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Effects of tibolone and continuous combined hormone replacement therapy on parameters in the clotting cascade: a multicenter, double-blind, randomized study.

Abstract：

OBJECTIVE:To determine the effects of tibolone and continuous combined HRT (ccHRT) on parameters in the clotting cascade. DESIGN:Randomized, double-blind study. SETTING:Hemostasis unit of a university hospital clinic in Germany. PATIENT(S):Sixty healthy postmenopausal women. INTERVENTION(S):Twenty-nine subjects were treated with tibolone (2.5 mg/d) and 31 with oral ccHRT containing estradiol (2 mg/d) + estriol (1 mg/d) + norethindrone acetate (1 mg/d). MAIN OUTCOME MEASURE(S):Effects on parameters in the clotting cascade at baseline and after 12 and 24 weeks of treatment. RESULT(S):Tibolone increased fibrinolysis parameters without significantly altering coagulation parameters. Treatment with ccHRT resulted in a stimulating effect on parameters of both fibrinolysis and coagulation. Tibolone showed a stronger reduction of factor VII activity; less reduction of AT-III, protein C activity, and protein S activity; stronger increase of the activated partial thromboplastin time, plasminogen and plasminogen-antiplasminogen complexes; and less increase of D-Dimer than ccHRT. Both preparations similarly reduced climacteric complaints, whereas tibolone showed less breast complaints than ccHRT. CONCLUSION(S):This study confirms that tibolone, and to a lesser extent also ccHRT, changes hemostasis parameters toward a more fibrinolytic profile, which may diminish the risk of venous thrombosis.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Winkler UH,Altkemper R,Kwee B,Helmond FA,Coelingh Bennink HJ

doi

10.1016/s0015-0282(00)00587-2

keywords:

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

10-9

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(00)00587-2

journal_volume

74

pub_type

临床试验,杂志文章,多中心研究,随机对照试验

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