Studies on nonoxynol-9. III. Effect on fibroblasts and spermatozoa.

Abstract:

:Seven nonionic detergents of the Igepal CO series differing in molecular size and including nonoxynol-9 and a representative anionic (SDS) and cationic (Cepacol) detergent were tested as to their relative cytotoxicity. The biologic effects of these detergents on human W1--38 fibroblasts (DNA and glycosaminoglycans synthesis) and on the motility of human spermatozoa were studied. The relative order of cytotoxicities for both fibroblasts and spermatozoa was cationic greater than nonionic greater than anionic. The concentration of nonoxynol-9-inhibiting fibroblast activity was approximately 30 times less than the amount needed to immobilize spermatozoa. It is concluded that CO-630, used as a source of nonoxynol-9, is the most effective polymer to inhibit spermatozoa and also fibroblasts.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Chvapil M,Ulreich JB,O'Dea K,Betts K,Droegemueller W

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

521-5

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)44718-7

journal_volume

33

pub_type

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