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Follicle-stimulating hormone or human menopausal gonadotropin for ovarian stimulation in in vitro fertilization cycles: a meta-analysis.

Abstract：

OBJECTIVE:To reanalyze the results of using FSH alone and hMG during IVF treatment, taking into account the different protocols of administration of superactive GnRH agonist analogs. DESIGN:Meta-analysis. SETTING:The London Women's Clinic. PATIENT(S):Women undergoing IVF treatment. INTERVENTION(S):A meta-analysis of published randomized controlled trials from 1985 to 1999 of the use of FSH versus hMG for ovarian stimulation during IVF treatment. The common Peto odds ratio was calculated with use of a fixed effect model. The overall log odds ratio was estimated after demonstrating the consistency or homogeneity of the study results. MAIN OUTCOME MEASURE(S):Clinical pregnancy rate per cycle of IVF. RESULT(S):The results suggested that in the "long and short GnRH agonists protocol" of IVF, FSH, and hMG were equally effective in achieving ovarian stimulation, and there were no differences in the clinical pregnancy rates per cycle of IVF. However, in protocols where no pituitary desensitization was used, FSH alone was more efficacious. CONCLUSION(S):The optimum choice of gonadotropin preparation for ovarian stimulation during IVF treatment is influenced by the regimen of pituitary desensitization used. The optimum gonadotropin to be used when GnRH antagonists are used has yet to be determined.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Agrawal R,Holmes J,Jacobs HS

doi

10.1016/s0015-0282(99)00519-1

keywords:

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

338-43

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(99)00519-1

journal_volume

73

pub_type

杂志文章,meta分析

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