Abstract:
OBJECTIVE:To quantify nerve fibers and mast cells in human ovaries at different functional stages. DESIGN:Retrospective study. SETTING:Research laboratory of the university. SPECIMEN(S): 8 human ovaries in the follicular (cyclic) phase, 7 polycystic ovaries, and postmenopausal ovaries with (n=5) or without (n=7) hyperthecosis. MAIN OUTCOME MEASURE(S):Single- and double immunohistology for the S100 antigen in glial cells of autonomic nerve fibers, for chymase and tryptase in mast cells, and for the common leukocyte antigen on leukocytes. Histometric evaluation was also performed. INTERVENTION(S):None. RESULT(S):Polycystic ovaries contained significantly more S100-positive nerve fibers in the corticomedullary region than did cyclic ovaries (mean +/- SD per 2-mm(2) area, 476 +/- 136 and 224 +/- 133; P<.01). Postmenopausal ovaries with or without hyperthecosis had the highest density of nerve fibers. In cyclic and polycystic ovaries, more tryptase-positive mast cells than chymase-positive mast cells were found in the interstitial cortex and the medulla. In cyclic ovaries, areas with a moderate density of nerve fibers contained many mast cells. Hence, with increasing nerve fiber density in polycystic ovaries, the number of mast cells decreased strikingly compared with cyclic ovaries (p<.001). Almost no mast cells were seen in postmenopausal ovaries with and without hyperthecosis. The number of leukocyte antigen-positive leukocytes was similar in all groups. CONCLUSION(S):The high density of nerve fibers in polycystic and postmenopausal ovaries, together with a conspicuous decrease in mast cells, indicates altered neuroimmune communication.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Heider U,Pedal I,Spanel-Borowski Kdoi
10.1016/s0015-0282(01)01805-2keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
1141-7issue
6eissn
0015-0282issn
1556-5653pii
S0015-0282(01)01805-2journal_volume
75pub_type
杂志文章abstract:OBJECTIVE:To determine if estrogen ameliorates hot flashes by raising the core body temperature sweating threshold, by reducing core body temperature fluctuations, and/or by reducing sympathetic activation (as measured by plasma 3-methoxy-4-hydroxyphenylglycol). DESIGN:Laboratory physiological study. SETTING:Universi...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(01)03009-6
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To determine expression of integrins α₁, α₄, and αVβ₃ in the glandular and luminal epithelium, stroma, and cells in the blood vessel walls of the endometrium from women with recurrent implantation failure (RIF) and to determine if they are of prognostic value in determining pregnancy outcome. DESIGN:Prospect...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2013.05.007
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To determine whether serum interleukin (IL)-8 concentration can be measured in patients with ovarian endometrioma and whether this measurement is a useful tool in diagnosing this disease. DESIGN:A controlled clinical study and an in vitro study. SETTING:Department of Obstetrics and Gynecology, Tottori Unive...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.07.1355
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To report the restoration of ovarian function and pregnancy in a woman after bilateral oophorectomy for benign disease after autotransplantation of cryopreserved ovarian cortex. DESIGN:Case report. SETTING:Gynecology research unit in a university hospital. PATIENT(S):A 28-year-old woman who underwent bilat...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.05.017
更新日期:2012-09-01 00:00:00
abstract::Twenty-seven patients underwent ultrasonographic and clinical monitoring of a spontaneous cycle so that human chorionic gonadotropin administration could be timed in an attempt to schedule the screening laparoscopy at the optimal time for oocyte aspiration. Inadequate ovarian access was encountered in only 2 of 26 lap...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46871-8
更新日期:1983-03-01 00:00:00
abstract::In overweight women with polycystic ovary syndrome, weight loss improves arterial compliance and postprandial lipidemia. Modifying dietary carbohydrate or protein in weight loss provided similar improvements in arterial compliance and postprandial lipidemia. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2010.02.057
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of estrogen and progestogen on the resistance to blood flow in the uterine arteries of Turner's syndrome patients. DESIGN:Prospective clinical study. SETTING:A tertiary infertility clinic. PATIENTS:Five Turner's syndrome patients, six patients who had surgical castration, and five...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57968-0
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To confirm successful implantation of IVF, cryopreserved human embryos after assisted hatching with acidic Tyrode's solution. DESIGN:Case report. SETTING:In vitro fertilization-ET facility of a university-based practice. PATIENT:A 28-year-old female with nonoperable bilateral tubal occlusion and > 1 1/2 ye...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57376-2
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:To assess the predictive value of endocrine gland-derived vascular endothelial growth factor (EG-VEGF) concentrations in follicular fluid (FF) and serum for ovarian hyperstimulation syndrome (OHSS) in patients undergoing controlled ovarian hyperstimulation. DESIGN:Retrospective, case-control study. SETTING:...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.09.044
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To determine the concentrations of angiopoietin 1 (ANGPT1) and ANGPT2 in individual human preovulatory follicles in relation to their diameter or volume to clarify the role of these molecules in folliculogenesis. DESIGN:Prospective study. SETTING:Research laboratory at Kansai Medical University, Osaka, Japa...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/j.fertnstert.2011.09.031
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes mellitus (T2DM) in Korean women. DESIGN:Longitudinal case-control study. SETTING:Not applicable. PATIENT(S):PCOS patients aged 15 to 44 years (n = 1,136) and control individuals (n = 5,675), matched 1:5 by age grou...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.12.018
更新日期:2021-01-25 00:00:00
abstract:OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.01.100
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic accuracy of two methods of assessment of tubal patency, viz, hysterosalpingography (HSG) and laparoscopic hydrotubation. DESIGN:One hundred four infertile women who were investigated with both HSG and laparoscopy in King Khalid University Hospital were selected for the study. Comple...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)57540-2
更新日期:1995-05-01 00:00:00
abstract::For determination of how exposure of the monkey follicle to the preovulatory luteinizing hormone (LH)/follicle-stimulating hormone (FSH) surge alters its responsiveness to FSH in terms of estrogen and progesterone secretory ability, monkey thecal tissue and granulosa cells were harvested prior to and during the midcyc...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48087-8
更新日期:1984-09-01 00:00:00
abstract::A prospective longitudinal and standardized study is presented, dealing with ultrasonographic and hormonal characteristics of the luteinized unruptured follicle (LUF) syndrome. Among 600 cycles monitored in 270 infertility patients, 40 cycles in 27 patients showed no evidence of follicle rupture, in spite of signs of ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)48494-3
更新日期:1985-04-01 00:00:00
abstract::Chromosomal abnormalities, sperm DNA damage, zona hardening, inadequate culture conditions, and suboptimal embryo development all play a significant role in the etiology of recurrent implantation failure. Evidence suggests that preimplantation genetic screening does not increase implantation or live birth rates. Compa...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2012.02.029
更新日期:2012-05-01 00:00:00
abstract::D-group chromosome translocations have been associated in isolated cases with infertility in males. In this study, we demonstrated the effect of a translocated D-group chromosome on spermatogenesis as it had segregated among three male members of one family. Although the father, who carried the translocation, was obvi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)41651-1
更新日期:1976-02-01 00:00:00
abstract:OBJECTIVE:The response to subcutaneous (SC) gonadotropin replacement therapy, using human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) or hCG alone, was evaluated in male hypothalamic hypogonadism. DESIGN:Sixteen patients with hypothalamic hypogonadism were treated with gonadotropins for induct...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)54493-8
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 15-y...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.04.028
更新日期:2011-07-01 00:00:00
abstract::This document discusses the evaluation and management of varicoceles in the male partners of infertile couples, and presents the controversies and recommendations regarding this condition. This document replaces the ASRM Practice Committee document titled "Report on Varicocele and Infertility," last published in 2008,...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引
doi:10.1016/j.fertnstert.2014.10.007
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To compare the ability of peripheral blood monocytes (PBM) and peritoneal macrophages (PM) to mediate the in vitro cytolysis of endometrial cells from eutopic and ectopic endometrium in women with endometriosis. DESIGN:Prospective study of immune function. SETTING:Institute for the Study and Treatment of En...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00062-4
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of microdeletions of the long arm of chromosome Y within the AZFa, AZFb, and AZFc subregions in patients with idiopathic azoospermia, and then correlate the microdeletions with clinical phenotypes to determine the most important subregion for screening. DESIGN:Controlled clinical ...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(01)01955-0
更新日期:2001-09-01 00:00:00
abstract::To explore the abnormal steroidogenesis in subjects with primary testicular failure, we measured serum levels of testosterone (T) and its precursors androstenedione (delta 4A) and 17-hydroxyprogesterone (17-OHP) in the basal state and after stimulation by human chorionic gonadotropin (hCG) for 4 hours (acute reserve) ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46401-0
更新日期:1982-07-01 00:00:00
abstract::A couple may be considered to have fertility problems if they have been trying to conceive for over 1 year with no success. Worldwide, the inability to have children affects 10% to 15% of all couples. Subfertility can be divided into either male or female factor, or both partners can be affected. However, for some cou...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2018.05.028
更新日期:2018-09-01 00:00:00
abstract::One hundred and twenty rats were divided into six groups and laparotomized. In three of the groups the cecum was left intact. In one of these groups the cecum was only lifted up through the abdominal incision and then replaced in the abdominal cavity. In another group the intact cecum was bathed with a certain amount ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43584-3
更新日期:1978-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the size of ovarian damage caused by ovarian drilling in polycystic ovary syndrome, the amount of inflicted damage was assessed for the most frequently used ovarian drilling techniques. DESIGN:Experimental prospective design. SETTING:University clinic. PATIENT(S):Six fresh bovine ovaries per te...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.10.046
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To study concordance rates of cryptorchidism (undescended testis) in pairs of boys with varying family structure, to evaluate the risk contribution from the intrauterine environment and genetic factors. DESIGN:Population based study of 1,024,500 Danish boys born from January 1, 1973 to December 31, 2004. Cla...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.09.041
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To study the interobserver reproducibility of our new ultrasonographic mapping system to define the type and extension of uterine adenomyosis. DESIGN:Interobserver study involving two observers with different medical backgrounds and gynecological ultrasound experience. SETTING:University hospital. PATIENTS...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2018.06.031
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. DESIGN:Prospective cohort study. SETTING:General community. PATIENT(S):A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.008
更新日期:2012-12-01 00:00:00
abstract::The authors studied the role of follicle-stimulating hormone (FSH) in luteal steroidogenesis by replacing gonadotropin-releasing hormone (GnRH) infusion with pure FSH 48 hours after ovulation in two hypogonadotropic patients. Plasma progesterone (P) and estradiol (E2) decreased after FSH administration. Human luteal c...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60611-8
更新日期:1989-04-01 00:00:00