In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study.


OBJECTIVE:To assess in utero exposures and the odds of an endometriosis diagnosis. DESIGN:Matched cohort design. SETTING:Fourteen participating clinical centers in geographically defined areas in Utah and California. PATIENT(S):Operative cohort comprised 473 women undergoing laparoscopy/laparotomy, and an age- and residence-matched population cohort comprising 127 women undergoing pelvic magnetic resonance imaging (MRI), 2007-2009. INTERVENTION(S):None. MAIN OUTCOME MEASURE(S):Women completed standardized interviews before surgery or MRI regarding in utero exposures: mothers' lifestyle during the index pregnancy, and the index woman's gestation and birth size. Endometriosis was defined as visually confirmed disease in the operative cohort, and MRI visualized disease in the population cohort. The odds of an endometriosis diagnosis and corresponding 95% confidence intervals (CI) were estimated for each exposure by cohort using logistic regression and adjusting for current smoking, age at menarche, body mass index, and study site. RESULT(S):Endometriosis was diagnosed in 41% and 11% of women in the operative and population cohorts, respectively. In the primary analysis, adjust odds ratios (AORs) were elevated for maternal vitamin usage (1.27; 95% CI, 0.85-1.91), maternal cigarette smoking (1.16; 95% CI = 0.61-2.24), and low birth weight (1.1; 95% CI, 0.92-1.32). Reduced odds were observed for maternal usage of caffeine (0.99; 95% CI, 0.64-1.54), alcohol (0.82; 95% CI, 0.35-1.94), paternal cigarette smoking (0.72; 95% CI, 0.43-1.19), and preterm delivery (0.98; 95% CI, 0.47-2.03). Sensitivity analyses mostly upheld the primary results except for a decreased AOR for preterm birth (0.41; 95% CI, 0.18-0.94) when restricting to visualized and histologically confirmed endometriosis in the operative cohort. CONCLUSION(S):In utero exposures were not statistically significantly associated with the odds of an endometriosis diagnosis in either cohort.


Fertil Steril


Fertility and sterility


Wolff EF,Sun L,Hediger ML,Sundaram R,Peterson CM,Chen Z,Buck Louis GM




Has Abstract


2013-03-01 00:00:00














  • Cotyledonoid dissecting leiomyoma of the uterus.

    abstract::We describe a cotyledonoid dissecting leiomyoma in a 33-year-old nulliparous woman treated by laparoscopy. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Raga F,Sanz-Cortés M,Casañ EM,Burgues O,Bonilla-Musoles F

    更新日期:2009-04-01 00:00:00

  • Importance of the biopsy date in autologous endometrial cocultures for patients with multiple implantation failures.

    abstract:OBJECTIVE:To analyze the effectiveness of autologous endometrial coculture by the cycle day of the endometrial biopsy. DESIGN:Retrospective study. SETTING:University-based IVF center. PATIENT(S):Two hundred eight patients with multiple IVF failures. INTERVENTION(S):Embryos were split and randomly allocated to growt...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Spandorfer SD,Barmat LI,Navarro J,Liu HC,Veeck L,Rosenwaks Z

    更新日期:2002-06-01 00:00:00

  • Transcervical placement of a Malecot catheter after hysteroscopic evaluation provides for easier entry into the endometrial cavity for women with histories of difficult intrauterine inseminations and/or embryo transfers: a prospective case series.

    abstract:OBJECTIVE:To evaluate a new technique designed to improve access to the endometrial cavity through tortuous and/or stenotic endocervical canals in women with histories of difficult IUIs, ETs, or endometrial biopsies. DESIGN:Prospective case series. SETTING:Tertiary care center. PATIENT(S):Women with histories of dif...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Yanushpolsky EH,Ginsburg ES,Fox JH,Stewart EA

    更新日期:2000-02-01 00:00:00

  • Male obesity and alteration in sperm parameters.

    abstract:OBJECTIVE:To study the effect of male obesity on sperm parameters and erectile dysfunction. DESIGN:Retrospective analysis. SETTING:Referral fertility center. PATIENT(S):Couples presenting for infertility treatment. INTERVENTION(S):On presentation, all men reported their weight and height and filled out an intake fo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hammoud AO,Wilde N,Gibson M,Parks A,Carrell DT,Meikle AW

    更新日期:2008-12-01 00:00:00

  • Evaluation of endometrial tissue specific complement activation in women with endometriosis.

    abstract:OBJECTIVE:To determine if endometrial tissue specific complement (C) activation occurs in patients with endometriosis. DESIGN:Prospective. SETTING:University of Oklahoma Health Sciences Center, a tertiary care referral center. PATIENTS:Twenty-six women, 9 with endometriosis and 17 without endometriosis. INTERVENTIO...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: D'Cruz OJ,Wild RA

    更新日期:1992-04-01 00:00:00

  • Effects of pentoxifylline on human sperm motility in normospermic individuals using computer-assisted analysis.

    abstract:OBJECTIVE:To determine if pentoxifylline has an in vitro effect on human sperm motility in subjects with normal semen analysis. DESIGN:Prospective, longitudinal study of the effect of pentoxifylline on normospermic semen samples using computerized analysis. SETTING:The Assisted Conception Unit, Royal Maternity Hospit...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lewis SE,Moohan JM,Thompson W

    更新日期:1993-02-01 00:00:00

  • Changes of bioactive luteinizing hormone after laparoscopic ovarian cautery in patients with polycystic ovarian syndrome.

    abstract::The serum levels of bioactive luteinizing hormone (LH), immunoreactive LH, follicle-stimulating hormone, androstenedione (A), and testosterone (T) were determined in nine anovulatory women with polycystic ovarian syndrome (PCOS) before and after laparoscopic ovarian cautery. Eight ovulated spontaneously and three conc...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Sakata M,Tasaka K,Kurachi H,Terakawa N,Miyake A,Tanizawa O

    更新日期:1990-04-01 00:00:00

  • Inherited thrombophilia in infertile women: implication in unexplained infertility.

    abstract::Many studies evaluating a possible relationship between inherited thrombophilia and the etiology of unexplained infertility have been performed recently. No significant difference in the prevalence of three genetic mutations associated with the increased risk of thrombophilia (Factor V Leiden G1691A, prothrombin G2021...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Casadei L,Puca F,Privitera L,Zamaro V,Emidi E

    更新日期:2010-07-01 00:00:00

  • Hormone therapy use among postmenopausal French women before the publication of the Women's Health Initiative study: duration of use and factors associated with discontinuation.

    abstract:OBJECTIVE:Compliance with recent recommendations concerning hormone therapy (HT) requires that we understand the reasons why women receiving HT continue or stop their treatment. Our aim was to estimate the duration of HT use and analyze factors associated with its discontinuation during the period before the publicatio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ringa V,Varnoux N,Piault S,Bréart G

    更新日期:2005-06-01 00:00:00

  • 11beta-hydroxyandrostenedione and delta5-androstenediol as markers of adrenal androgen production in patients with 21-hydroxylase-deficient nonclassic adrenal hyperplasia.

    abstract:OBJECTIVE:To determine the sensitivity of 11beta-hydroxyandrostenedione (11-OHA4) and delta5-androstenediol (ADIOL) as markers of excessive adrenal androgen production. DESIGN:Prospective study. SETTING:Academic medical centers. PATIENT(S):Thirteen women with untreated 21-hydroxylase-deficient nonclassic adrenal hyp...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Huerta R,Dewailly D,Decanter C,Knochenhauer ES,Boots LR,Azziz R

    更新日期:1999-12-01 00:00:00

  • Micro-electrophoresis: a noninvasive method of sperm selection based on membrane charge.

    abstract:OBJECTIVE:To develop a technique with the potential of isolating genetically fit sperm for assisted reproductive technology (ART) treatment without compromising its structural or functional competence. DESIGN:Observational study. SETTING:University hospital. PATIENT(S):Fifty patients undergoing infertility diagnosis...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Simon L,Murphy K,Aston KI,Emery BR,Hotaling JM,Carrell DT

    更新日期:2015-02-01 00:00:00

  • Levels of androgens and danazol metabolites in serum during danazol therapy.

    abstract::Thirteen women who had endometriosis were treated with danazol (300 to 400 mg/d). Levels of androgens and danazol metabolites in serum and the influences of danazol metabolites on the assays for serum androgen were investigated during danazol therapy. Serum DHEAS significantly increased (P < 0.05), but serum DHEA slig...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murakami K,Nakagawa T,Yamashiro G,Araki K,Akasofu K

    更新日期:1993-07-01 00:00:00

  • Deoxyribonucleic acid repair and apoptosis in testicular germ cells of aging fertile men: the role of the poly(adenosine diphosphate-ribosyl)ation pathway.

    abstract:OBJECTIVE:To explore the relationship between men's age and DNA damage repair proteins related to apoptosis in human testicular germ cells. DESIGN:Retrospective case-control study. SETTING:Academic institutions. PATIENT(S):Testicular specimens were obtained from 22 fertile volunteers aged 20-82 years. INTERVENTION(...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: El-Domyati MM,Al-Din AB,Barakat MT,El-Fakahany HM,Xu J,Sakkas D

    更新日期:2009-05-01 00:00:00

  • Fertilization after standard in vitro fertilization versus intracytoplasmic sperm injection in subfertile males using sibling oocytes.

    abstract:OBJECTIVE:To compare conventional IVF with ICSI in the subfertile male population using sibling oocytes. Results from males with isolated severe teratozoospermia also are analyzed. DESIGN:Prospective experimental study. SETTING:University based IVF clinic. PATIENT(S):Group A: 18 patients with one or more abnormaliti...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pisarska MD,Casson PR,Cisneros PL,Lamb DJ,Lipshultz LI,Buster JE,Carson SA

    更新日期:1999-04-01 00:00:00

  • Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain.

    abstract:OBJECTIVE:To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility. DESIGN:Retrospective study using ELISA to measure peritoneal fluid I...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Akoum A,Al-Akoum M,Lemay A,Maheux R,Leboeuf M

    更新日期:2008-06-01 00:00:00

  • The efficiency of transvaginal ultrasonography in the diagnosis of endometrioma.

    abstract:OBJECTIVE:To assess the efficiency of transvaginal ultrasonography in the screening of endometriomas and in differentiating endometriomas from other ovarian masses. DESIGN:Prospective study with surgical and pathological confirmation of the sonographic diagnosis. SETTING:Department of Obstetrics and Gynecology at the...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Mais V,Guerriero S,Ajossa S,Angiolucci M,Paoletti AM,Melis GB

    更新日期:1993-11-01 00:00:00

  • Amino acid and protein concentrations of human follicular fluid.

    abstract::The amino acid and protein composition of human follicular fluid, obtained during surgery from women with polycystic ovaries, and of a simultaneously obtained sample of blood plasma were studied. In general, amino acid concentrations were higher in follicular fluid than in blood plasma: only the concentration of Cys w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Velazquez A,Reyes A,Chargoy J,Rosado A

    更新日期:1977-01-01 00:00:00

  • Impact of infertility treatments on the health of newborns.

    abstract:OBJECTIVE:To measure the use of infertility treatments in the general population and their association with neonatal health. DESIGN:Cross-sectional, population-based study. SETTING:Canton of Vaud, Switzerland; Etude du Developpement des Nouveau-nés (EDEN), a prospective study of chronic childhood conditions. PATIENT...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Addor V,Santos-Eggimann B,Fawer CL,Paccaud F,Calame A

    更新日期:1998-02-01 00:00:00

  • The basal body temperature chart in artificial insemination by donor pregnancy cycles.

    abstract::The basal body temperature (BBT) charts in pregnancy cycles of 110 consecutive women who became pregnant by a single heterologous insemination were studied. The occurrence of ovulation was proved by the pregnancies in each case. All of these pregnancy charts showed a biphasic pattern, and most followed one of three st...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Newill RG,Katz M

    更新日期:1982-10-01 00:00:00

  • The relationship between blastocyst morphology, chromosomal abnormality, and embryo gender.

    abstract:OBJECTIVE:To assess correlation between blastocyst morphology and chromosomal status. DESIGN:Observational research study. SETTING:An IVF clinic and a specialist preimplanation genetic diagnosis (PGD) laboratory. PATIENT(S):Ninety-three couples undergoing IVF treatment in combination with chromosome screening of emb...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Alfarawati S,Fragouli E,Colls P,Stevens J,Gutiérrez-Mateo C,Schoolcraft WB,Katz-Jaffe MG,Wells D

    更新日期:2011-02-01 00:00:00

  • Transforming growth factor (TGF)-beta1-induced human endometrial stromal cell decidualization through extracellular signal-regulated kinase and Smad activation in vitro: peroxisome proliferator-activated receptor gamma acts as a negative regulator of TGF-

    abstract:OBJECTIVE:To investigate the effect of transforming growth factor (TGF)-beta1 on the extracellular signal-regulated kinase (ERK) and Smad pathway and the role of peroxisome proliferator-activated receptor (PPAR)-gamma in cultured human endometrial stromal cells. DESIGN:Experimental study. SETTING:Infertility center o...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Chang HJ,Lee JH,Hwang KJ,Kim MR,Chang KH,Park DW,Min CK

    更新日期:2008-10-01 00:00:00

  • Quantification of mitochondrial DNA using real-time polymerase chain reaction in patients with premature ovarian failure.

    abstract:OBJECTIVE:To quantify mitochondrial DNA using real-time PCR in women with premature ovarian failure (POF) and a control group. DESIGN:Prospective study. SETTING:Genome Research Center for Reproductive Medicine and Infertility, Korea Ministry of Health & Welfare. PATIENT(S):Thrity patients with POF and 30 control ind...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Cha KY,Lee SH,Chung HM,Baek KH,Cho SW,Kwack KB

    更新日期:2005-12-01 00:00:00

  • One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.

    abstract:OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):M...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Lass A,Croucher C,Duffy S,Dawson K,Margara R,Winston RM

    更新日期:1998-12-01 00:00:00

  • The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions.

    abstract:OBJECTIVE:To determine whether the oncofetal protein IMP3 is detectable in endometriomas with or without histological atypia and whether IMP3 staining can be used as a triage tool to identify foci of atypical endometriosis in doubtful cases. DESIGN:Retrospective study. SETTING:Academic department and referral center ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Vercellini P,Cribiù FM,Del Gobbo A,Carcangiu ML,Somigliana E,Bòsari S

    更新日期:2013-06-01 00:00:00

  • The presence of the 21-hydroxylase deficiency carrier status in hirsute women: phenotype-genotype correlations.

    abstract:OBJECTIVE:To determine the role of heterozygosity for mutations in the 21-hydroxylase gene (CYP21) in the pathogenesis of hyperandrogenism. DESIGN:Controlled clinical study. SETTING:Tertiary care institutional hospital. PATIENT(S):Forty hirsute women and 13 healthy control women. INTERVENTION(S):The source of andro...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章


    authors: Escobar-Morreale HF,San Millán JL,Smith RR,Sancho J,Witchel SF

    更新日期:1999-10-01 00:00:00

  • Genetic variants in Ser-Arg protein-coding genes are associated with the risk of nonobstructive azoospermia in Chinese men.

    abstract:OBJECTIVE:To evaluate the association between genetic variants in Ser-Arg (SR) protein-coding genes and the susceptibility of nonobstructive azoospermia (NOA) in Chinese men. DESIGN:Case-control study. SETTING:State Key Laboratory of Reproductive Medicine in Nanjing Medical University conducted the genotyping and exa...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ni B,Ma H,Lin Y,Dai J,Guo X,Xia Y,Sha J,Hu Z

    更新日期:2014-06-01 00:00:00

  • Correlation of reactive oxygen species levels with the fertilization rate after in vitro fertilization: a qualified meta-analysis.

    abstract::Our meta-analysis analyzed the relationship between levels of reactive oxygen species (ROS) and fertilization rate after in vitro fertilization (IVF), and showed a statistically significant correlation between the ROS levels and the IVF fertilization rate (estimated overall correlation -0.374 [95% CI, -0.520, -0.205])...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析


    authors: Agarwal A,Allamaneni SS,Nallella KP,George AT,Mascha E

    更新日期:2005-07-01 00:00:00

  • Nicotine induces apoptosis in TM3 mouse Leydig cells.

    abstract:OBJECTIVE:To investigate whether nicotine-induced testicular toxicity involves the induction of apoptosis in Leydig cells. DESIGN:Cell study using cells of the TM3 cell line derived from mouse Leydig cells. SETTING:Academic research laboratory. INTERVENTION(S):Morphological and biochemical analyses for the detection...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kim KH,Joo KJ,Park HJ,Kwon CH,Jang MH,Kim CJ

    更新日期:2005-04-01 00:00:00

  • Poor implantation of cryopreserved reinsemination-fertilized human embryos.

    abstract:OBJECTIVE:To investigate whether a poor rate of implantation after in vitro fertilization (IVF) was due to poor embryonic/endometrial synchrony during the original IVF cycle, we have cryopreserved reinseminated-fertilized embryos for later more synchronous replacement after thawing. The chance of implantation of fresh ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tucker M,Elsner C,Kort H,Massey J,Mitchell-Leef D,Toledo A

    更新日期:1991-12-01 00:00:00

  • Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

    abstract:OBJECTIVE:To test the hypothesis that an acute reduction in circulating insulin affects LH secretion in women with polycystic ovary syndrome (PCOS). DESIGN:Prospective study in normal and PCOS women. SETTING:General Clinical Research Centers at the University of Virginia, the Medical College of Virginia, and the Mass...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Evans WS,Taylor AE,Boyd DG,Johnson ML,Matt DW,Jimenez Y,Nestler JE

    更新日期:2007-07-01 00:00:00