Effect of short-term hormone replacement therapy on left ventricular mass and contractile function.

Abstract:

OBJECTIVE:To determine the effect of hormone replacement therapy (HRT) on cardiac structure and function and whether these changes are related to changes in blood volume. DESIGN:Open-label pilot study. SETTING:Academic medical center. PATIENT(S):Eighteen healthy postmenopausal women. INTERVENTION(S):We administered medroxyprogesterone acetate orally, 5 mg/d for 2 months followed by 2 months of oral sequential 17beta-estradiol, 1 mg/d plus medroxyprogesterone acetate, 10 mg/d for the last 12 days of each month. MAIN OUTCOME MEASURE(S):Cardiac output, stroke volume, heart rate, end diastolic volume, end systolic volume, ejection fraction, and left ventricular mass were measured by echocardiography; blood and plasma volumes were measured using 125I-albumin dilution. RESULT(S):Cardiac output, stroke volume, left ventricular mass, end diastolic volume, and ejection fraction increased by 12.8%, 11.7%, 9.4%, 7.2%, and 10.9%, respectively, by 16 weeks. End systolic volume decreased, whereas heart rate was unaffected. There was a significant increase in blood volume (5.2%) and plasma volume (4.8%) from baseline during treatment, which could explain the increased cardiac output but not the increased ejection fraction. CONCLUSION(S):Hormone replacement therapy causes modest but significant increases in cardiac output, ejection fraction, and left ventricular mass. These pilot data suggest a direct myocardial effect of HRT that is preload independent.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Sites CK,Tischler MD,Blackman JA,Niggel J,Fairbank JT,O'Connell M,Ashikaga T

doi

10.1016/s0015-0282(98)00398-7

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

137-43

issue

1

eissn

0015-0282

issn

1556-5653

pii

S0015028298003987

journal_volume

71

pub_type

临床试验,杂志文章
  • Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.

    abstract:OBJECTIVE:To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer. DESIGN:Systematic review of literature. SETTING:Academic Department of Medical Oncology. PATIENT(S):Premenopausal women exposed to adjuvant chemotherapy for breast cancer. MAIN OUTCOME MEA...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2009.02.055

    authors: Cruz MR,Prestes JC,Gimenes DL,Fanelli MF

    更新日期:2010-06-01 00:00:00

  • Gay men choosing parenthood through assisted reproduction: medical and psychosocial considerations.

    abstract:OBJECTIVE:To medically and psychologically assess gay men seeking parenthood through assisted reproduction and to provide guidelines for the assessment. DESIGN:Qualitative observational study. SETTING:Academic medical center. PATIENT(S):Thirty gay males (15 couples) presenting for assisted reproduction using an oocy...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2010.05.053

    authors: Greenfeld DA,Seli E

    更新日期:2011-01-01 00:00:00

  • Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry.

    abstract::In this prospective case-control study, we determined the role of surface-enhanced laser desorption and ionization time-of-flight mass spectrometry in the detection of histologically proven endometriosis. In the plasma of the group with endometriosis, there were 20 different protein peaks, and the classifier showed a ...

    journal_title:Fertility and sterility

    pub_type: 信件

    doi:10.1016/j.fertnstert.2006.08.095

    authors: Liu H,Lang J,Zhou Q,Shan D,Li Q

    更新日期:2007-04-01 00:00:00

  • A case of a methotrexate-resistant ectopic pregnancy in which dactinomycin was effective as a second-line chemotherapy.

    abstract:OBJECTIVE:To report a case of a methotrexate (MTX)-resistant heterotopic interstitial pregnancy in which dactinomycin was necessary as a second-line chemotherapy. DESIGN:Case report. SETTING:Medical college-affiliated hospital. PATIENT(S):A 39-year-old woman with vaginal bleeding after the transfer of two thawed 8-c...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.10.003

    authors: Fujioka S,Yamashita Y,Kawabe S,Kamegai H,Terai Y,Ohmichi M

    更新日期:2009-03-01 00:00:00

  • Collagenolytic enzyme activity in human ovary: an ovulatory enzyme system.

    abstract::Collagenolytic enzyme activities presumed to play an important role in ovulation were investigated in the human follicular apex, base, and granulosa cell layer throughout the ovarian cycle. Those analyzed were human ovarian collagenase, 2,4-dinitrophenyl-Pro-Gln-Gly-Ile-Ala-Gly-Gln-D-Arg-OH peptidase, N-carbobenzoxy-G...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)45920-0

    authors: Fukumoto M,Yajima Y,Okamura H,Midorikawa O

    更新日期:1981-12-01 00:00:00

  • The endocrinology of varicoceles.

    abstract::There is good evidence of an associated abnormality in testicular hormone production and spermatogenesis in some men with varicoceles. This abnormality can be demonstrated with dynamic tests of the hypothalamic-pituitary-testicular axis and by measuring seminal plasma androgen levels. A high proportion of oligozoosper...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/s0015-0282(16)59700-3

    authors: Hudson RW

    更新日期:1988-02-01 00:00:00

  • Conservative medical and surgical management of interstitial ectopic pregnancy.

    abstract:OBJECTIVE:To review the definition and diagnosis of interstitial and heterotopic interstitial pregnancy and to evaluate the conservative management of these conditions. DESIGN:A MEDLINE computer search was used to identify relevant studies. The mean values for the duration of amenorrhea, serum beta-hCG level, size of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/s0015-0282(99)00242-3

    authors: Lau S,Tulandi T

    更新日期:1999-08-01 00:00:00

  • Adhesion reformation after reproductive surgery by videolaseroscopy.

    abstract::After initial videolaseroscopy for the treatment of endometriosis-associated infertility, 157 patients underwent a second-look laparoscopy to evaluate and treat recurrence of disease and/or adhesions. The patients were divided into two groups. Group 1 consisted of 135 patients who underwent second-look laparoscopy for...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)53576-6

    authors: Nezhat CR,Nezhat FR,Metzger DA,Luciano AA

    更新日期:1990-06-01 00:00:00

  • Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer.

    abstract:OBJECTIVE:To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN:Retrospective cohort study. SETTING:University-based infertility center, January 1998 to June 2006. PATIENT(S):Two hundred eighteen IVF pregnancie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2010.05.049

    authors: Kansal Kalra S,Ratcliffe SJ,Milman L,Gracia CR,Coutifaris C,Barnhart KT

    更新日期:2011-02-01 00:00:00

  • Low antimüllerian hormone (AMH) is associated with decreased live birth after in vitro fertilization when follicle-stimulating hormone and AMH are discordant.

    abstract:OBJECTIVE:To evaluate which factor, AMH or FSH, was superior in predicting live birth after assisted reproductive technologies (ART) when the tests are discordant, using data from the Society for Assisted Reproductive Technology Clinical Outcomes Reporting System database. DESIGN:Retrospective cohort. SETTING:Clinic-...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2019.03.022

    authors: Ligon S,Lustik M,Levy G,Pier B

    更新日期:2019-07-01 00:00:00

  • Cutoff value of human chorionic gonadotropin in relation to the number of methotrexate cycles in the successful treatment of ectopic pregnancy.

    abstract:OBJECTIVE:To assign cutoff values for human chorionic gonadotropin (beta-hCG) in pretreatment and after one methotrexate (MTX) cycle and determine its correspondence to the number of MTX cycles in successfully treated ectopic pregnancy. DESIGN:Retrospective study. SETTING:Polish university hospital. PATIENT(S):68 wo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.07.1775

    authors: Nowak-Markwitz E,Michalak M,Olejnik M,Spaczynski M

    更新日期:2009-10-01 00:00:00

  • High rate of mixoploidy among human blastocysts cultured in vitro.

    abstract:OBJECTIVE:To determine the incidence and type of mixoploidy in human blastocysts produced in vitro. DESIGN:A laboratory study of spare blastocysts from an IVF program. SETTING:University hospital laboratory. PATIENT(S):Thirty-nine couples undergoing IVF or intracytoplasmic sperm injection. INTERVENTION(S):A total o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(02)04393-5

    authors: Bielanska M,Tan SL,Ao A

    更新日期:2002-12-01 00:00:00

  • NR5A1 (SF-1) gene variants in a group of 26 young women with XX primary ovarian insufficiency.

    abstract:OBJECTIVE:To determine whether NR5A1 (SF-1) variants are a cause of primary ovarian insufficiency (POI) in 26 young women with similar genetic background. DESIGN:Genetic and functional mutation study. SETTING:University hospitals. PATIENT(S):Genetic analysis of the NR5A1 gene in 26 XX girls with POI. INTERVENTION(S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2012.10.026

    authors: Philibert P,Paris F,Lakhal B,Audran F,Gaspari L,Saâd A,Christin-Maître S,Bouchard P,Sultan C

    更新日期:2013-02-01 00:00:00

  • Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study.

    abstract:OBJECTIVE:To assess the potential effect of bisphenol A (BPA), triclosan (TCS), and phthalates on women's fecundity, as measured by time to pregnancy (TTP). DESIGN:Pregnancy-based retrospective TTP study. SETTING:Not applicable. PATIENT(S):A total of 2,001 women during the first trimester of pregnancy recruited betw...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2015.01.005

    authors: Vélez MP,Arbuckle TE,Fraser WD

    更新日期:2015-04-01 00:00:00

  • Comparison of two colloidal silica-based sperm separation media with a non-silica-based medium.

    abstract:OBJECTIVE:To study and compare the effects of three sperm separation media, two silica-based (Percoll; Pharmacia Biotech AB, Uppsala, Sweden, and Isolate; Irvine Scientific, Santa Ana, CA) and one non-silica-based (Ixaprep; Medicult, Copenhagen, Denmark), on the recovery of progressive motile sperm, the percentage of s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(99)00375-1

    authors: Makkar G,Ng HY,Yeung SB,Ho PC

    更新日期:1999-11-01 00:00:00

  • Recommended practices for the management of embryology, andrology, and endocrinology laboratories: a committee opinion.

    abstract::This document provides a general overview for physicians of the qualities and conditions necessary for good management practices within the endocrinology, andrology, and embryology laboratories in the United States. It is intended as an addendum to previously published guidelines that further detail these responsibili...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,实务指引,评审

    doi:10.1016/j.fertnstert.2014.06.036

    authors: Practice Committee of the American Society for Reproductive Medicine.,Practice Committee of the Society for Assisted Reproductive Technology.,Practice Committee of the Society of Reproductive Biologists and Technologists.

    更新日期:2014-10-01 00:00:00

  • Endometriosis entrapment of the obturator nerve after previous cervical cancer surgery.

    abstract::A 26-year-old patient underwent pelvic lymphadenectomy and trachelectomy because of cervical cancer stage IB. Later she developed symptoms from obturator nerve entrapment. Examinations could not reveal metastatic cancer disease, but endometriosis surrounding the obturator nerve was discovered. Laparoscopic removal of ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2008.03.024

    authors: Langebrekke A,Qvigstad E

    更新日期:2009-02-01 00:00:00

  • Discovery of germ cell-specific transcripts by expressed sequence tag database analysis.

    abstract:OBJECTIVE:To identify transcripts whose expression is restricted to germ cells. DESIGN:Expressed sequence tags (ESTs) from unfertilized egg libraries were utilized to perform in silico subtraction and identify germ cell-specific transcripts. SETTING:Baylor College of Medicine, Houston, Texas. ANIMAL(S):C57BL/6J/129S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(01)01966-5

    authors: Rajkovic A,Yan M S C,Klysik M,Matzuk M

    更新日期:2001-09-01 00:00:00

  • Identification of antibody-laden sperm by cytofluorometry.

    abstract::A direct assay for measuring sperm-associated immunoglobulin G (IgG) and an indirect assay for measuring IgG plasma antisperm antibodies were devised utilizing fluorescein-labeled antihuman IgG and a fluorescein-activated flow cytometer. The method singularly analyzed Ig attached to the surface of sperm because sperm ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)48146-x

    authors: Haas GG Jr,Cunningham ME

    更新日期:1984-10-01 00:00:00

  • Analysis of FOXP3 polymorphisms in infertile women with and without endometriosis.

    abstract:OBJECTIVE:To evaluate FOXP3 polymorphisms (rs3761549, rs3761548, rs2232368, rs2232366, and rs2280883) in a group of infertile women with and without endometriosis and controls. DESIGN:Case control study. SETTING:Human Reproduction Outpatient Clinic of Faculdade de Medicina do ABC. PATIENT(S):The study groups were 17...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2011.03.033

    authors: André GM,Barbosa CP,Teles JS,Vilarino FL,Christofolini DM,Bianco B

    更新日期:2011-06-01 00:00:00

  • Effects of low concentrations of nitric oxide on the zona pellucida binding ability of human spermatozoa.

    abstract:OBJECTIVE:To investigate the direct effects of sodium nitroprusside, a nitric oxide donor, on the fertilizing ability of human spermatozoa in vitro. DESIGN:Prospective, controlled in vitro study. SETTING:IVF Unit, Medical College Hospital. PATIENT(S):Women undergoing conventional IVF. INTERVENTION(S):Human spermato...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(97)00537-2

    authors: Sengoku K,Tamate K,Yoshida T,Takaoka Y,Miyamoto T,Ishikawa M

    更新日期:1998-03-01 00:00:00

  • Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients.

    abstract:OBJECTIVE:To investigate c-fos and matrix metalloproteinase-9 (MMP-9) expression in the endometrium from women with or without endometriosis throughout the menstrual cycle, and to explore the correlation of c-fos expression with MMP-9 expression and 17beta-E(2) levels in serum. DESIGN:Molecular studies in human tissue...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2007.07.1386

    authors: Pan H,Sheng JZ,Tang L,Zhu R,Zhou TH,Huang HF

    更新日期:2008-10-01 00:00:00

  • Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Mass...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2006.11.109

    authors: Evans WS,Taylor AE,Boyd DG,Johnson ML,Matt DW,Jimenez Y,Nestler JE

    更新日期:2007-07-01 00:00:00

  • Subcutaneously administered Repronex in female patients undergoing in vitro fertilization is as effective and well tolerated as intramuscular menotropin treatment. Repronex SC, IVF Study Group.

    abstract:OBJECTIVE:To determine the efficacy and safety of Repronex SC as compared with Repronex IM and Pergonal IM in patients undergoing IVF. DESIGN:Open-label, randomized, parallel-group, multicenter study. SETTING:Fifteen academic and private fertility clinics with IVF experience. PATIENT(S):Premenopausal women with regu...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0015-0282(00)00605-1

    authors: Gocial B,Keye WR,Fein SH,Nardi RV

    更新日期:2000-07-01 00:00:00

  • Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.

    abstract:OBJECTIVE:To evaluate the association between fetal and maternal catechol-O-methyltransferase (COMT) Val158Met and methyl tetrahydrofolate reductase (MTHFR) C677T functional polymorphisms and preeclampsia, examining its influence on placental COMT and in maternal 2-methoxyestradiol (2-ME) plasma levels. DESIGN:Prospec...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2015.09.019

    authors: Pertegal M,Fenoy FJ,Hernández M,Mendiola J,Delgado JL,Bonacasa B,Corno A,López B,Bosch V,Hernández I

    更新日期:2016-01-01 00:00:00

  • Assessing new terminal body and facial hair growth during pregnancy: toward developing a simplified visual scoring system for hirsutism.

    abstract:OBJECTIVE:To study the distribution and progression of terminal hair growth in pregnant women and to determine the feasibility of a simplified scoring system for assessing hirsutism. DESIGN:Prospective follow-up observational study. SETTING:Academic hospital. PATIENT(S):A total of 115 pregnant women (discovery cohor...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/j.fertnstert.2015.10.036

    authors: Yang Y,Han Y,Wang W,Du T,Li Y,Zhang J,Yang D,Zhao X

    更新日期:2016-02-01 00:00:00

  • Microsurgical tubocornual anastomosis for occlusive cornual disease: reproducible results without the need for tubouterine implantation.

    abstract::Microsurgical tubocornual anastomosis (TCA) and tubouterine implantation are the two primary operations used to treat proximal tubal occlusion (PTO). Tubouterine implantation usually has been reserved for cases of PTO in which the occlusion spans the entire intramural tubal segment. Yet TCA has proven to be more likel...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)49630-5

    authors: McComb P

    更新日期:1986-10-01 00:00:00

  • Assessment of sperm using mRNA microarray technology.

    abstract::The aim of this work is to review the need for new diagnostic tools for sperm, the relevance of sperm mRNA in reproductive success, and the potential of a state-of-the-art microarray-based diagnostic tool for improving reproductive results. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审

    doi:10.1016/j.fertnstert.2013.02.006

    authors: Garrido N,García-Herrero S,Meseguer M

    更新日期:2013-03-15 00:00:00

  • Creation of a neovagina following Williams vaginoplasty and the Creatsas modification in 111 patients with Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract:OBJECTIVE:Evaluation of the Creatsas modification of Williams vaginoplasty for the creation of neovagina in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome). DESIGN:Record of perioperative and postoperative results and complications. Follow-up evaluations of patients yearly after the operation. S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(01)02836-9

    authors: Creatsas G,Deligeoroglou E,Makrakis E,Kontoravdis A,Papadimitriou L

    更新日期:2001-11-01 00:00:00

  • Hyperprolactinemia in primary adrenocortical insufficiency.

    abstract::A patient with primary adrenocortical deficiency presented with galactorrhea and hyperprolactinemia, in addition to the usual characteristic symptoms of adrenal insufficiency. With steroid replacement therapy, PRL levels returned to normal, with resumption of normal ovulatory cycles; and the patient became pregnant. P...

    journal_title:Fertility and sterility

    pub_type: 杂志文章

    doi:10.1016/s0015-0282(16)48872-2

    authors: Kelver ME,Nagamani M

    更新日期:1985-09-01 00:00:00