Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting


OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ultralow AMH values. INTERVENTION(S):Linear and logistic regression, comparison with age-matched cycles with normal AMH concentrations. MAIN OUTCOME MEASURE(S):Cancellation rate; number of retrieved oocytes, embryos, transferred embryos, and cryopreserved embryos; clinical pregnancy, live-birth, and multiple birth rates. RESULT(S):The total cancellation rate per cycle start for fresh cycles was 54%. Of these, 38.6% of the cycles were canceled before retrieval, and 3.3% of cycles obtained no oocytes at time of retrieval. Of all retrieval attempts, 50.7% had three oocytes or fewer retrieved, and 25.1% had no embryo transfer. The live-birth rates were 9.5% per cycle start. Cycles with ultralow AMH levels compared with age-matched normal AMH cycles demonstrated more than a fivefold greater pre-retrieval cancellation rate, a twofold less live-birth rate per cycle and a 4.5-fold less embryo cryopreservation rate. CONCLUSION(S):Refusing treatment solely on the basis of ultralow AMH levels is not advisable, but patients should be counseled appropriately about the prognostic factors for cancellation and outcomes.


Fertil Steril


Fertility and sterility


Seifer DB,Tal O,Wantman E,Edul P,Baker VL




Has Abstract


2016-02-01 00:00:00














  • Immature spermatids are not prevalent in semen from men who are receiving androgen-based contraceptive regimens.

    abstract:OBJECTIVE:To determine whether immature spermatids increase in semen in response to hormonal contraceptive treatments. Such a finding would support the existence of a defect in spermiogenesis, which in turn may explain the reported variability in sperm output. DESIGN:Semen smears were obtained from healthy men undergo...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Zhengwei Y,Wreford NG,Bremner WJ,Matsumoto AM,Anawalt BA,McLachlan RI

    更新日期:1998-01-01 00:00:00

  • The acrosomal protein Dickkopf-like 1 (DKKL1) is not essential for fertility.

    abstract:OBJECTIVE:To determine the role of Dkkl1 on mouse development, viability, and fertility. DESIGN:Prospective experimental study. SETTING:Government research institution. ANIMAL(S):Mice of C57BL/6 and 129X1/SvJ strains, as well as transgenic mice of mixed C57BL/6 and 129X1/SvJ strains were used for the studies. INTER...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kaneko KJ,Kohn MJ,Liu C,DePamphilis ML

    更新日期:2010-03-15 00:00:00

  • Impact of fatness, insulin, and gynecological age on luteinizing hormone secretory dynamics in adolescent females.

    abstract:OBJECTIVE:To study the link between fatness and gonadotropin secretion. Overweight status is linked to polycystic ovary syndrome (PCOS) in adolescents. We postulated that heavier adolescents without symptoms would secrete LH with: [1] increased pulse frequency (LHPF) and [2] exaggerated integrated concentrations (LHAUC...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kasa-Vubu JZ,Jain V,Welch K

    更新日期:2010-06-01 00:00:00

  • Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: a randomized, double blind, placebo-controlled trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women. DESIGN:Placebo-controlled, double-blind, randomized trial. SETTING:University hospital. PATIENT(S):Fifty-two women with an indication for diagnostic hysteroscopy. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Mulayim B,Celik NY,Onalan G,Bagis T,Zeyneloglu HB

    更新日期:2010-05-01 00:00:00

  • Penetration of zona-free hamster ova and bovine cervical mucus by fresh and frozen human spermatozoa.

    abstract::Semen samples from 25 fertile donors and 34 infertility patients were analyzed and evaluated both fresh and frozen with the zona-free hamster egg penetration test (EPT) and the bovine cervical mucus penetration test (MPT). Cryopreserved sperm penetrated 47.2% (average) of the hamster eggs, and fresh sperm penetrated 5...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Urry RL,Carrell DT,Hull DB,Middleton RG,Wiltbank MC

    更新日期:1983-05-01 00:00:00

  • Profiling signaling proteins in human spermatozoa: biomarker identification for sperm quality evaluation.

    abstract:OBJECTIVE:To determine the correlation between semen basic parameters and the expression and activity of signaling proteins. DESIGN:In vitro studies with human spermatozoa. SETTING:Academic research institute. PATIENT(S):Thirty-seven men provided semen samples for routine analysis. INTERVENTION(S):None. MAIN OUTCO...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Silva JV,Freitas MJ,Correia BR,Korrodi-Gregório L,Patrício A,Pelech S,Fardilha M

    更新日期:2015-10-01 00:00:00

  • Impact of elagolix treatment on fatigue experienced by women with moderate to severe pain associated with endometriosis.

    abstract:OBJECTIVE:To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. DESIGN:Randomized, double-blind, multicenter, placebo-controlled phase III trial. SETTING:Clinics. PATIENT(S):A total of 860 women treated with elagoli...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Surrey ES,Soliman AM,Agarwal SK,Snabes MC,Diamond MP

    更新日期:2019-08-01 00:00:00

  • The relationship between total motile sperm count and the success of intrauterine insemination.

    abstract:OBJECTIVES:To determine if the total motile sperm count is predictive of IUI success and to apply life-table analysis to a large database of IUI procedures. DESIGN:Contingency table and life-table analyses were used to analyze a large group of couples (n = 546) undergoing 1,205 cycles of therapeutic IUI with husband's...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Brasch JG,Rawlins R,Tarchala S,Radwanska E

    更新日期:1994-07-01 00:00:00

  • Fertilization and embryo cleavage after intracytoplasmic spermatid injection in an obstructive azoospermic patient with defective spermiogenesis.

    abstract:OBJECTIVE:To achieve fertilization and cleavage by spermatids without tails from testicular biopsy. DESIGN:Clinical trial. SETTING:Reproductive unit of a university teaching hospital. PATIENT:A patient of obstructive azoospermia with defective spermiogenesis. INTERVENTION:Testicular biopsy after scrotal exploration...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Chen SU,Ho HN,Chen HF,Tsai TC,Lee TY,Yang YS

    更新日期:1996-07-01 00:00:00

  • Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice.

    abstract:OBJECTIVE:To examine the relationship between an antibody against GAPDH-2, a sperm-specific protein, and infertility of female mice. DESIGN:Basic research. SETTING:National Research Institute for Family Planning Beijing, World Health Organization Collaboration Center of Human Reproduction. ANIMAL(S):New Zealand rabb...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wang Y,Zhang N,Zhang X,Miao S,Zong S,Koide SS,Wang L

    更新日期:2009-12-01 00:00:00

  • Subfertility increases risk of testicular cancer: evidence from population-based semen samples.

    abstract:OBJECTIVE:To further understand the association between semen quality and cancer risk by means of well defined semen parameters. DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):A total of 20,433 men who underwent semen analysis (SA) and a sample of 20,433 fertile control subjects matched by age...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hanson HA,Anderson RE,Aston KI,Carrell DT,Smith KR,Hotaling JM

    更新日期:2016-02-01 00:00:00

  • Characterization of the injection funnel during intracytoplasmic sperm injection reflects cytoplasmic maturity of the oocyte.

    abstract:OBJECTIVE:To quantify cytoplasmic maturity on the basis of intracytoplasmic sperm injection (ICSI) injection funnel manifestation and to evaluate influence factors of the latter. DESIGN:Prospective study. SETTING:Private fertility center. PATIENT(S):A total of 31 patients with good ovarian response. INTERVENTION(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Krause I,Pohler U,Grosse S,Shebl O,Petek E,Chandra A,Ebner T

    更新日期:2016-10-01 00:00:00

  • Ureteral abnormalities in women with endometriosis.

    abstract::High-volume intravenous urography was performed in 63 women with surgically proven endometriosis. Subtle abnormalities were found in 15.9% of these women. No patient had urologic symptoms, and there was no evidence of hydroureter or ureteral obstruction on the IVP. Long-term follow-up study will be required to determi...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Maxson WS,Hill GA,Herbert CM,Kaufman AJ,Pittaway DE,Daniell JF,Winfield AC,Wentz AC

    更新日期:1986-12-01 00:00:00

  • Previous ectopic pregnancy as a predictor of failure of systemic methotrexate therapy.

    abstract:OBJECTIVE:To investigate whether a history of previous ectopic pregnancy is an independent risk factor for failure of methotrexate therapy in subsequent ectopic pregnancies and whether the previous treatment method influenced failure. SETTING:Inner-city teaching hospital. DESIGN:Retrospective case review. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lipscomb GH,Givens VA,Meyer NL,Bran D

    更新日期:2004-05-01 00:00:00

  • Consecutive cervical pregnancies.

    abstract:OBJECTIVE:Report of a rare case of consecutive spontaneous cervical pregnancies. DESIGN:Case study. SETTING:Teaching hospital. PATIENT(S):One healthy nulliparous woman in the early years of her fourth decade. INTERVENTION(S):The first of two cervical pregnancies was treated with two doses of methotrexate and subseq...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Radpour CJ,Keenan JA

    更新日期:2004-01-01 00:00:00

  • Composition of single-step media used for human embryo culture.

    abstract:OBJECTIVE:To determine compositions of commercial single-step culture media and test with a murine model whether differences in composition are biologically relevant. DESIGN:Experimental laboratory study. SETTING:University-based laboratory. ANIMAL(S):Inbred female mice were superovulated and mated with outbred male...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Morbeck DE,Baumann NA,Oglesbee D

    更新日期:2017-04-01 00:00:00

  • Ovarian response in three consecutive in vitro fertilization cycles.

    abstract:OBJECTIVE:This study was designed to assess the ovarian response in the same patient in consecutive IVF cycles. DESIGN:Retrospective study. SETTING:Assisted reproductive unit at a university hospital. PATIENT(S):One hundred ninety women who underwent three consecutive cycles of IVF. INTERVENTION(S):All women used a...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hoveyda F,Engmann L,Steele J,Lopez Bernal A,Barlow DH

    更新日期:2002-04-01 00:00:00

  • Preliminary studies on apoptosis in human fetal ovaries.

    abstract:OBJECTIVE:To evaluate if apoptosis occurs in human germ cells between 19 and 33 gestational weeks (GW). DESIGN:Human fetal ovaries were obtained from aborted fetuses aged 19-33 GW. SETTING:Rabin Medical Center, a major tertiary care and referral center. PATIENT(S):Twenty-seven women undergoing pregnancy termination....

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Abir R,Orvieto R,Dicker D,Zukerman Z,Barnett M,Fisch B

    更新日期:2002-08-01 00:00:00

  • Noninvasive metabolomic profiling of embryo culture media using proton nuclear magnetic resonance correlates with reproductive potential of embryos in women undergoing in vitro fertilization.

    abstract:OBJECTIVE:To identify biomarkers associated with reproductive outcome using proton nuclear magnetic resonance ((1)H NMR) metabolomic profiling of embryo culture media. DESIGN:Retrospective study. SETTING:An academic assisted reproductive technology (ART) program; a university research center. PATIENT(S):Women underg...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Seli E,Botros L,Sakkas D,Burns DH

    更新日期:2008-12-01 00:00:00

  • Epigenetic regulation of an adverse metabolic phenotype in polycystic ovary syndrome: the impact of the leukocyte methylation of PPARGC1A promoter.

    abstract:OBJECTIVE:To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycystic ovary syndrome (PCOS) and analyze the relationship between these indices and metabolic risk for women with PCOS. DESIGN:Cross-sectional study. SETTING:University hospital. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhao H,Zhao Y,Ren Y,Li M,Li T,Li R,Yu Y,Qiao J

    更新日期:2017-02-01 00:00:00

  • Altered ultrastructure of mitochondrial membranes is strongly associated with unexplained asthenozoospermia.

    abstract:OBJECTIVE:To explore the contribution of an altered structure of sperm mitochondria to human asthenozoospermia. DESIGN:A retrospective study. SETTING:Andrology Clinic, University of L'Aquila. PATIENT(S):Fifteen ejaculates with forward motility (FM) ≥ 50%, and 57 asthenozoospermic ejaculates (FM <50%, sperm vitality ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Pelliccione F,Micillo A,Cordeschi G,D'Angeli A,Necozione S,Gandini L,Lenzi A,Francavilla F,Francavilla S

    更新日期:2011-02-01 00:00:00

  • International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2005.

    abstract:OBJECTIVE:To analyze information on assisted reproductive technology (ART) performed worldwide and trends in outcomes over successive years. DESIGN:Cross-sectional survey on access, effectiveness, and safety of ART procedures performed in 53 countries during 2005. SETTING:A total of 2,973 clinics from national and re...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zegers-Hochschild F,Mansour R,Ishihara O,Adamson GD,de Mouzon J,Nygren KG,Sullivan EA

    更新日期:2014-02-01 00:00:00

  • Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cycles.

    abstract:OBJECTIVE:To determine the incidence of ovarian hyperstimulation syndrome (OHSS) in a large series of GnRH antagonist-stimulated cycles and to assess the predictive value of E2 and the number of follicles on the day of hCG administration. DESIGN:Prospective cohort study of women undergoing IVF treatment with a GnRH an...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Papanikolaou EG,Pozzobon C,Kolibianakis EM,Camus M,Tournaye H,Fatemi HM,Van Steirteghem A,Devroey P

    更新日期:2006-01-01 00:00:00

  • Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum.

    abstract::We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Heilier JF,Donnez O,Van Kerckhove V,Lison D,Donnez J

    更新日期:2006-05-01 00:00:00

  • Should embryos developing to blastocysts on day 7 be cryopreserved and transferred: an analysis of pregnancy and implantation rates.

    abstract:OBJECTIVE:To compare pregnancy rates (PRs) using blastocysts cryopreserved on day 7 with those cryopreserved on days 5 and 6. DESIGN:Retrospective observational cohort study. SETTING:Infertility center performing IVF. PATIENT(S):Eight hundred women with infertility undergoing frozen ET. INTERVENTION(S):Blastocysts ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kovalevsky G,Carney SM,Morrison LS,Boylan CF,Neithardt AB,Feinberg RF

    更新日期:2013-10-01 00:00:00

  • Clomiphene citrate intrauterine insemination (IUI) before gonadotropin IUI affects the pregnancy rate and the rate of high-order multiple pregnancies.

    abstract:OBJECTIVE:To determine if previous treatment with clomiphene citrate intrauterine insemination (CC-IUI) affects pregnancy and high-order multiple pregnancy (HOMP) rates in subsequent hMG-IUI or FSH-IUI cycles. DESIGN:Retrospective cohort study. SETTING:Private infertility clinic. PATIENT(S):Five hundred fifty-one pa...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Dickey RP,Taylor SN,Lu PY,Sartor BM,Pyrzak R

    更新日期:2004-03-01 00:00:00

  • Reevaluating response and failure of medical treatment of endometriosis: a systematic review.

    abstract:OBJECTIVE:To assess patient response rates to medical therapies used to treat endometriosis-associated pain. DESIGN:A systematic review with the use of Medline and Embase. SETTING:Not applicable. PATIENT(S):Women receiving medical therapy to treat endometriosis. INTERVENTIONS(S):None. MAIN OUTCOME MEASURE(S):The p...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Becker CM,Gattrell WT,Gude K,Singh SS

    更新日期:2017-07-01 00:00:00

  • Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.

    abstract:OBJECTIVE:To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. DESIGN:Prospective, case-control study. SETTING:Large public hospital in a major city in China. PATIENT(S):Twenty-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Yang H,Qiu L,Chen G,Ye Z,Lü C,Lin Q

    更新日期:2008-03-01 00:00:00

  • Endometrial responses to three different progestins in artificial cycles: a prospective, crossover study.

    abstract::We found that there was no significant difference in endometrial responses to vaginal or IM P. But the response was suboptimal in cycles treated with dydrogesterone, suggesting that dydrogesterone treatment is not the preferred progestin for use in artificial cycles. ...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Li TC,Aplin JD,Warren A,Graham RA,Dockery P,Cooke ID

    更新日期:1994-07-01 00:00:00

  • Cycle dependency of intrauterine vascular endothelial growth factor levels is correlated with decidualization and corpus luteum function.

    abstract:OBJECTIVE:To determine intrauterine levels of vascular endothelial growth factor (VEGF)-A during the menstrual cycle in the human female and to investigate the impact of decidualization and corpus luteum function. DESIGN:Prospective clinical study. SETTING:Tertiary university center. PATIENT(S):Fifty-four women with...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Licht P,Russu V,Lehmeyer S,Wissentheit T,Siebzehnrübl E,Wildt L

    更新日期:2003-11-01 00:00:00