In vitro action of progestogens on sperm migration in human cervical mucus;.

Abstract:

:The presence of progestogens in the cervical mucus suppresses and arrests sperm penetration. Using the Kremer technique, the effects of in vitro released progesterone, d-norgestrel, and cyproterone acetate were studied by inserting silicone rubber threads bearing the respective compounds into capillary tubes containing cervical mucus. Control tubes were fitted with nonmedicated silicone rubber threads. After 24 hours of incubation, the sperm migration test was carried out to evaluate penetration depth, qualitative motility, and proportion of motile forms. Progesterone produced the greatest alterations. Migration was arrested within 30 minutes, the distance reached was consistently less than 2 cm, and sperm were completely immobile at 24 hours. D-norgestrel also exhibited a distinct spermiostatic effect, but it was not as intense as that of progesterone. Cyproterone acetate was practically effective during the first 120 minutes and produced alterations only in the qualitative and proportional motility.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kesserü E,Camacho-Ortega P,Laudahn G,Schopflin G

doi

10.1016/s0015-0282(16)40875-7

keywords:

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

57-61

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)40875-7

journal_volume

26

pub_type

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