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Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata.

Abstract：

:This study was intended to investigate the possible roles of the platelet-derived growth factor (PDGF) gene family's involvement in the pathogenesis of uterine leiomyomata. We examined the differential gene expressions of PDGF-A, -B, -C, -D, PDGF receptor alpha (PDGFR-alpha), and receptor beta (PDGFR-beta) between uterine leiomyomata and the adjacent normal myometrium. Expression of PDGF-C in leiomyomata was significantly higher (approximately 2.4-fold) than in the adjacent normal myometrium, whereas there were no significant differences in the expressions of PDGF-A, -B, -D, PDGFR-alpha, or PDGFR-beta between leiomyomata and the adjacent myometrial tissues.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Hwu YM,Li SH,Lee RK,Tsai YH,Yeh TS,Lin SY

doi

10.1016/j.fertnstert.2007.02.031

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

468-71

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(07)00501-8

journal_volume

89

pub_type

杂志文章

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