrations of progesterone during the luteal phase of the menstrual cycle. Both parameters were significantly lower in immunized animals than in control animals. The length of the menstrual cycle was also significantly reduced. Progesterone PRs were also determined on days 10 and 15 after mating to test the assumption that the antifertility vaccine prevents pregnancy by interfering with "corpus luteum rescue" (the increase in PRs of progesterone usually occurring on day 15 after mating in fertilized animals). PRs increased from days 10 to 15 in pregnant controls, were unchanged in nonpregnant controls, and were significantly lower on day 15 in immunized monkeys as compared with nonpregnant and pregnant controls. These results suggest that "corpus luteum rescue" is suppressed in immunized animals.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Thau RB,Sundaram K,Thornton YS,Seidman LSkeywords:
subject
Has Abstractpub_date
1979-02-01 00:00:00pages
200-4issue
2eissn
0015-0282issn
1556-5653pii
S0015-0282(16)43823-9journal_volume
31pub_type
杂志文章abstract::For sperm DNA assessments to be widespread effective clinical tools, key objectives need to be urgently achieved. These include robust standardized methods, systems for training staff and ongoing quality control; and rigorous examination of the clinical outcomes. We discuss the significance of these objectives and con...
journal_title:Fertility and sterility
pub_type: 社论
doi:10.1016/j.fertnstert.2010.07.1050
更新日期:2010-11-01 00:00:00
abstract::The addition of 4% dl-methionine to a diet of 18% or 12% casein reduced pregnancy maintenance in the rat from 100% to 48% and 5%, respectively. Fetal weight was subnormal. The major influence of methionine was not due to reduced food intake as determined by pair-fed controls but was related to reduced ovarian function...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42563-x
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the expression, regulation, and role of interleukin (IL)-8 in human ovary. DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):Sixteen premenopausal women. INTERVENTION:Follicular fluid and granulosa lutein cells (GLCs) were collected during IVF cycles. Ovarian stromal and theca ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)04408-4
更新日期:2003-01-01 00:00:00
abstract::This document is designed to provide a framework for assisted reproductive technology (ART) programs that meet or exceed the requirements suggested by the Centers for Disease Control and Prevention (CDC) for certification of ART laboratories. This document replaces the document, "Revised Minimum Standards for Practices...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引
doi:10.1016/j.fertnstert.2019.11.024
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To assess the role of the variant p.Asn680Ser in the follicle-stimulating hormone receptor (FSHR) gene in determining ovarian response in patients undergoing in vitro fertilization (IVF) treatment. DESIGN:Prospective observational study. SETTING:Tertiary referral center for reproductive medicine. PATIENT(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.037
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hor...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.11.031
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between MMPI-2 scores and oocyte donation outcome. DESIGN:Descriptive chart review. SETTING:Two oocyte donation programs. SUBJECT(S):Five hundred anonymous oocyte donor applicants. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Demographics, MMPI-2 scores and donation outcome. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.08.064
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55708-2
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata. DESIGN:Screen by arrays for up to 12,000 genes in leiomyoma (L) and control myometrium (M) from nine patients. SETTING:University research laboratories. PATIENT(S):Nine patients...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)03191-6
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To analyze relationships between serum free fatty acid (FFA) concentrations and pregnancy. DESIGN:Prospective cohort. SETTING:University hospital. PATIENT(S):Ninety-one women undergoing IVF. INTERVENTION(S):Serum was analyzed for total and specific serum FFAs, including myristic, palmitic, stearic, oleic,...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.07.1115
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To assess the hypothesis that pregnancy rates (PRs) after operative laparoscopy (Laparoscopy Group) for endometriosis treatment would be equal to or greater than diagnostic laparoscopy only (No Treatment Group), diagnostic laparoscopy with medical treatment (Medical Treatment Group), and laparotomy (Laparotom...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::At present there is no agreement regarding the usefulness of monitoring the endometrial thickness in stimulated cycles. We tested prospectively the hypothesis of a linear relationship of the given individual uterine size and the endometrial thickness in stimulated cycles using a 240 degrees transvaginal sector scanner...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)56716-8
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:To measure the level of distress and its relationship with other psychologic factors in women with diminished ovarian reserve (DOR) who participated in a fragile X genetics study. DESIGN:Longitudinal data analyzed with structural equation modeling. SETTING:Four U.S. private and academic fertility centers. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2013.02.033
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To determine the expression profile of small noncoding RNAs (sncRNAs) in leiomyoma, which has not been investigated to date. DESIGN:Laboratory-based investigation. SETTING:Academic center. PATIENT(S):Women undergoing hysterectomy for benign indications. INTERVENTION(S):Next-generation sequencing and scree...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.01.034
更新日期:2018-05-01 00:00:00
abstract::Of 5,341 infertile couples seen over an 8-year period, 76 (1.4%) had primary vaginismus, of whom 63 were treated with the use of a simplified sensate focus technique. There was complete symptomatic resolution of vaginismus in 60 women, and pregnancy was achieved in 33. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.03.071
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To determine if androstenedione (A) and progesterone (P) concentrations in preovulatory follicular fluid (FF) correlate with successful fertilization and cleavage of human oocytes in vitro. DESIGN:A retrospective randomized trial. SETTING:Hospital department of obstetrics and gynecology. PATIENTS:Fifty-fiv...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(16)54489-6
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of progestogen supplementation in improving clinical pregnancy rates in women undergoing fresh IVF cycles and to compare different routes, start times, durations, and estrogen coadministration regimen. DESIGN:Comprehensive systematic review and meta-analysis. SETTING:University...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/j.fertnstert.2019.04.021
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the role of 3,3',5-triiodothyronine (T(3)) on ovarian follicle development in vitro. DESIGN:Experimental study. SETTING:University reproductive biology unit. ANIMAL(S):CD1 mice (female). INTERVENTION(S):In vitro culture. MAIN OUTCOME MEASURE(S):Assessment of follicle and oocyte development fo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.11.014
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To clarify the role and mechanism of CCL2 in regulating the biological functions of endometrial stromal cells (ESCs). DESIGN:The CCL2 effect on the viability, proliferation, and invasion in the eutopic ESCs from endometriosis. SETTING:Research laboratories. PATIENT(S):Patients with endometriosis aged 23-47...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.12.049
更新日期:2012-04-01 00:00:00
abstract::A new sperm isolation technique was studied in conjunction with the short-term freeze preservation of human spermatozoa. The isolation procedure yielded subpopulations of spermatozoa with very high percentage motility and progressive motility score, and which were virtually free of seminal debris. For 24 semen samples...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42196-5
更新日期:1976-11-01 00:00:00
abstract::Two models of levonorgestrel-releasing intrauterine devices were studied. Model A was designed to deliver 20 micrograms/day, and model B was designed to deliver 30 micrograms/day. Plasma concentrations of levonorgestrel were determined in blood samples taken from women who used the levonorgestrel-releasing intrauterin...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(16)49397-0
更新日期:1986-06-01 00:00:00
abstract:OBJECTIVE:To assess the minimal effective dose of a GnRH antagonist (Cetrorelix; Asta Medical; Frankfurt, Germany) to prevent premature LH surge in patients undergoing controlled ovarian hyperstimulation (COH) for assisted reproductive technologies. DESIGN:In 69 patients COH was carried out with the association of hMG...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81407-0
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)80089-1
更新日期:1997-03-01 00:00:00
abstract::This study investigated the prevalence of Tyr204Phe and Val34Leu polymorphisms in two Brazilian ethnic groups (171 Caucasians and 27 Blacks, and 117 men and 81 women) and in patients with recurrent miscarriages (RM) (86 women: 53 Caucasians and 33 Blacks). Study groups were matched to control groups by race and age. T...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2004.04.052
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To report the case of a female who presented in childhood with symptoms and signs of hyperandrogenism secondary to an extraovarian steroid cell tumor. DESIGN:Case report. SETTING:Endocrine investigation unit of a university teaching hospital. PATIENT(S):An 11-year-old female presented with symptoms and sig...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.06.055
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of preimplantation genetic screening (PGS) on morphologic outcome in children. DESIGN:Follow-up of a randomized controlled trial (RCT). SETTING:University hospital. PATIENT(S):Two-year-old children born to mothers who participated in an RCT on the efficacy of PGS: 50 children born af...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2012.10.024
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To investigate the functional and sexual outcome of sigmoid vaginoplasty in patients with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):Fifty-nine consecutive patients with MRKH syndrome. INTERVENTION(S):Forty-eight patients underwent sig...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.12.015
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To study the effect of mifepristone on heparin-binding epidermal growth factor (HB-EGF) and its receptors HER1 and HER4 in the fallopian tube and in the endometrium. DESIGN:Prospective clinical study. SETTING:Hospital-based unit for obstetrics and gynecology and research laboratories. PATIENT(S):Healthy wo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.011
更新日期:2006-01-01 00:00:00
abstract::We have microsurgically extracted a pronucleus from 11 tripronuclear human zygotes under two different experimental conditions. One group of six zygotes was incubated in cytochalasin D for 30 minutes before manipulation. The remaining five zygotes were manipulated without preincubation in cytoskeletal relaxing agents....
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60901-9
更新日期:1989-09-01 00:00:00
abstract::A group of 216 vasovasostomized men were tested with the mixed antiglobulin reaction for immunoglobulin (Ig)G, IgA, and secretory IgA antisperm antibodies bound to the sperm membrane. Free antisperm antibodies in serum and seminal plasma were detected with the gelatin agglutination test and the tray agglutination test...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00