当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women.

Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women.

Abstract：

OBJECTIVE:To determine whether there is a difference in fibrinolytic compounds in endometriotic tissue, endometrium, peritoneal fluid (PF), and plasma from women with endometriosis and in endometrium and PF from healthy women. DESIGN:Prospective study. SETTING:Two university clinics. PATIENT(S):Regularly menstruating women with and without endometriosis. INTERVENTION(S):Tissue samples, PF, and blood were collected at surgery performed for clinical reasons. MAIN OUTCOME MEASURE(S):The antigen concentrations of plasminogen activators and plasminogen activator inhibitors (PAls) in tissue homogenates, PF, and plasma were assayed by ELISA. RESULT(S):The concentrations of urokinase plasminogen activator (u-PA) and PAI-1 were higher in endometrium from women with endometriosis than in endometrium from controls and even higher in endometriotic tissue than in endometrium from both groups. In PF, the concentration of PAI-2 was higher in women with endometriosis than in controls. CONCLUSION(S):The high concentrations of u-PA and PAI-1 in endometrium from women with endometriosis might facilitate implantation of endometrial cells and the high concentration in endometriotic tissue might contribute to their invasive growth. The inflammatory reaction may contribute to the high concentration of PAI-2.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bruse C,Bergqvist A,Carlström K,Fianu-Jonasson A,Lecander I,Astedt B

doi

10.1016/s0015-0282(98)00285-4

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

821-6

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(98)00285-4

journal_volume

70

pub_type

杂志文章

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