Sonographic assessment of endometrial pattern and thickness in patients treated with human menopausal gonadotropins.

Abstract:

OBJECTIVE:To analyze sonographically the endometrium in patients undergoing controlled ovarian stimulation with menotropins in order to determine the significance of endometrial pattern and thickness on pregnancy rate. DESIGN:This is a prospective, nonrandomized study comparing pregnancy rates in patients with hyperechoic homogeneous patterns with those in patients with isoechoic or hypoechoic trilaminar patterns. SETTING:Tertiary infertility center. PATIENTS:All patients receiving menotropin therapy at a tertiary infertility center. INTERVENTIONS:All patients received individualized dosing of hMG starting on cycle day 3. Transvaginal sonography was performed 15 hours before hCG administration and the endometrium was assessed. MAIN OUTCOME MEASURE:Occurrence of pregnancy as determined by serially rising beta-hCG titers and sonographic confirmation. RESULTS:During the study period, 175 patients were evaluated. Thirty-four (19%) patients had a homogeneous endometrium, whereas 141 (81%) patients had a trilaminar pattern. There was 1 pregnancy (2.9%) among women with a homogeneous endometrial pattern and 33 pregnancies (23%) among those with a trilaminar pattern. No significant differences were found in mean E2 level, follicle numbers, parity, and diagnosis between the two groups. CONCLUSION:In patients receiving menotropins, a homogeneous pattern is a bad prognostic sign, regardless of endometrial thickness.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bohrer MK,Hock DL,Rhoads GG,Kemmann E

doi

10.1016/s0015-0282(16)58447-7

subject

Has Abstract

pub_date

1996-08-01 00:00:00

pages

244-7

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)58447-7

journal_volume

66

pub_type

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