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Effects of letrozole on superovulation with gonadotropins in women undergoing intrauterine insemination.

Abstract：

OBJECTIVE:To investigate the effects of letrozole in patients undergoing superovulation with gonadotropins and IUI. DESIGN:Retrospective analysis. SETTING:Academic teaching hospital. PATIENT(S):Women younger than 40 years of age with patent fallopian tubes and infertility of more than 1 year in duration who were undergoing IUI and gonadotropin therapy. INTERVENTION(S):Gonadotropins alone administered from day 3 or a combination of letrozole, 5 mg/d on day 3 to 7, and gonadotropins starting on day 5 of the menstrual cycle. Ultrasonography was performed before initiation of treatment, on day 9 of menstrual cycle, and as required thereafter until the dominant follicle reached 18 mm in diameter. Ovulation was triggered with 10,000 IU of hCG, and IUI was performed 24 and 48 hours later. MAIN OUTCOME MEASURE(S):Gonadotropin requirements, endometrial thickness, number of follicles, and pregnancy rate. RESULT(S):All 205 IUI treatment cycles conducted from March 2001 to March 2002 were included. Gonadotropins alone were used in 145 cycles and combination therapy was used in 60 cycles. Patients cotreated with letrozole required fewer gonadotropin administrations (median difference, 300 IU [95% confidence interval (CI), 225-375 IU]), developed more follicles larger than 14 mm (median difference, 1 follicle [95% CI, 1-2 follicles), and had a thinner endometrium (median difference, 1 mm [95% CI, 0.4-1.6 mm]). The pregnancy rate did not differ between patients using gonadotropin alone and those using gonadotropin plus letrozole (20.9% vs. 21.6%). CONCLUSION(S):The addition of letrozole to gonadotropins decreases gonadotropin requirements, increases the number of pre-ovulatory follicles and decreases endometrial thickness, without a negative effect on pregnancy rates.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Healey S,Tan SL,Tulandi T,Biljan MM

doi

10.1016/j.fertnstert.2003.03.001

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1325-9

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015028203022325

journal_volume

80

pub_type

杂志文章

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