Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting


OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ultralow AMH values. INTERVENTION(S):Linear and logistic regression, comparison with age-matched cycles with normal AMH concentrations. MAIN OUTCOME MEASURE(S):Cancellation rate; number of retrieved oocytes, embryos, transferred embryos, and cryopreserved embryos; clinical pregnancy, live-birth, and multiple birth rates. RESULT(S):The total cancellation rate per cycle start for fresh cycles was 54%. Of these, 38.6% of the cycles were canceled before retrieval, and 3.3% of cycles obtained no oocytes at time of retrieval. Of all retrieval attempts, 50.7% had three oocytes or fewer retrieved, and 25.1% had no embryo transfer. The live-birth rates were 9.5% per cycle start. Cycles with ultralow AMH levels compared with age-matched normal AMH cycles demonstrated more than a fivefold greater pre-retrieval cancellation rate, a twofold less live-birth rate per cycle and a 4.5-fold less embryo cryopreservation rate. CONCLUSION(S):Refusing treatment solely on the basis of ultralow AMH levels is not advisable, but patients should be counseled appropriately about the prognostic factors for cancellation and outcomes.


Fertil Steril


Fertility and sterility


Seifer DB,Tal O,Wantman E,Edul P,Baker VL




Has Abstract


2016-02-01 00:00:00














  • Effect of ovariectomy on the gene expression of detrusor muscarinic receptors in female rats.

    abstract::Eight rats served as control subjects with sham surgeries and eight rats underwent ovariectomy. Two months later, the expression of muscarinic receptors, neuronal nitric oxide synthase (nNOS), and estrogen receptor (R) at the mRNA level were assessed by reverse-transcription polymerase chain reaction. The results show...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Long CY,Hsu CS,Shao PL,Liu CM,Su JH,Tsai EM

    更新日期:2009-09-01 00:00:00

  • Brown oocytes: implications for assisted reproductive technology.

    abstract::Fertilization, embryo development, and successful pregnancy can be achieved after transfer of embryos derived from brown oocytes at the same rate as embryos from morphologically normal oocytes. Therefore, brown oocytes are probably normal and this morphological criterion does not seem to be indicative of any adverse o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Esfandiari N,Burjaq H,Gotlieb L,Casper RF

    更新日期:2006-11-01 00:00:00

  • Regret after decision to have a tubal sterilization.

    abstract::To determine characteristics associated with regretting sterilization that can be determined preoperatively, we analyzed data from the Collaborative Review of Sterilization (CREST), a multicenter, prospective, observational study. Of 5022 women, 2.0% regretted having had a tubal sterilization at 1 year after the proce...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Grubb GS,Peterson HB,Layde PM,Rubin GL

    更新日期:1985-08-01 00:00:00

  • Laparoscopic metroplasty: reconstructive surgery for unicornuate uterus with noncommunicating, functional uterine horn.

    abstract:OBJECTIVE:To demonstrate laparoscopic surgery for a patient with unicornuate uterus and a large hematometra in the noncommunicating uterine horn. DESIGN:Narrated video featuring the diagnostic tests and surgical management. SETTING:Academic tertiary hospital. PATIENT(S):A 13-year-old woman, gravida 0 with menarche a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yen CF,Hsin-Yu Pai A,Lo A,Chueh HY,Huang HY,Lin SL

    更新日期:2020-11-01 00:00:00

  • Vitrification and xenografting of human ovarian tissue.

    abstract:OBJECTIVE:To assess the efficiency of two vitrification protocols to cryopreserve human preantral follicles with the use of a xenografting model. DESIGN:Pilot study. SETTING:Gynecology research unit in a university hospital. PATIENT(S):Ovarian biopsies were obtained from seven women aged 30-41 years. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Amorim CA,Dolmans MM,David A,Jaeger J,Vanacker J,Camboni A,Donnez J,Van Langendonckt A

    更新日期:2012-11-01 00:00:00

  • Use of letrozole versus clomiphene citrate combined with gonadotropins in intrauterine insemination cycles: a pilot study.

    abstract:OBJECTIVE:To compare the clinical outcomes between letrozole and clomiphene citrate (CC) in gonadotropin-combined intrauterine insemination (IUI) cycles. DESIGN:Prospective pilot study. SETTING:One university hospital and two private infertility clinics. PATIENT(S):Ninety-three infertile couples eligible for superov...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Jee BC,Ku SY,Suh CS,Kim KC,Lee WD,Kim SH

    更新日期:2006-06-01 00:00:00

  • Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans.

    abstract::The association of insulin resistance, hyperandrogenism, and acanthosis nigricans is well established. The ovary is thought to be the site of the excess androgen production. The purpose of this study was to assess the adrenal contribution to the hyperandrogenic state in these women. Twenty-three patients presenting wi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Alper MM,Garner PR

    更新日期:1987-02-01 00:00:00

  • A prospective randomized comparison of luteal phase versus concurrent follicular phase initiation of gonadotropin-releasing hormone agonist for in vitro fertilization.

    abstract:OBJECTIVE:To compare the effects of gonadotropin-releasing hormone agonist (GnRH-a) initiation either preceding or concurrent with controlled ovarian hyperstimulation (COH) in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). DESIGN:Fifty-five patients were prospectively randomized to receive either...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: San Roman GA,Surrey ES,Judd HL,Kerin JF

    更新日期:1992-10-01 00:00:00

  • Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To determine plasma adiponectin concentration in women with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin to the hormonal and metabolic parameters, including measures of insulin resistance (IR). DESIGN:Case-control study. SETTING:Tertiary-referral university...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ardawi MS,Rouzi AA

    更新日期:2005-06-01 00:00:00

  • Complications of medically assisted conception in 3,500 cycles.

    abstract:OBJECTIVE:To investigate the incidence of complications in the use of assisted reproductive technology in the management of infertile couples. DESIGN:Retrospective study. SETTING:The Egyptian IVF & ET Center, Maadi, Cairo, Egypt. PATIENT(S):Two thousand nine hundred twenty-four patients underwent IVF-ET or intracyto...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Serour GI,Aboulghar M,Mansour R,Sattar MA,Amin Y,Aboulghar H

    更新日期:1998-10-01 00:00:00

  • Anesthesia for diagnostic and operative laparoscopy.

    abstract::Laparoscopic sterilization was performed on 50 racially distributed patients, aged 18-42 years, who were selected at random from the Outpatient Laparoscope Sterilization Clinic and offered sterilization under local anesthesia. The patients were injected with a systemic analgesic as well as a local anesthetic. One in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wheeless CR Jr

    更新日期:1971-10-01 00:00:00

  • Selective insulin-like growth factor-I antagonist inhibits mouse embryo development in a dose-dependent manner.

    abstract:OBJECTIVE:To study the role of a synthetic insulin-like growth factor-I receptor (IGF-IR) antagonist, picropodophyllin, for mouse preimplantation embryo development in vivo and in vitro. DESIGN:In vitro and in vivo study. SETTING:Hospital-based research unit. ANIMALS:FVB/N mice and mouse embryos. INTERVENTION(S):Th...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Inzunza J,Danielsson O,Lalitkumar PG,Larsson O,Axelson M,Töhönen V,Danielsson KG,Stavreus-Evers A

    更新日期:2010-05-15 00:00:00

  • Cosmetics use and age at menopause: is there a connection?

    abstract::Cosmetics contain a vast number of chemicals, most of which are not under the regulatory purview of the Food and Drug Administration. Only a few of these chemicals have been evaluated for potential deleterious health impact: parabens, phthalates, polycyclic aromatic hydrocarbons, and siloxanes. A review of the ingredi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Chow ET,Mahalingaiah S

    更新日期:2016-09-15 00:00:00

  • Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To investigate the relative differences in outcomes among microdissection testicular sperm extraction (micro-TESE), conventional testicular sperm extraction (cTESE), and testicular sperm aspiration (TESA) in men with nonobstructive azoospermia. DESIGN:Systematic review and meta-analysis. SETTING:Outpatient ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Bernie AM,Mata DA,Ramasamy R,Schlegel PN

    更新日期:2015-11-01 00:00:00

  • Introduction: Continuing story of premature progesterone elevation.

    abstract::Since the late 1980s premature progesterone elevation has repeatedly caught the attention of investigators, not only for its importance, but also because studies have shown differing results and conclusions, constituting an unexplainable sequence of doubts and uncertainties. This issue's Views and Reviews section seek...

    journal_title:Fertility and sterility



    authors: Fanchin R

    更新日期:2018-04-01 00:00:00

  • Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study.

    abstract::The aim of this study was to investigate the effects of pure genistein therapy on asymmetric dimethylarginine in healthy postmenopausal women. Healthy postmenopausal women received pure genistein (n=21) or placebo (n=17) for 6 months, and no statistically significant effects on plasma asymmetric dimethylarginine level...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Kaygusuz I,Turhan NO,Duvan CI,Koca C,Aydin M

    更新日期:2010-07-01 00:00:00

  • Deoxyribonucleic acid polymerase activity in the testes of infertile men with varicocele.

    abstract::Activities of deoxyribonucleic acid (DNA) polymerase alpha, beta, and gamma were measured in extracts of testicular biopsy specimen obtained from 37 cases of male infertility with left varicocele and compared with those of 6 normal controls. It was observed that levels of DNA polymerase alpha, beta, and gamma were sig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fujisawa M,Yoshida S,Matsumoto O,Kojima K,Kamidono S

    更新日期:1988-11-01 00:00:00

  • Prognostic factors in oocyte donation: an analysis through egg-sharing recipient pairs showing a discordant outcome.

    abstract:OBJECTIVE:To analyze prognostic factors that are associated with a discordant outcome in egg recipients sharing oocytes from the same donor. DESIGN:Matched case-control single-center study. SETTING:Private infertility clinic. PATIENT(S):Four hundred forty-four recipients (222 pairs) sharing oocytes from the same don...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bodri D,Colodron M,Vidal R,Galindo A,Durban M,Coll O

    更新日期:2007-12-01 00:00:00

  • Gonadotropin requirements of the developing follicle.

    abstract:OBJECTIVE:To evaluate follicular FSH and LH requirements during suppression of endogenous gonadotropins with the GnRH antagonist Nal-Glu and whether LH-like activity could be supplied by administering subcutaneous hCG. DESIGN:Randomized clinical trial. PARTICIPANTS:Thirty-two normally cycling females in the late foll...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Thompson KA,LaPolt PS,River J,Henderson G,Dahl KD,Meldrum DR

    更新日期:1995-02-01 00:00:00

  • No increase in arteriolosclerotic retinopathy or activity in tests for circulating immune complexes 5 years after vasectomy.

    abstract::On the basis of studies in monkeys, the hypothesis has been proposed that vasectomy induces the formation of circulating immune complexes (CICs), which--via activation of the complement system--may result in immune injury of the endothelium and thereby exacerbate atherosclerosis; the same mechanism has been suggested ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Linnet L,Møller NP,Bernth-Petersen P,Ehlers N,Brandslund I,Svehag SE

    更新日期:1982-06-01 00:00:00

  • Mild endometriosis and ovulatory dysfunction: effect of danazol treatment on success of ovulation induction.

    abstract::The effectiveness of ovulation induction with clomiphene citrate or human menopausal gonadotropins was evaluated in 52 infertile women with stage I or stage II endometriosis and ovulatory dysfunction: anovulation or luteinized unruptured follicle (LUF) syndrome before (group I) and after (group II) danazol treatment. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dmowski WP,Radwanska E,Binor Z,Rana N

    更新日期:1986-11-01 00:00:00

  • Alterations in progesterone metabolism and luteal function in infertile women with endometriosis.

    abstract::The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum pro...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Cheesman KL,Cheesman SD,Chatterton RT Jr,Cohen MR

    更新日期:1983-11-01 00:00:00

  • Preimplantation genetic diagnosis increases the implantation rate in human in vitro fertilization by avoiding the transfer of chromosomally abnormal embryos.

    abstract:OBJECTIVE:To verify the percentage of chromosomally abnormal preimplantation embryos in patients with a poor prognosis and possibly to increase the chance of implantation by selecting chromosomally normal embryos. DESIGN:A prospective, randomized, controlled study. SETTING:In vitro fertilization program at the Reprod...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gianaroli L,Magli MC,Ferraretti AP,Fiorentino A,Garrisi J,Munné S

    更新日期:1997-12-01 00:00:00

  • Successful treatment of severe endometriosis in two premenopausal women with an aromatase inhibitor.

    abstract:OBJECTIVE:To treat severe endometriosis in premenopausal women with an aromatase inhibitor and to document the efficacy and side effects of this new treatment. DESIGN:Case report. SETTING:Clinical practice setting. PATIENT(S):Patients were premenopausal endometriosis cases confirmed by prior laparoscopy. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Shippen ER,West WJ Jr

    更新日期:2004-05-01 00:00:00

  • Male immunologic infertility: sperm performance on in vitro fertilization.

    abstract:OBJECTIVE:To analyze sperm performance in a group of patients with male immunologic infertility treated with IVF-ET. DESIGN:Retrospective clinical study. SETTING:Patients attending a private IVF clinic. PATIENT(S):The study group comprised seven men with significant levels of surface-bound antisperm antibodies treat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vazquez-Levin MH,Notrica JA,Polak de Fried E

    更新日期:1997-10-01 00:00:00

  • A case of unusual course of adolescent menorrhagia: decidual cast as a side effect of treatment.

    abstract:OBJECTIVE:To present an unusual side effect of therapy for adolescent menorrhagia, with commentary on management options. DESIGN:Case report. SETTING:Tertiary gynecologic center. PATIENT(S):A 13-year-old girl presenting with profuse uterine bleeding. INTERVENTION(S):Dysfunctional uterine bleeding was diagnosed, and...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Torres A,Baszak-Radomańska E,Torres K,Paszkowski T,Staśkiewicz GJ,Wozniakowska E

    更新日期:2009-11-01 00:00:00

  • Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata.

    abstract::There is a paucity of data concerning the factors involved in the growth of uterine leiomyomata. The expression of mRNAs encoding EGF and the EGF receptor in myometrial and leiomyoma cultures suggest that EGF may be involved in the autocrine/paracrine regulation of human uterine leiomyomata and myometrial growth. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yeh J,Rein M,Nowak R

    更新日期:1991-11-01 00:00:00

  • Growth hormone enhances estradiol production follicle-stimulating hormone-induced in the early stage of the follicular maturation.

    abstract:OBJECTIVE:To investigate the ability of GH to increase the steroidogenic response of the ovary to FSH in the early stage of human follicle development in vivo. DESIGN:Ovarian sensitivity to FSH and/or GH during the early follicular phase of the human menstrual cycle was evaluated in a prospective study. SETTING:Norma...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lanzone A,Fortini A,Fulghesu AM,Soranna L,Caruso A,Mancuso S

    更新日期:1996-12-01 00:00:00

  • Antiestrogenic action of high-dose clomiphene in primates pituitary augmentation but with ovarian attenuation.

    abstract::Since the dominant follicle is selected by days 5 to 7 of the menstrual cycle, we assessed the differential effects of high-dose clomiphene (25 mg daily) by giving 5-day courses either before (days 1 to 5), during (days 5 to 9), or after (days 9 to 13) emergence of the selected dominant follicle in monkeys. Peripheral...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Marut EL,Hodgen GD

    更新日期:1982-07-01 00:00:00

  • Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?

    abstract:OBJECTIVE:To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy. DESIGN:Review of English publications in PubMed and Embase to April 6, 2020. METHOD(S):Articles were screened for reports including coronavirus, r...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Segars J,Katler Q,McQueen DB,Kotlyar A,Glenn T,Knight Z,Feinberg EC,Taylor HS,Toner JP,Kawwass JF,American Society for Reproductive Medicine Coronavirus\/COVID-19 Task Force.

    更新日期:2020-06-01 00:00:00