Abstract:
OBJECTIVE:To evaluate the role of 3,3',5-triiodothyronine (T(3)) on ovarian follicle development in vitro. DESIGN:Experimental study. SETTING:University reproductive biology unit. ANIMAL(S):CD1 mice (female). INTERVENTION(S):In vitro culture. MAIN OUTCOME MEASURE(S):Assessment of follicle and oocyte development following a 6-day culture with FSH (100 mU/mL), (Bu)(2)cAMP (0.5 mM), and T(3) (1-100 nM), alone or in combination. RESULT(S):A high percentage of in vitro grown (IVG) FSH-stimulated follicles formed an antral cavity (AC), while the addition of T(3) (100 nM) significantly reduced this response in a statistically significant manner. A statistically significant recovery of AC formation was obtained by limiting exposure to 4 days of culture. Formation of AC was induced by (Bu)(2)cAMP, which prevented T(3)-mediated suppression of AC formation. Under different conditions, high proportions of germinal vesicle-arrested IVG oocytes displayed condensed chromatin configuration. The capacity to undergo germinal vesicle breakdown (GVBD) was similar in all groups, and a statistically significant reduction in the percentage of oocytes with PB1 was recorded when T(3) was added to FSH or (Bu)(2)cAMP. This ability was partially recovered by removing T(3) on day 4 of culture. CONCLUSION(S):Exposure to high T(3) concentrations can impair preantral follicle development, but this effect can be partly reverted by restoring a physiological hormonal milieu before follicle commitment to antral development.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Cecconi S,Rossi G,Coticchio G,Macchiarelli G,Borini A,Canipari Rdoi
10.1016/j.fertnstert.2003.11.014keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
919-24eissn
0015-0282issn
1556-5653pii
S0015028203030644journal_volume
81 Suppl 1pub_type
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journal_title:Fertility and sterility
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journal_title:Fertility and sterility
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journal_title:Fertility and sterility
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abstract:OBJECTIVE:To investigate the localization of tenascin expression in the endometrium of women without endometriosis and in endometriotic implants, and to determine the in vitro regulation of tenascin by E(2) in these tissues. DESIGN:Experimental laboratory study. SETTING:University medical center. PATIENT(S):Reproduc...
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abstract:OBJECTIVE:To investigate the role(s) of hyaluronan synthase 2 (HAS2) and hyaluronan in disease progression of endometriosis and epidermal growth factor (EGF)-induced motility changes of endometriotic cells. DESIGN:A case-control experimental study and in vitro primary cell culture study. SETTING:University hospital-a...
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journal_title:Fertility and sterility
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journal_title:Fertility and sterility
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journal_title:Fertility and sterility
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journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引
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更新日期:2018-06-01 00:00:00
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journal_title:Fertility and sterility
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更新日期:2015-05-01 00:00:00
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journal_title:Fertility and sterility
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更新日期:2014-01-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.046
更新日期:2006-03-01 00:00:00
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journal_title:Fertility and sterility
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doi:
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更新日期:1997-11-01 00:00:00
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journal_title:Fertility and sterility
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更新日期:1997-06-01 00:00:00
abstract::To evaluate the effect of luteal estrogen supplementation on pregnancy rates in normal responder IVF patients treated with recombinant FSH and fixed multidose GnRH antagonist, patients were randomized into two groups to receive vaginal 600 mg/d micronized progesterone for luteal phase supplementation with or without t...
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...
journal_title:Fertility and sterility
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journal_title:Fertility and sterility
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更新日期:2013-09-01 00:00:00
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journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.04.003
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To develop an experimental model for embryos with a defect specific to hatching, with the purpose of clarifying the mammalian embryo hatching mechanism. DESIGN:A microneedle was inserted under the zona pellucida (ZP) of mouse embryos, and either 1/2 or 1/4 of the blastomeres were mechanically destroyed. The ...
journal_title:Fertility and sterility
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abstract:OBJECTIVE:To introduce an innovation that combines single port laparoscopic and Wharton-Sheares-George cervicovaginal reconstruction using a small intestinal submucosa (SIS) graft in a patient with congenital cervical atresia, absence of vagina, and incomplete uterine septum (U2aC4V4). DESIGN:Video article introducing...
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更新日期:2020-03-01 00:00:00