Long-term intranasal luteinizing hormone-releasing hormone agonist treatment for contraception in women.

Abstract:

:Fifty-one female volunteers used a superactive stimulatory luteinizing hormone-releasing hormone (LH-RH) analog for suppression of ovulation for 3 to 12 months. The potent LH-RH agonist D-Ser(TBU)6-EA10-LH-RH was administered intranasally once daily in a dose of 400 or 600 micrograms. No pregnancies occurred during the 283 treatment months. Severe bleeding disturbances were not observed during the long-term treatment. No signs of hyperplastic changes were found in endometrial biopsies. There were no serious side effects. Ovulation promptly returned after cessation of treatment even in women with amenorrhea during treatment periods of 1 year or more. Thus, long-term LH-RH agonist treatment proved to be a safe, effective, and rapidly reversible new method for peptide contraception.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bergquist C,Nillius SJ,Wide L

subject

Has Abstract

pub_date

1982-08-01 00:00:00

pages

190-3

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)46458-7

journal_volume

38

pub_type

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