Abstract:
OBJECTIVE:To assess fertility counseling and preservation practices among children, adolescents, and young adults with rheumatic diseases undergoing cyclophosphamide (CTX) treatment. DESIGN:Retrospective chart review (2006-2016). SETTING:Academic pediatric center. PATIENT(S):Male and female patients with systemic lupus erythematosus, Wegener's granulomatosis/granulomatosis with polyangiitis, or other vaculitides, receiving CTX treatment. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Documentation of fertility counseling and fertility preservation. RESULT(S):A total of 58 subjects met the inclusion criteria; 5 were excluded due to incomplete records, thus N = 53. Of these 75% were female (N = 40). Median age was 14 years at diagnosis and 15 years at first CTX treatment. A total of 51% of subjects (69% of males and 45% of females) had no documentation about potential fertility loss before CTX treatment. Among females where fertility counseling was documented, the only fertility preservation option discussed was leuprolide acetate (LA), which was pursued in all of these cases. Of 13 males (77% postpubertal), 3 were offered sperm banking, of whom 2 declined and the other attempted after treatment began and was azoospermic. Of 53 patients, 1 was referred to a fertility specialist. Mean cumulative CTX dose was 9.2 g in males and 8 g in females. CONCLUSION(S):Based on these findings, increasing awareness about infertility risk, fertility preservation options, and referral to fertility specialists is needed among pediatric rheumatologists. Prospective studies are needed to assess fertility outcomes in this patient population (including effectiveness of LA with regard to pregnancy rates [PRs]), as well as barriers/facilitators to fertility counseling and fertility preservation.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Nahata L,Sivaraman V,Quinn GPdoi
10.1016/j.fertnstert.2016.07.1102subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1470-1474issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(16)62539-6journal_volume
106pub_type
杂志文章abstract:OBJECTIVE:To evaluate the consistency and objectivity of deep neural networks in embryo scoring and making disposition decisions for biopsy and cryopreservation in comparison to grading by highly trained embryologists. DESIGN:Prospective double-blind study using retrospective data. SETTING:U.S.-based large academic f...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.12.004
更新日期:2020-04-01 00:00:00
abstract::Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2019.10.004
更新日期:2019-11-01 00:00:00
abstract::In a program of human in vitro fertilization (IVF), the results of 204 attempted intracervical embryo transfers (ETs), using a variety of catheters in three trials over 18 months, have been analyzed for the ease of transfer and pregnancy rate. In nulliparous patients, transfers were more difficult than in multiparous ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46451-4
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:To review the available information regarding the polypeptide factors inhibin, activin, and follistatin in reproductive physiology. DESIGN:The protein structure, tissue expression, regulation, and effects of these factors are outlined, with an emphasis on the reproductive tissues in both females and males. A...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/s0015-0282(16)58137-0
更新日期:1996-03-01 00:00:00
abstract::Direct effects of a gonadotropin-releasing hormone agonist (GnRHa), danazol, or estrogen/progestogen (E/P) on experimental endometriosis were evaluated in castrated female rats. Endometrial explants decreased in size following castration, but there was no further change in the treatment groups. Histologic examination ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59727-1
更新日期:1988-02-01 00:00:00
abstract:OBJECTIVE:To determine whether concurrent use of GnRH agonists with chemotherapy preserves ovarian function in women with breast cancer who did not use tamoxifen. DESIGN:Systematic review and meta-analysis. SETTING:University-based hospitals. PATIENT(S):Premenopausal women with breast cancer treated with chemotherap...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2014.06.003
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To study the correlation between indices of air pollution and sperm parameters. DESIGN:Ecological study. SETTING:Contained geographic area. PATIENT(S):Resident men presenting for semen analysis or artificial insemination. INTERVENTION(S):Analysis of levels of particulate air pollution (particulate matter ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.089
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To investigate whether ghrelin signaling is involved in the pathogenesis of male factor infertility induced by leptin deficiency. DESIGN:Experimental study. SETTING:University academic medical center. ANIMAL(S):Ten-week-old C57BL/6J mice and ob/ob mice. INTERVENTION(S):Western blotting, (quantitative) rev...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.11.022
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To explore the long-term outcome of patients who began IVF treatment by considering not only treatment outcome in the center but also the parenthood project outcome after discontinuation of unsuccessful IVF. DESIGN:Retrospective cohort follow-up study. SETTING:Two French IVF centers. PATIENT(S):Seven hundr...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.05.067
更新日期:2009-07-01 00:00:00
abstract::After four unsuccessful attempts at multiple follicular induction with exogenous gonadotropins, a patient underwent two attempts at IVF in spontaneous cycles triggered with hCG. The second attempt resulted in the transfer of three embryos and a successful singleton intrauterine pregnancy. We believe that unstimulated ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60746-x
更新日期:1989-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of methotrexate treatment in selected cases of extrauterine pregnancy (EUP) defined by stable or increasing hCG concentration. DESIGN:Prospective cohort study. SETTING:Gynecology department of the Lis Maternity Hospital. PATIENT(S):Fifty women with EUP diagnosed whenever an intraut...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)03256-3
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To assess the minimal effective dose of a GnRH antagonist (Cetrorelix; Asta Medical; Frankfurt, Germany) to prevent premature LH surge in patients undergoing controlled ovarian hyperstimulation (COH) for assisted reproductive technologies. DESIGN:In 69 patients COH was carried out with the association of hMG...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)81407-0
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:To assess the effect of on-demand intranasal oxytocin administration on female sexual function and activity. DESIGN:Randomized, prospective, double-blind, placebo-controlled, crossover trial with duration of 22 weeks. SETTING:Academic medical center. PATIENT(S):Thirty pre-and postmenopausal women with sexu...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2015.06.010
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:To determine whether follicular fluid (FF) cortisol levels affect cumulus cell (CC) lipid content during oocyte meiotic resumption, and whether CCs express genes for glucocorticoid action. DESIGN:Prospective cohort study. SETTING:Academic medical center. PATIENT(S):Thirty-seven nonobese women underwent ova...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2014.09.034
更新日期:2015-01-01 00:00:00
abstract::Appropriate endometrial maturation is of paramount importance to achieve reproductive success. Practical and ethical considerations require that in vitro methods be available to evaluate regulation of human endometrial function. Additionally, tissue complexity requires separation of individual cell populations. This r...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53160-4
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty. DESIGN:Cholesterol or T (n = 6 per group) implants were placed SC in female rhesus macaques beginnin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.11.045
更新日期:2016-04-01 00:00:00
abstract::Two hundred thirteen testicular specimens of men with nonobstructive azoospermia were obtained by large-needle percutaneous aspiration biopsy. The mean values of the number of seminiferous tubules per histologic section, dimension, weight, and the fraction of biopsies with spermatogenetic cells (53, 0.2 x 0.3 x 0.62 c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.12.053
更新日期:2006-08-01 00:00:00
abstract::To assess whether procedures of semen preparation can reduce the proportion of antibody-coated spermatozoa, semen samples with positive direct mixed antiglobulin reaction (MAR) were washed in media supplemented with 10% or 50% fetal cord serum (FCS). Washing reduced the MAR to a negative level, but the MAR was identic...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53169-0
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:To study fertility among women treated by means of ultrasound-guided drainage and antibiotics for tubo-ovarian abscess (TOA). DESIGN:Retrospective cohort study. SETTING:A tertiary referral center. PATIENT(S):One hundred women of reproductive age treated for TOA between June 1986 and July 2003. INTERVENTIO...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.03.054
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To investigate the IVF outcome for patients with endometriosis. DESIGN:Meta-analysis. SETTING:Academic research center. PATIENT(S):A MEDLINE search and review of the literature were performed. Patients were classified by level of endometriosis, and controls were classified according to the indication for I...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/s0015-0282(02)03112-6
更新日期:2002-06-01 00:00:00
abstract::Peritoneal fluid and serum were collected from 78 patients at the time of laparoscopy. Twenty-two were fertile controls (CTL), and 56 were infertility patients, who were subdivided into three main groups: endometriosis (EMS), pelvic adhesions (ADH), and ovarian dysfunction (OvDF). Based on control group data, biochemi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48020-9
更新日期:1984-08-01 00:00:00
abstract:OBJECTIVE:To develop a baseline for projected studies of a rat endometriosis model. DESIGN:We investigated the effects of two macrophage-related growth factors, platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta), on proliferation, in vitro differentiation, and protein secretion of ute...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Levels of specific antibodies against model antigens, immunoglobulins G and A and also albumin, in oviductal fluid were studied in the rhesus monkey during the periovulatory period. Animals were systemically or intravaginally immunized against T4 coliphages. Attempts to induce ovulation were made with human menopausal...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVE:To examine the implantation potential of embryos from assisted reproductive technology cycles with low embryo production and to assess the effects of clinical variables and embryo scores (ES) on pregnancy outcome. DESIGN:Prospective clinical study. SETTING:Assisted reproductive technology unit in a tertiary...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.05.011
更新日期:2003-12-01 00:00:00
abstract::Twenty-seven patients underwent ultrasonographic and clinical monitoring of a spontaneous cycle so that human chorionic gonadotropin administration could be timed in an attempt to schedule the screening laparoscopy at the optimal time for oocyte aspiration. Inadequate ovarian access was encountered in only 2 of 26 lap...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46871-8
更新日期:1983-03-01 00:00:00
abstract::In a rat model, sodium carboxymethylcellulose (SCMC) was compared with normal saline and 32% dextran 70 in the prevention of surgically induced intraperitoneal adhesions. The 32% dextran 70 was similar to normal saline in the initial prevention of adhesions, and both appeared less effective than SCMC. After lysis of t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47910-0
更新日期:1984-06-01 00:00:00
abstract::The International Committee Monitoring Assisted Reproductive Technologies (ICMART) is an independent international nonprofit organization that has taken a leading role in the development, collection, and dissemination of worldwide data on assisted reproductive technology (ART). Information on availability, efficacy, a...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2006.04.018
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To determine the genetic cause of primary amenorrhea. DESIGN:Case series. SETTING:Pediatric endocrinology, endocrinology, and gynecology departments of academic hospitals. PATIENT(S):Three adolescents and one young woman 46, XY patients with srd5A2 gene mutations. MAIN OUTCOME MEASURE(S):Genetic analysis ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.08.007
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that plasma visfatin concentrations will be higher in women with polycystic ovary syndrome (PCOS) than in women without PCOS. DESIGN:Clinical study. SETTING:University hospital. PATIENT(S):A total of 52 women were evaluated. Twenty-six had PCOS, and the remaining 26 were healthy wome...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2006.11.120
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To establish an intracytoplasmic sperm injection treatment program for couples with male infertility and to determine those factors important for success. DESIGN:A retrospective analysis of 171 consecutive cycles of intracytoplasmic sperm injection concerning 145 infertile couples. SETTING:Infertility clini...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57489-5
更新日期:1995-04-01 00:00:00