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Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization.

Abstract：

OBJECTIVE:To determine whether follicular fluid (FF) cortisol levels affect cumulus cell (CC) lipid content during oocyte meiotic resumption, and whether CCs express genes for glucocorticoid action. DESIGN:Prospective cohort study. SETTING:Academic medical center. PATIENT(S):Thirty-seven nonobese women underwent ovarian stimulation for in vitro fertilization (IVF). INTERVENTION(S):At oocyte retrieval, FF was aspirated from the first follicle (>16 mm in size) of each ovary and pooled CCs were collected. MAIN OUTCOME MEASURE(S):Follicular fluid cortisol and cortisone analysis was performed with the use of liquid chromatography-tandem mass spectrometry. CCs were stained with lipid fluorescent dye Bodipy FL C16 to determine lipid content with the use of confocal microscopy. Quantitative real-time polymerase chain reaction was used to detect CC gene expression of 11β-hydroxysteroid dehydrogenase (11β-HSD) types 1 and 2, glucocorticoid receptor (NR3C1), lipoprotein lipase (LPL), and hormone-sensitive lipase (HSL). RESULT(S):Adjusting for maternal age, FF cortisol levels negatively correlated with CC lipid content and positively correlated with numbers of total and mature oocytes. CCs expressed genes for 11β-HSD type 1 as the predominant 11β-HSD isoform, NR3C1, LPL, and HSL. CONCLUSION(S):FF cortisol levels may regulate CC lipolysis during oocyte meiotic resumption and affect oocyte quality during IVF.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Simerman AA,Hill DL,Grogan TR,Elashoff D,Clarke NJ,Goldstein EH,Manrriquez AN,Chazenbalk GD,Dumesic DA

doi

10.1016/j.fertnstert.2014.09.034

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

249-57

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)02211-0

journal_volume

103

pub_type

临床试验,杂志文章

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