OCT4 gonadal gene expression related to the presence of Y-chromosome sequences in Turner syndrome.

Abstract:

:To show that in the dysgenetic gonads of 104 Turner syndrome patients no significant difference was found regarding the expression of the genes DAX1, FOG2, GATA4, OCT4, SF1, SRY, TSPY, WT1, and STRA8 compared with controls, except for genes OCT4, SRY, and TSPY in both gonads of a patient whose chromosomal constitution was 45,X/45,X,add(15)(p11). The expression analysis of genes OCT4, SRY, and TSPY in the dysgenetic gonads of Turner syndrome patients may allow introducing modifications in the microenvironment that could contributed to a malignant transformation process.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bianco B,Oliveira KC,Guedes AD,Barbosa CP,Lipay MV,Verreschi IT

doi

10.1016/j.fertnstert.2010.02.036

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

2347-9

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(10)00315-8

journal_volume

94

pub_type

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