Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting


OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ultralow AMH values. INTERVENTION(S):Linear and logistic regression, comparison with age-matched cycles with normal AMH concentrations. MAIN OUTCOME MEASURE(S):Cancellation rate; number of retrieved oocytes, embryos, transferred embryos, and cryopreserved embryos; clinical pregnancy, live-birth, and multiple birth rates. RESULT(S):The total cancellation rate per cycle start for fresh cycles was 54%. Of these, 38.6% of the cycles were canceled before retrieval, and 3.3% of cycles obtained no oocytes at time of retrieval. Of all retrieval attempts, 50.7% had three oocytes or fewer retrieved, and 25.1% had no embryo transfer. The live-birth rates were 9.5% per cycle start. Cycles with ultralow AMH levels compared with age-matched normal AMH cycles demonstrated more than a fivefold greater pre-retrieval cancellation rate, a twofold less live-birth rate per cycle and a 4.5-fold less embryo cryopreservation rate. CONCLUSION(S):Refusing treatment solely on the basis of ultralow AMH levels is not advisable, but patients should be counseled appropriately about the prognostic factors for cancellation and outcomes.


Fertil Steril


Fertility and sterility


Seifer DB,Tal O,Wantman E,Edul P,Baker VL




Has Abstract


2016-02-01 00:00:00














  • Occult abnormal pregnancies after first post-embryo transfer serum beta-human chorionic gonadotropin levels of 1.0-5.0 mIU/mL.

    abstract:OBJECTIVE:To assess the occult pregnancy rate after "negative" first post-embryo transfer (ET) serum β-hCG results. DESIGN:Two-part retrospective cohort study and nested case series. SETTING:University-based fertility center. PATIENT(S):A total of 1,571 negative first post-ET serum β-hCG results were included in the...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Maslow BS,Bartolucci A,Sueldo C,Engmann L,Benadiva C,Nulsen JC 3rd

    更新日期:2016-04-01 00:00:00

  • Mindfulness-Based Program for Infertility: efficacy study.

    abstract:OBJECTIVE:To present and determine the impact of the Mindfulness-Based Program for Infertility (MBPI). DESIGN:Controlled clinical trial. SETTING:University research unit. PATIENT(S):Fifty-five infertile women completed the MBPI, and 37 infertile women were assigned to a control group. INTERVENTION(S):The MBPI inclu...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Galhardo A,Cunha M,Pinto-Gouveia J

    更新日期:2013-10-01 00:00:00

  • Intrauterine insemination-ready versus conventional semen cryopreservation for donor insemination: a comparison of retrospective results and a prospective, randomized trial.

    abstract:OBJECTIVE:To compare fecundity rates following intrauterine insemination (IUI) with donor sperm frozen conventionally versus an IUI-ready preparation. DESIGN:Both retrospective results and a prospective, randomized study where recipients were assigned to one of two sperm cryopreservation methods in each cycle of intra...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wolf DP,Patton PE,Burry KA,Kaplan PF

    更新日期:2001-07-01 00:00:00

  • Improving posttransplantation survival of human ovarian tissue by treating the host and graft.

    abstract:OBJECTIVE:To improve posttransplantation survival of frozen-thawed human ovarian tissue in immunodeficient mice. DESIGN:Histologic study of transplanted human ovaries after treating the host and graft. SETTING:Infertility unit, university-affiliated tertiary medical center. PATIENT(S):Ovarian tissue from six girls/w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Abir R,Fisch B,Jessel S,Felz C,Ben-Haroush A,Orvieto R

    更新日期:2011-03-15 00:00:00

  • Recommended practices for the management of embryology, andrology, and endocrinology laboratories: a committee opinion.

    abstract::This document provides a general overview for physicians of the qualities and conditions necessary for good management practices within the endocrinology, andrology, and embryology laboratories in the United States. It is intended as an addendum to previously published guidelines that further detail these responsibili...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引,评审


    authors: Practice Committee of the American Society for Reproductive Medicine.,Practice Committee of the Society for Assisted Reproductive Technology.,Practice Committee of the Society of Reproductive Biologists and Technologists.

    更新日期:2014-10-01 00:00:00

  • Ovarian reserve, response to gonadotropins, and oocyte maturity in women with malignancy.

    abstract:OBJECTIVE:To study the ovarian reserve, ovarian response to gonadotropins, and oocyte maturity in women with cancer undergoing in vitro fertilization (IVF) before chemotherapy or radiotherapy. DESIGN:Case-control study. SETTING:University teaching hospital. PATIENT(S):We evaluated all women with malignancy who under...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Das M,Shehata F,Moria A,Holzer H,Son WY,Tulandi T

    更新日期:2011-07-01 00:00:00

  • Obstetric and perinatal outcomes of pregnancies conceived with embryos cultured in a time-lapse monitoring system.

    abstract:OBJECTIVE:To compare obstetric and perinatal outcomes of singleton pregnancies resulting from embryos incubated in a time-lapse system (TLS) with those of embryos grown in standard IVF incubators (SI). DESIGN:Retrospective description of a cohort of patients who conceived during a randomized, controlled trial. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Insua MF,Cobo AC,Larreategui Z,Ferrando M,Serra V,Meseguer M

    更新日期:2017-09-01 00:00:00

  • The relationship between total motile sperm count and the success of intrauterine insemination.

    abstract:OBJECTIVES:To determine if the total motile sperm count is predictive of IUI success and to apply life-table analysis to a large database of IUI procedures. DESIGN:Contingency table and life-table analyses were used to analyze a large group of couples (n = 546) undergoing 1,205 cycles of therapeutic IUI with husband's...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brasch JG,Rawlins R,Tarchala S,Radwanska E

    更新日期:1994-07-01 00:00:00

  • Evidence for association of the G1733A polymorphism of the androgen receptor gene with recurrent spontaneous abortions.

    abstract:OBJECTIVE:To determine whether the G1733A polymorphism of the androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). DESIGN:Case-control study. SETTING:Division of Genetics and Biotechnology, Department of Biology, University of Athens. PATIENT(S):A total of 131 women w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Karvela M,Stefanakis N,Papadopoulou S,Tsitilou SG,Tsilivakos V,Lamnissou K

    更新日期:2008-11-01 00:00:00

  • Vitrification and xenografting of human ovarian tissue.

    abstract:OBJECTIVE:To assess the efficiency of two vitrification protocols to cryopreserve human preantral follicles with the use of a xenografting model. DESIGN:Pilot study. SETTING:Gynecology research unit in a university hospital. PATIENT(S):Ovarian biopsies were obtained from seven women aged 30-41 years. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Amorim CA,Dolmans MM,David A,Jaeger J,Vanacker J,Camboni A,Donnez J,Van Langendonckt A

    更新日期:2012-11-01 00:00:00

  • Aromatase inhibitor letrozole: a novel treatment for ectopic pregnancy.

    abstract:OBJECTIVE:To study the use of the aromatase inhibitor letrozole for treatment of ectopic pregnancy compared with methotrexate. DESIGN:Nonrandomized prospective cohort study. SETTING:University hospital. PATIENT(S):A series of 42 consecutive patients with undisturbed ectopic pregnancy. INTERVENTION(S):Counseling on ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mitwally MF,Hozayen WG,Hassanin KMA,Abdalla KA,Abdalla NK

    更新日期:2020-08-01 00:00:00

  • Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis.

    abstract:OBJECTIVE:To investigate the role(s) of hyaluronan synthase 2 (HAS2) and hyaluronan in disease progression of endometriosis and epidermal growth factor (EGF)-induced motility changes of endometriotic cells. DESIGN:A case-control experimental study and in vitro primary cell culture study. SETTING:University hospital-a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhan H,Peng B,Ma J,Lin K,Xu K,Lin J,Yong PJ,Leung PCK,Bedaiwy MA,Lin J

    更新日期:2020-10-01 00:00:00

  • Image in reproductive medicine. Cesarean scar ectopic pregnancy.

    abstract::Bilateral hypogastric artery ligation followed by dilatation and evacuation under laparoscopic guidance was successful in the treatment of an advanced cesarean scar ectopic pregnancy. This case presents images of ultrasound, magnetic resonance imaging, and gross anatomy unique to cesarean scar pregnancy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kung FT,Huang TL,Chen CW,Cheng YF

    更新日期:2006-05-01 00:00:00

  • Simple determination of human sperm DNA fragmentation with an improved sperm chromatin dispersion test.

    abstract:OBJECTIVE:To improve the sperm chromatin dispersion (SCD) test and develop it as a simple kit (Halosperm kit) for the accurate determination of sperm DNA fragmentation using conventional bright-field microscopy. DESIGN:Method development, comparison, and validation. SETTING:Medical genetics laboratory, academic biolo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fernández JL,Muriel L,Goyanes V,Segrelles E,Gosálvez J,Enciso M,LaFromboise M,De Jonge C

    更新日期:2005-10-01 00:00:00

  • Nerve fibers in ovarian dermoid cysts and endometriomas.

    abstract::No nerve fibers are found in endometriomas or in the endometrioma-containing ovaries. These findings are consistent with our previous report that no correlation exists between the presence of nerve fibers and endometriosis. ...

    journal_title:Fertility and sterility

    pub_type: 信件


    authors: Al-Fozan H,Bakare S,Chen MF,Tulandi T

    更新日期:2004-07-01 00:00:00

  • Decreased sperm motility is associated with air pollution in Salt Lake City.

    abstract:OBJECTIVE:To study the correlation between indices of air pollution and sperm parameters. DESIGN:Ecological study. SETTING:Contained geographic area. PATIENT(S):Resident men presenting for semen analysis or artificial insemination. INTERVENTION(S):Analysis of levels of particulate air pollution (particulate matter ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hammoud A,Carrell DT,Gibson M,Sanderson M,Parker-Jones K,Peterson CM

    更新日期:2010-04-01 00:00:00

  • An examination of blood steroid and gonadotropin concentrations in relation to fertility status and testicular function in men.

    abstract::Plasma concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), and 17 beta-estradiol (E2) have been measured in men complaining of infertility in comparison with men of proven fertility. Subgrouping of patients was achieved on the basis of the presence or abse...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pierrepoint CG,Jenkins BM,Wilson DW,Phillips MJ,Gow JG

    更新日期:1982-10-01 00:00:00

  • Superoxide anion in human semen related to seminal parameters and clinical aspects.

    abstract:OBJECTIVE:To study the possible presence of extracellular superoxide anion (O2-) in untreated semen of normal and pathological subjects and to determine the possible relationship between superoxide anion levels, number of seminal leukocytes (WBCs) and seminal parameters. PATIENTS:Semen samples were analyzed from ferti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mazzilli F,Rossi T,Marchesini M,Ronconi C,Dondero F

    更新日期:1994-10-01 00:00:00

  • Febrile morbidity following hysterosalpingography: identification of risk factors and recommendations for prophylaxis.

    abstract::Although previous large series have reported that from 0.3% to 1.3% of patients undergoing hysterosalpingography (HSG) develop infectious morbidity, our impression was that the incidence was higher among our patients. Therefore the records of 448 consecutive healthy women who underwent HSG were examined. Within 24 hou...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Stumpf PG,March CM

    更新日期:1980-05-01 00:00:00

  • Tools for making correct decisions regarding hormone therapy. part I: background and drugs.

    abstract:OBJECTIVE:To review existing scientific data related to the biology of estrogen in the aging process of women, and to understand the pharmacology, physiology, and diversity of sex hormones. DESIGN:A MEDLINE computer search was performed to identify relevant articles. RESULT(S):Estrogen and progesterone have been pres...

    journal_title:Fertility and sterility

    pub_type: 历史文章,杂志文章,评审


    authors: Shoham Z,Kopernik G

    更新日期:2004-06-01 00:00:00

  • Can intracytoplasmic morphologically selected sperm injection be used to select normal-sized sperm heads in infertile patients with macrocephalic sperm head syndrome?

    abstract:OBJECTIVE:To study the chromosomal content of spermatozoa selected by intracytoplasmic morphologically selected sperm injection (IMSI) in cases of macrocephalic sperm head syndrome. DESIGN:Case report. SETTING:Obstetrics, gynecology, urology, and reproductive biology departments. PATIENT(S):Two infertile patients wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chelli MH,Albert M,Ray PF,Guthauser B,Izard V,Hammoud I,Selva J,Vialard F

    更新日期:2010-03-01 00:00:00

  • Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway.

    abstract:OBJECTIVE:To explore the relationship between men's age and DNA damage repair proteins related to apoptosis in human testicular germ cells. DESIGN:Retrospective case-control study. SETTING:Academic institutions. PATIENT(S):Testicular specimens were obtained from 22 fertile volunteers aged 20-82 years. INTERVENTION(...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: El-Domyati MM,Al-Din AB,Barakat MT,El-Fakahany HM,Xu J,Sakkas D

    更新日期:2009-05-01 00:00:00

  • Sperm DNA fragmentation and mitochondrial membrane potential combined are better for predicting natural conception than standard sperm parameters.

    abstract:OBJECTIVE:To evaluate whether DNA fragmentation and/or mitochondrial membrane potential (MMP) predict natural conception better than standard sperm parameters. DESIGN:Prospective cross-sectional study. SETTING:University medical center. PATIENT(S):Eighty-five infertile and 51 fertile men. INTERVENTION(S):Assessment...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Malić Vončina S,Golob B,Ihan A,Kopitar AN,Kolbezen M,Zorn B

    更新日期:2016-03-01 00:00:00

  • Sperm motility assessment by videomicrography.

    abstract::A technically simple, inexpensive method is described for measuring objective parameters of sperm motility. The instruments involved are commercially available, home-oriented videotape equipment. Quantitative measurements of sperm motility are made directly from the video image and are facilitated by use of an analysi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Katz DF,Overstreet JW

    更新日期:1981-02-01 00:00:00

  • Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus.

    abstract:OBJECTIVE:To evaluate the effects of the immunosuppressant tacrolimus on rejection of a transplanted uterus and on uterine expression of markers of inflammation and implantation. DESIGN:Experimental study. SETTING:University laboratory. ANIMAL(S):Female rats. INTERVENTION(S):Uteri from brown Norway rats were transp...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Akhi SN,Diaz-Garcia C,El-Akouri RR,Wranning CA,Mölne J,Brännström M

    更新日期:2013-03-01 00:00:00

  • Sexuality after sigmoid vaginoplasty in patients with Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract:OBJECTIVE:To investigate the functional and sexual outcome of sigmoid vaginoplasty in patients with Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. DESIGN:Prospective study. SETTING:University hospital. PATIENT(S):Fifty-nine consecutive patients with MRKH syndrome. INTERVENTION(S):Forty-eight patients underwent sig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Carrard C,Chevret-Measson M,Lunel A,Raudrant D

    更新日期:2012-03-01 00:00:00

  • Developmental potential of fully intact and partially damaged cryopreserved embryos after laser-assisted removal of necrotic blastomeres and post-thaw culture selection.

    abstract:OBJECTIVE:Partially damaged frozen and thawed embryos are currently considered to have a lower viability than intact ones. This study was undertaken to compare the performance of intact frozen and thawed embryos with that of partially damaged embryos after removal of the necrotic blastomeres. DESIGN:Observational clin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Rienzi L,Ubaldi F,Iacobelli M,Minasi MG,Romano S,Ferrero S,Sapienza F,Baroni E,Tesarik J,Greco E

    更新日期:2005-10-01 00:00:00

  • Results of artificial insemination at home by the partner with cryopreserved donor semen: a randomized study.

    abstract::The use of cryopreserved semen offers the possibility of home insemination by the instructed partner. A comparative study was designed whereby participants were randomly allocated to use home or clinic insemination for six cycles. If no pregnancy had occurred after six cycles, the site of insemination was switched to ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hogerzeil HV,Hamerlynck JV,van Amstel N,Nagelkerke NJ,Lammes FB

    更新日期:1988-06-01 00:00:00

  • Assessment of testicular cytology by fine needle aspiration as a diagnostic parameter in the evaluation of the azoospermic subject.

    abstract:OBJECTIVE:To investigate whether testicular cytology by fine needle aspiration (FNA) may be considered a diagnostic parameter in the evaluation of the azoospermic subject. DESIGN:Cytologic smears were obtained using a 23-G needle, stained with May-Grünwald-Giemsa stain and examined under a light Orthoplan microscope (...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Foresta C,Varotto A,Scandellari C

    更新日期:1992-04-01 00:00:00

  • Male immunologic infertility: sperm performance on in vitro fertilization.

    abstract:OBJECTIVE:To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. DESIGN:Retrospective clinical study. SETTING:Patients attending a private IVF clinic. PATIENT(S):The study group comprised seven men with significant levels of surface-bound antisperm antibodies treat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vazquez-Levin MH,Notrica JA,Polak de Fried E

    更新日期:1997-10-01 00:00:00