当前位置： SCI文献检索 > FERTILITY AND STERILITY期刊下所有文献 > A novel regimen of gonadotropin-releasing hormone (GnRH) antagonist plus pulsatile GnRH: controlled restoration of gonadotropin secretion and ovulation induction.

A novel regimen of gonadotropin-releasing hormone (GnRH) antagonist plus pulsatile GnRH: controlled restoration of gonadotropin secretion and ovulation induction.

Abstract：

:Using a primate model, we have tested a novel regimen of gonadotropin-releasing hormone (GnRH) antagonist plus pulsatile GnRH for the achievement of controlled restoration of gonadotropin secretion and ovulation induction. As a prelude, ovariectomized cynomolgus monkeys (n = 3) were treated with Antide ([N-Ac-D-Nal(2)1, D-pCl-Phe2, D-Pal(3)3, Lys(Nic)5, D-Lys(Nic)6, Lys(iPr)8, D-Ala10]-GnRH) (3 mg/kg per day) for 6 consecutive days. On the 7th day, pulsatile GnRH therapy was initiated in a 7 day-on: 7 day-off regimen for a total of four exposures. Next, four intact monkeys were given Antide to suppress ovarian function (estradiol less than 10 pg/mL) followed by pulsatile GnRH. In the ovariectomized monkeys, Antide-induced suppression of gonadotropin concentrations was reversed by the pulsatile GnRH so that follicle-stimulating hormone concentrations were completely normalized and luteinizing hormone concentrations were returned to within the lower range (+/- 2 SD) of the pretreatment mean. The abruptness of the onset or loss of gonadotropin secretion was precisely synchronized with the weekly on and off phases of the GnRH pulse regimen. In intact monkeys, ovarian steroid secretions were abruptly subdued and then successfully re-established by pulsatile GnRH in the face of sustained circulating levels of Antide. Thus, we conclude that our primate model of combination therapy, GnRH antagonist plus pulsatile GnRH, establishes the possibility of a new clinical treatment regimen for patients desiring relief from the sequelae of hyperandrogenemia (polycystic ovarian disease) and ovulatory dysfunction.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Gordon K,Williams RF,Danforth DR,Hodgen GD

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

1140-5

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(16)54018-7

journal_volume

54

pub_type

杂志文章

相关文献

FERTILITY AND STERILITY文献大全
  • Clinical studies with d-Trp 6-luteinizing hormone-releasing hormone in anovulatory women.

    abstract：:Nine anovulatory patients with hypothalamic-pituitary dysfunction were treated with d-Trp6-luteinizing hormone-releasing hormone, an analog with far greater gonadotropin-releasing activity than luteinizing hormone-releasing hormone. Four of eight patients, who were formerly unsuccessfully treated with clomiphene, huma...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：

    authors： Jaramillo CJ,Charro-Salgado A,Peréz-Infante V,del Campo GL,Botella-Llusiá J,Coy DH,Schally AV

    更新日期：1978-04-01 00:00:00

  • Blepharophimosis-ptosis-epicanthus inversus syndrome and hypergonadotropic hypogonadism.

    abstract：OBJECTIVE:To describe a woman with blepharophimosis-ptosis-epicanthus inversus syndrome and hypergonadotropic hypogonadism. DESIGN:Case report. SETTING:University medical center. PATIENT(S):One 25-year-old woman. INTERVENTION(S):Pedigree, hormone assays, and donor embryo transfer. MAIN OUTCOME MEASURE(S):Pregnancy...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2008.07.1763

    authors： Siewert AL,Stein Q,Flanagan J,Hansen KA

    更新日期：2008-11-01 00:00:00

  • Combination of metabolism measurement and a time-lapse system provides an embryo selection method based on oxygen uptake and chronology of cytokinesis timing.

    abstract：OBJECTIVE:To evaluate correlations between oxygen consumption (OC) measurements before and after embryo cytokinesis, observing OC during embryo cleavages and combining that information with morphokinetics to relate to implantation potential. DESIGN:Prospective cohort study. SETTING:University-affiliated private IVF u...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2016.03.019

    authors： Tejera A,Castelló D,de Los Santos JM,Pellicer A,Remohí J,Meseguer M

    更新日期：2016-07-01 00:00:00

  • Reproductive sequelae of parental severe illness before the pandemic: implications for the COVID-19 pandemic.

    abstract：OBJECTIVE:To investigate, with pre-COVID-19 data, whether parental exposure to severe systemic infections near the time of conception is associated with pregnancy outcomes. DESIGN:Retrospective cohort study. SETTING:Population-based study covering births within the United States from 2009 to 2016. PARTICIPANTS:The I...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2020.09.153

    authors： Kasman AM,Bhambhvani HP,Li S,Zhang CA,Stevenson DK,Shaw GM,Simard JF,Eisenberg ML

    更新日期：2020-12-01 00:00:00

  • Chlamydia antibody by enzyme-linked immunosorbent assay and associated severity of tubal factor infertility.

    abstract：:We have evaluated the clinical utility of the serum chlamydial antibody value by ELISA in predicting the severity of tubal factor infertility quantified by the use of a previously reported pelvic scoring system. Significant differences in salpingitis scores, tubal occlusion scores, adhesion scores, and pelvic stages w...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)55579-4

    authors： Minassian SS,Wu CH

    更新日期：1992-12-01 00:00:00

  • Stimulation of spermatogenesis with recombinant human follicle-stimulating hormone (follitropin alfa; GONAL-f): long-term treatment in azoospermic men with hypogonadotropic hypogonadism.

    abstract：OBJECTIVE:To demonstrate the efficacy and safety of follitropin alfa administered with hCG on spermatogenesis in adult male hypogonadotropic hypogonadism (HH) patients. DESIGN:Phase III, multicenter, open-label, noncomparative. SETTING:Seven US medical centers. PATIENT(S):A total of 36 adult males with severe HH. I...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.fertnstert.2008.07.1742

    authors： Matsumoto AM,Snyder PJ,Bhasin S,Martin K,Weber T,Winters S,Spratt D,Brentzel J,O'Dea L

    更新日期：2009-09-01 00:00:00

  • Prenatal hyperandrogenism and lipid profile during different age stages: an experimental study.

    abstract：OBJECTIVE:The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance. DESIGN:Experimental study. SETTING:Research institute. ANIMAL(S):Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, an...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.10.017

    authors： Heber MF,Ferreira SR,Vélez LM,Motta AB

    更新日期：2013-02-01 00:00:00

  • Two successful spontaneous pregnancies in a patient with a primary primitive neuroectodermal tumor of the ovary.

    abstract：OBJECTIVE:To describe a patient with primary primitive neuroectodermal tumor of the ovary with two successful spontaneous pregnancies. DESIGN:Case report. SETTING:Tertiary center for gynecologic oncology. PATIENT(S):A 25-year-old woman with two spontaneous pregnancies 5 months after and 2 years after conservative tr...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2003.08.036

    authors： Demirtas E,Guven S,Guven ES,Baykal C,Ayhan A

    更新日期：2004-03-01 00:00:00

  • Congenital interruption of the ampullary portion of the fallopian tube.

    abstract：:We present a rare case of a congenital isolated missing segment of the fallopian tube, including hysterosalpingographic and laparoscopic images. We conclude that when this occurs without concomitant müllerian anomalies, the mechanism of development would not be expected to be associated with an increase in renal abnor...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.01.012

    authors： Dahan MH,Burney R,Lathi R

    更新日期：2006-06-01 00:00:00

  • Separation efficiency of a microfluidic sperm sorter to minimize sperm DNA damage.

    abstract：OBJECTIVE:To evaluate whether microfluidic sperm sorters (MFSSs) allow effective recovery of sorted motile sperm without DNA damage compared with the centrifugation and swim-up procedure. DESIGN:Experimental laboratory study. All participants completed questionnaires regarding previous and/or current diseases, surgery...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.10.023

    authors： Shirota K,Yotsumoto F,Itoh H,Obama H,Hidaka N,Nakajima K,Miyamoto S

    更新日期：2016-02-01 00:00:00

  • Endometriosis and infertility: a committee opinion.

    abstract：:Women with endometriosis typically present with pelvic pain, infertility, or an adnexal mass, and may require surgery. Treatment of endometriosis in the setting of infertility raises a number of complex clinical questions that do not have simple answers. This document replaces the 2006 ASRM Practice Committee document...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.05.031

    authors： Practice Committee of the American Society for Reproductive Medicine.

    更新日期：2012-09-01 00:00:00

  • Proximal ectopic pregnancy: a descriptive general population-based study and results of different management options in 86 cases.

    abstract：OBJECTIVE:To describe different approaches for diagnosis and management of proximal ectopic pregnancies (PP) in general population. DESIGN:Observational population based-study. SETTING:Regional ectopic pregnancy registry. PATIENT(S):Eighty-six PP registered from 1992 to 2008. INTERVENTION(S):Surgical (radical or co...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.10.025

    authors： Larraín D,Marengo F,Bourdel N,Jaffeux P,Aublet-Cuvelier B,Pouly JL,Mage G,Rabischong B

    更新日期：2011-03-01 00:00:00

  • Classic congenital adrenal hyperplasia and its impact on reproduction.

    abstract：:Women with classic congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. In virilizing CAH forms, such as 21-hydroxylase and 11β-hydroxylase deficiency, the low reported pregnancy rate is mainly secondary to a dimin...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,评审

    doi：10.1016/j.fertnstert.2018.11.037

    authors： Gomes LG,Bachega TASS,Mendonca BB

    更新日期：2019-01-01 00:00:00

  • Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis.

    abstract：OBJECTIVE:To perform a systematic review and meta-analysis of studies that compared the prevalence of anxiety symptoms in women with polycystic ovary syndrome (PCOS) and control women. DESIGN:Meta-analysis and systematic review. SETTING:University practice. PATIENT(S):Cross-sectional studies comparing PCOS subjects ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.fertnstert.2011.10.022

    authors： Dokras A,Clifton S,Futterweit W,Wild R

    更新日期：2012-01-01 00:00:00

  • Live delivery outcome after tubal sterilization reversal: a population-based study.

    abstract：OBJECTIVE:To determine the cumulative incidence of live delivery in women who underwent reversal of tubal sterilization. DESIGN:Population-based retrospective cohort study. SETTING:Hospitals in Western Australia. PATIENT(S):All women aged 20-44 years, with a history of hospital admission for tubal sterilization, who...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2015.06.042

    authors： Malacova E,Kemp-Casey A,Bremner A,Hart R,Stewart LM,Preen DB

    更新日期：2015-10-01 00:00:00

  • Localization of angiotensin II, the AT1 receptor, angiotensin-converting enzyme, aminopeptidase A, adipocyte-derived leucine aminopeptidase, and vascular endothelial growth factor in the human ovary throughout the menstrual cycle.

    abstract：OBJECTIVE:To assess the expression and cellular distribution of angiotensin II (Ang II), angiotensin type 1 receptor (AT1R), angiotensin-converting enzyme (ACE), aminopeptidase A (APA), adipocyte-derived leucine aminopeptidase (A-LAP), and vascular endothelial growth factor (VEGF) in human ovarian tissue during the men...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.01.041

    authors： Harata T,Ando H,Iwase A,Nagasaka T,Mizutani S,Kikkawa F

    更新日期：2006-08-01 00:00:00

  • Metformin treatment in patients with polycystic ovary syndrome undergoing in vitro fertilization: a prospective randomized trial.

    abstract：:In the present study, we investigated the impact of metformin therapy on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in patients with polycystic ovary syndrome (PCOS). Metformin does not lead to any improvement in IVF/ICSI outcomes among patients with PCOS. ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2005.03.043

    authors： Onalan G,Pabuçcu R,Goktolga U,Ceyhan T,Bagis T,Cincik M

    更新日期：2005-09-01 00:00:00

  • Elevated serum estradiol associated with increased androstenedione-testosterone ratio in adolescent males with varicocele and gynecomastia.

    abstract：OBJECTIVE:To investigate the testicular function in adolescents with pubertal gynecomastia associated with varicocele before and after varicocelectomy. DESIGN AND PATIENTS:We have studied six male adolescents 15 to 19 years of age with bilateral gynecomastia. They were selected among other adolescents with gynecomasti...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)54551-8

    authors： Castro-Magana M,Angulo M,Uy J

    更新日期：1991-09-01 00:00:00

  • Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer.

    abstract：OBJECTIVE:To study the association of perinatal outcome and IVF transfer type in a group of infertility patients with standardized treatment and similar prognosis. DESIGN:Retrospective cohort study. SETTING:University-based infertility center, January 1998 to June 2006. PATIENT(S):Two hundred eighteen IVF pregnancie...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2010.05.049

    authors： Kansal Kalra S,Ratcliffe SJ,Milman L,Gracia CR,Coutifaris C,Barnhart KT

    更新日期：2011-02-01 00:00:00

  • Consecutive gonadotropin-releasing hormone-antagonist in vitro fertilization cycles: does the elapsed time interval between successive treatments affect outcomes?

    abstract：OBJECTIVE:To determine whether patients who failed an in vitro fertilization (IVF) cycle can proceed with a subsequent IVF cycle after waiting only one menstrual cycle, or whether there is a benefit to allowing two or more menstrual cycles to elapse before proceeding. DESIGN:Retrospective cohort study. SETTING:Academ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.11.044

    authors： Reichman DE,Chung P,Meyer L,Greenwood E,Davis O,Rosenwaks Z

    更新日期：2013-04-01 00:00:00

  • Terminology and core curricula in natural family planning.

    abstract：:22 physician-providers who serve natural family planning (NFP) programs, mostly in the private sector, gathered to formulate a standard terminology for the field. The Billings and sympto-thermal methods are the 2 methods taught by this group. The sypto-thermal method helps a woman predict ovulation by detecting chan...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(16)46409-5

    authors： Brennan JJ,Klaus H

    更新日期：1982-07-01 00:00:00

  • Contrast infusion sonography to assess microinsert placement and tubal occlusion after Essure.

    abstract：OBJECTIVE:To develop a technique for contrast infusion sonography and assess the possible use in determining microinsert placement and tubal status after Essure sterilization. DESIGN:Techniques and instrumentation. SETTING:Healthy women in an academic multispecialty group. PATIENT(S):Ten women desiring permanent ste...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.fertnstert.2005.10.075

    authors： Connor VF

    更新日期：2006-06-01 00:00:00

  • Location, color, size, depth, and volume may predict endometriosis in lesions resected at surgery.

    abstract：OBJECTIVE:To correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis. DESIGN:Prospective study. SETTING:U.S. government research hospital. PATIENT(S):Women with chronic pelvic pain thought to be due to endometriosis. INTERVENTION(S):Excision of lesions suspicious for end...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(02)03337-x

    authors： Stratton P,Winkel CA,Sinaii N,Merino MJ,Zimmer C,Nieman LK

    更新日期：2002-10-01 00:00:00

  • Role of environmental estrogens in the deterioration of male factor fertility.

    abstract：OBJECTIVE:To evaluate the role of the environmental estrogens polychlorinated biphenyls (PCBs) and phthalate esters (PEs) as potential environmental hazards in the deterioration of semen parameters in infertile men without an obvious etiology. DESIGN:Randomized controlled study. SETTING:Tertiary care referral inferti...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0015-0282(02)04389-3

    authors： Rozati R,Reddy PP,Reddanna P,Mujtaba R

    更新日期：2002-12-01 00:00:00

  • Mitochondrial activation in the growth-restricted fetus of monochorionic twins.

    abstract：OBJECTIVE:To study the regulatory mechanisms of selective intrauterine growth restriction (sIUGR) independent of confounding genetic factors, monochorionic (MC) twins are the ideal model, because they have identical genomic DNA. We hypothesize that the intrauterine growth restriction fetus has mitochondrial activation ...

    journal_title：Fertility and sterility

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.fertnstert.2013.03.003

    authors： Chang YL,Wang CN,Wei PC,Peng HH,Chao AS,Chang SD,Cheng PJ,Wang TH

    更新日期：2013-07-01 00:00:00

  • Treatment with gonadotropin-releasing hormone (GnRH) antagonists in women suppressed with GnRH agonist may avoid cycle cancellation in patients at risk for ovarian hyperstimulation syndrome.

    abstract：:Forty-seven patients at high risk for ovarian hyperstimulation syndrome because of markedly elevated serum E2 levels on either long-luteal or microdose flare leuprolide acetate regimens were treated with ganirelix acetate. Despite being pretreated with GnRH agonist and without withholding gonadotropins, serum E2 decre...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2005.07.1291

    authors： Gustofson RL,Larsen FW,Bush MR,Segars JH

    更新日期：2006-01-01 00:00:00

  • The expression of CD9 in the peri-implantation mouse uterus is upregulated in an ovarian steroid hormone-dependent manner.

    abstract：OBJECTIVE:To examine the spatiotemporal expression of CD9 protein in the peri-implantation mouse uterus as well as the effects of ovarian steroid hormones on CD9. DESIGN:Experimental animal study. SETTING:Reproductive biological center of Chinese Academy of Sciences. ANIMAL(S):Female Kunming white strain mice (6-8 w...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2006.07.1525

    authors： Weimin L,Yujing C,Jing L,Zeng H,Ping Z,Enkui D

    更新日期：2007-03-01 00:00:00

  • Effective treatment of severe menstrual migraine headaches with gonadotropin-releasing hormone agonist and "add-back" therapy.

    abstract：OBJECTIVE:To determine the efficacy of treating women with severe menstrual migraine headaches with GnRH agonist (GnRH-a) therapy, alone and combined with continuous estrogen-progestin "add-back." DESIGN:Nonrandomized, prospective treatment study. SETTING:Outpatient clinic in a university medical center. PATIENT(S):...

    journal_title：Fertility and sterility

    pub_type： 临床试验,杂志文章

    doi：10.1016/S0015-0282(97)81928-0

    authors： Murray SC,Muse KN

    更新日期：1997-02-01 00:00:00

  • Effects of hormone replacement therapy on cardiovascular risk factors in postmenopausal women.

    abstract：OBJECTIVE:To investigate changes in plasma lipoprotein profile, hemostatic factors, platelet aggregation, endothelin-1, and cardiac function during postmenopausal sequential 6-month hormone replacement therapy (HRT). DESIGN:Open longitudinal prospective study. SETTING:Gynecologic department of a medical center. PATI...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/s0015-0282(97)00487-1

    authors： Chen FP,Lee N,Wang CH,Cherng WJ,Soong YK

    更新日期：1998-02-01 00:00:00

  • Vitrification and xenografting of human ovarian tissue.

    abstract：OBJECTIVE:To assess the efficiency of two vitrification protocols to cryopreserve human preantral follicles with the use of a xenografting model. DESIGN:Pilot study. SETTING:Gynecology research unit in a university hospital. PATIENT(S):Ovarian biopsies were obtained from seven women aged 30-41 years. INTERVENTION(S...

    journal_title：Fertility and sterility

    pub_type： 杂志文章

    doi：10.1016/j.fertnstert.2012.07.1109

    authors： Amorim CA,Dolmans MM,David A,Jaeger J,Vanacker J,Camboni A,Donnez J,Van Langendonckt A

    更新日期：2012-11-01 00:00:00