Plasminogen activator inhibitor 1 and miscarriage after metformin treatment and laparoscopic ovarian drilling in patients with polycystic ovary syndrome.


:In women with polycystic ovary syndrome, metformin administration, not laparoscopic ovarian drilling, reduces plasminogen activator inhibitor 1 (PAI-1) activity. The lack of a decrease in PAI-1 activity is related to a high risk for miscarriage.


Fertil Steril


Fertility and sterility


Palomba S,Orio F Jr,Falbo A,Russo T,Tolino A,Zullo F





Has Abstract


2005-09-01 00:00:00














  • A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio.

    abstract:OBJECTIVE:To evaluate whether some ultrasound parameters of ovarian morphology can discriminate between control women and patients with polycystic ovary syndrome (PCOS). DESIGN:Retrospective data analysis. SETTING:Volunteers women in an academic research environment. PATIENT(S):Eighty amenorrheic or oligomenorrheic ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fulghesu AM,Ciampelli M,Belosi C,Apa R,Pavone V,Lanzone A

    更新日期:2001-08-01 00:00:00

  • Characterization and mutation analysis of the human formin-2 (FMN2) gene in women with unexplained infertility.

    abstract:OBJECTIVE:Formin-2 (Fmn2) mutant mice produce oocytes with meiosis I arrest. Our aim was to describe the human FORMIN-2 (FMN2) gene and to identify DNA sequence polymorphisms in patients with unexplained infertility and multiple failed IVF cycles. DESIGN:Institutional review board-approved observational case-control s...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ryley DA,Wu HH,Leader B,Zimon A,Reindollar RH,Gray MR

    更新日期:2005-05-01 00:00:00

  • The expression of CD9 in the peri-implantation mouse uterus is upregulated in an ovarian steroid hormone-dependent manner.

    abstract:OBJECTIVE:To examine the spatiotemporal expression of CD9 protein in the peri-implantation mouse uterus as well as the effects of ovarian steroid hormones on CD9. DESIGN:Experimental animal study. SETTING:Reproductive biological center of Chinese Academy of Sciences. ANIMAL(S):Female Kunming white strain mice (6-8 w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Weimin L,Yujing C,Jing L,Zeng H,Ping Z,Enkui D

    更新日期:2007-03-01 00:00:00

  • Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome.

    abstract:OBJECTIVE:To study the association between two single-nucleotide polymorphisms (SNPs) variants (rs2241766 and rs1501299) of the adiponectin gene (ADIPOQ) and polycystic ovary syndrome (PCOS) in PCOS family trios. DESIGN:Family-based study. SETTING:University hospital. PATIENT(S):A total of 224 unrelated PCOS proband...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhang W,Wei D,Sun X,Li J,Yu X,Shi Y,Chen ZJ

    更新日期:2014-05-01 00:00:00

  • Society for assisted reproductive technology position statement on donor suitability of recipients of smallpox vaccine (vaccinia virus).

    abstract::Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that assisted reproductive technology (ART) practitioners consider deferring donors who have recently received smallpox vaccine or contracted symptomatic vaccinia virus in...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Practice Committee of the American Society for Reproductive Medicine.,Society for Assisted Reproductive Technology.

    更新日期:2004-04-01 00:00:00

  • Child with Beckwith-Wiedemann syndrome born after assisted reproductive techniques to an human immunodeficiency virus serodiscordant couple.

    abstract:OBJECTIVE:To report a child with Beckwith-Wiedemann syndrome (BWS) born after assisted reproductive technology (ART) to an HIV serodiscordant couple. DESIGN:Case report. SETTING:Academic medical center. PATIENT(S):A child with BWS born after ART to an HIV serodiscordant couple. INTERVENTION(S):Assisted reproductive...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kuentz P,Bailly A,Faure AC,Blagosklonov O,Amiot C,Bresson JL,Roux C

    更新日期:2011-07-01 00:00:00

  • Pelvic adhesions following microsurgical and macrosurgical wedge resection of the ovaries.

    abstract::The incidence of postoperative adhesion formation following microsurgical and macrosurgical ovarian wedge resection was contrasted in 10 adult female rhesus monkeys. Bilateral wedge resection was performed on day 10 of the luteal phase using microsurgical technique on one ovary and macrosurgical technique contralatera...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Eddy CA,Asch RH,Balmaceda JP

    更新日期:1980-05-01 00:00:00

  • The discriminatory human chorionic gonadotropin zone for endovaginal sonography: a prospective, randomized study.

    abstract:OBJECTIVE:To determine the probability of detecting the gestational sac of a normal intrauterine pregnancy by vaginal ultrasound at different gestational ages and serum hCG concentrations. DESIGN:Prospective, randomized study. SETTING:Pregnant human volunteers in a university-based clinical research environment. PAT...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kadar N,Bohrer M,Kemmann E,Shelden R

    更新日期:1994-06-01 00:00:00

  • The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids.

    abstract::The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Barão MA,Oliveira E,Gomes MT,da Silva ID,Sartori MG,Girão MJ,Castro Rde A

    更新日期:2010-12-01 00:00:00

  • Epigenetic regulation of an adverse metabolic phenotype in polycystic ovary syndrome: the impact of the leukocyte methylation of PPARGC1A promoter.

    abstract:OBJECTIVE:To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycystic ovary syndrome (PCOS) and analyze the relationship between these indices and metabolic risk for women with PCOS. DESIGN:Cross-sectional study. SETTING:University hospital. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Zhao H,Zhao Y,Ren Y,Li M,Li T,Li R,Yu Y,Qiao J

    更新日期:2017-02-01 00:00:00

  • Induction of the human sperm acrosome reaction by human oocytes.

    abstract::The acrosome reaction of human spermatozoa incubated in the presence or absence of vested human oocytes was investigated. All gametes were obtained from human in vitro fertilization (IVF) cases. Spermatozoa were collected after incubation in insemination medium only and following removal of the oocytes from inseminati...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: De Jonge CJ,Rawlins RG,Zaneveld LJ

    更新日期:1988-12-01 00:00:00

  • The role of varicocele repair in nonobstructive azoospermia must be evaluated with controlled trials rather than observational studies.

    abstract::Certainly, varicoceles can have a substantive effect on sperm production in infertile males. In addition, varicocele repair may optimize sperm production. However, additional studies and evaluation of the role of varicocele repair in men with this condition (nonobstructive azoospermia) are warranted. ...

    journal_title:Fertility and sterility

    pub_type: 评论,杂志文章


    authors: Schlegel PN

    更新日期:2011-02-01 00:00:00

  • Previous ectopic pregnancy as a predictor of failure of systemic methotrexate therapy.

    abstract:OBJECTIVE:To investigate whether a history of previous ectopic pregnancy is an independent risk factor for failure of methotrexate therapy in subsequent ectopic pregnancies and whether the previous treatment method influenced failure. SETTING:Inner-city teaching hospital. DESIGN:Retrospective case review. PATIENT(S)...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lipscomb GH,Givens VA,Meyer NL,Bran D

    更新日期:2004-05-01 00:00:00

  • Use of three-dimensional ultrasonography in the evaluation of uterine perfusion and healing after laparoscopic myomectomy.

    abstract:OBJECTIVE:To evaluate vascular perfusion and uterine healing after laparoscopic myomectomy using three-dimensional power Doppler ultrasound (3D-PDU). DESIGN:Prospective study. SETTING:University-affiliated hospital. PATIENT(S):Ninety-seven women with symptomatic myomas warranting laparoscopic myomectomy. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Chang WC,Chang DY,Huang SC,Shih JC,Hsu WC,Chen SY,Sheu BC

    更新日期:2009-09-01 00:00:00

  • Transcervical intrafallopian transfer of zygotes.

    abstract::Reportedly, gamete intrafallopian transfer and zygote intrafallopian transfer are successful methods in assisted conception. This pilot study describes the experiences and results of a recently developed technique of vaginal transcervical intrafallopian transfer. In a group of 38 women with unexplained infertility, oo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Scholtes MC,Roozenburg BJ,Alberda AT,Zeilmaker GH

    更新日期:1990-08-01 00:00:00

  • The Lupron screening test: tailoring the use of leuprolide acetate in ovarian stimulation for in vitro fertilization.

    abstract:STUDY OBJECTIVE:To evaluate the prognostic and therapeutic value of a Lupron (leuprolide acetate; Tap Pharmaceuticals, North Chicago, IL) screening test before ovarian stimulation for in vitro fertilization (IVF). DESIGN:Prospective. SETTING:Outpatient IVF program. PATIENTS:Eighty patients exhibited four early estra...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Padilla SL,Smith RD,Garcia JE

    更新日期:1991-07-01 00:00:00

  • Human serum and follicular fluid stimulate hyperactivation of human spermatozoa after preincubation.

    abstract:OBJECTIVE:To test the effects of steroid-containing media such as follicular fluid (FF) and serum and of steroid-free but human protein-rich medium on hyperactivation (HA) of human spermatozoa with and without a preincubation period. DESIGN:Analysis of HA using a computer-aided sperm analysis system. SETTING:Academic...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kulin S,Bastiaans BA,Hollanders HM,Janssen HJ,Goverde HJ

    更新日期:1994-12-01 00:00:00

  • Pharmacodynamics of the antiprogesterone RU486 in women after oral administration.

    abstract::The pharmacokinetic characteristics of RU486 and its acute effects on anterior pituitary hormone secretion after oral administration were examined in six normal women. Serum RU486 concentrations were determined by a radioimmunoassay. The absorption of RU486 was rapid with peak serum levels reached approximately 90 min...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Liu JH,Garzo VG,Yen SS

    更新日期:1988-08-01 00:00:00

  • Bromelin for liquefaction of cervical mucus in sperm antibody testing: its effect on spermagglutinating immunoglobulin G.

    abstract::Incubation of cervical mucus with the proteolytic enzyme bromelin is known to result in complete liquefaction of the gel. This effect has been used in the detection spermagglutinating antibodies in cervical mucus. However, the well-known papain-like effect of bromelin on human immunoglobulin G (IgG) might be expected ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ingerslev HJ,Poulsen F

    更新日期:1980-01-01 00:00:00

  • Cytogenetic investigations on human oocytes and early human embryonic stages.

    abstract::The chromosome analysis of undivided oocytes and polyploid embryos within a human in vitro fertilization and embryo replacement program offers a unique opportunity to develop correlations between a successful or unsuccessful fertilization and the maturity of the oocytes or the quality of the sperm. Furthermore, it pro...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Michelmann HW,Mettler L

    更新日期:1985-02-01 00:00:00

  • Effect of oocyte quality on blastocyst development after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in a sheep model.

    abstract:OBJECTIVE:To compare blastocyst production, after IVF and ICSI, from sheep oocytes of various quality. Sham-injected oocytes and parthenogenetic activated oocyte groups were considered as control. DESIGN:Prospective experimental study. SETTING:University. ANIMAL(S):Three- to 6-month-old sheep. INTERVENTION(S):Oocyt...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Catalá MG,Izquierdo D,Rodríguez-Prado M,Hammami S,Paramio MT

    更新日期:2012-04-01 00:00:00

  • Differential expression of selected gene products in uterine leiomyomata and adenomyosis.

    abstract::Gene products estrogen receptor alpha, progesterone receptor-A, retinoid X receptor alpha, insulin-like growth factor-II, insulin-like growth factor I receptor beta, platelet-derived growth factor, epithelial growth factor receptor, and BCL-2 were examined by immunohistochemistry with the aid of a tissue microarray fr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Levy M,Mittal K,Chiriboga L,Zhang X,Yee H,Wei JJ

    更新日期:2007-07-01 00:00:00

  • Transurethral ablation of a prostatic utricle cyst with the use of a holmium laser.

    abstract:OBJECTIVE:To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser. DESIGN:Video presentation. SETTING:University hospital. PATIENT(S):A 33-year-old man presented with chronic pelvic pain, pain with ejaculation, and infertility. Semen ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sávio LF,Carrasquillo RJ,Dubin JM,Shah H,Ramasamy R

    更新日期:2018-12-01 00:00:00

  • Experimental contamination assessment of a novel closed ultravitrification device.

    abstract:OBJECTIVE:To evaluate the safety of a new ultravitrification closed device. DESIGN:Ultravitrification research. SETTING:Private assisted reproduction center. ANIMAL(S):Microorganisms (bacteria). INTERVENTION(S):A styrofoam container holding 1,000 mL of liquid nitrogen (LN2) was contaminated with Pseudomonas aerugin...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Criado E,Moalli F,Polentarutti N,Albani E,Morreale G,Menduni F,Levi-Setti PE

    更新日期:2011-04-01 00:00:00

  • Zygote intrafallopian transfer or in vitro fertilization and embryo transfer for the treatment of male-factor infertility: a prospective randomized trial.

    abstract:OBJECTIVE:To compare zygote intrafallopian transfer (ZIFT) and in vitro fertilization and embryo transfer (IVF-ET) as treatments of male-factor infertility. DESIGN:Patients were prospectively randomized to ZIFT or IVF-ET. SETTING:In vitro fertilization program of the Centre for Reproductive Medicine of the Dutch-spea...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Tournaye H,Devroey P,Camus M,Valkenburg M,Bollen N,Van Steirteghem AC

    更新日期:1992-08-01 00:00:00

  • Similar ongoing pregnancy rates after blastocyst transfer in fresh donor cycles and autologous cycles using cryopreserved bipronuclear oocytes suggest similar viability of transferred blastocysts.

    abstract::This retrospective cohort study compared blastocyst transfers in 136 fresh oocyte donor cycles and 69 autologous cycles using blastocysts derived from culture of thawed bipronuclear oocytes, all with oocytes derived from patients or donors less than 35 years old. The autologous cycles and oocyte donor cycles had simil...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Shapiro BS,Daneshmand ST,Garner FC,Aguirre M,Hudson C,Thomas S

    更新日期:2010-01-01 00:00:00

  • Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial.

    abstract:OBJECTIVE:Evaluate the effectiveness of a new ovarian stimulation (OS) protocol before IVF. DESIGN:Prospective clinical randomized trial. SETTING:Private centers. PATIENT(S):Three hundred and twenty-three intended-to-treat women candidates for IVF. INTERVENTION(S):Patients were divided into three groups and adminis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Serafini P,Yadid I,Motta EL,Alegretti JR,Fioravanti J,Coslovsky M

    更新日期:2006-10-01 00:00:00

  • Timing luteal support in assisted reproductive technology: a systematic review.

    abstract:OBJECTIVE:To summarize the available published randomized controlled trial data regarding timing of P supplementation during the luteal phase of patients undergoing assisted reproductive technology (ART). DESIGN:A systematic review. SETTING:Not applicable. PATIENT(S):Undergoing IVF. INTERVENTION(S):Different starti...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,评审


    authors: Connell MT,Szatkowski JM,Terry N,DeCherney AH,Propst AM,Hill MJ

    更新日期:2015-04-01 00:00:00

  • In utero exposures and the incidence of endometriosis.

    abstract:OBJECTIVE:To investigate the relation between the fetal environment and endometriosis. DESIGN:Prospective cohort study. SETTING:Nurses' Health Study II with 10 years of follow-up. PARTICIPANT(S):Eighty-four thousand, four hundred forty-six women aged 25-42 who had never been diagnosed with endometriosis, infertility...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Missmer SA,Hankinson SE,Spiegelman D,Barbieri RL,Michels KB,Hunter DJ

    更新日期:2004-12-01 00:00:00

  • Presence of soluble b-type cytochrome in human seminal fluid.

    abstract::In 1951 it was shown that human spermatozoa contained cytochromes a, b, and c. It was noted that the cytochromes were confined to the sperm and were not found in seminal fluid. More recently we have observed in seminal plasma a soluble component that has a typical spectrum of a reduced cytochrome b, but can be disting...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Trifunac NP,Bernstein GS

    更新日期:1981-03-01 00:00:00