Abstract:
:The health of children born through assisted reproductive technologies (ART) is particularly vulnerable to policy decisions and market forces that play out before they are even conceived. ART treatment is costly, and public and third-party funding varies significantly between and within countries, leading to considerable variation in consumer affordability globally. These relative cost differences affect not only who can afford to access ART treatment, but also how ART is practiced in terms of embryo transfer practices, with less affordable treatment creating a financial incentive to transfer more than one embryo to maximize the pregnancy rates in fewer cycles. One mechanism for reducing the burden of excessive multiple pregnancies is to link insurance coverage to the number of embryos that can be transferred; another is to combine supportive funding with patient and clinician education and public reporting that emphasizes a "complete" ART cycle (all embryo transfers associated with an egg retrieval) and penalizes multiple embryo transfers. Improving funding for fertility services in a way that respects clinician and patient autonomy and allows patients to undertake a sufficient number of cycles to minimize moral hazard improves outcomes for mothers and babies while reducing the long-term economic burden associated with fertility treatments.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Chambers GM,Keller E,Choi S,Khalaf Y,Crawford S,Botha W,Ledger Wdoi
10.1016/j.fertnstert.2020.08.1405subject
Has Abstractpub_date
2020-10-01 00:00:00pages
715-721issue
4eissn
0015-0282issn
1556-5653pii
S0015-0282(20)32162-2journal_volume
114pub_type
杂志文章,评审abstract::Polycystic ovarian syndrome (PCOS) appears to be due to a previously unrecognized type of steroidogenic abnormality, one in which hyperandrogenism arises from a regulatory abnormality (dysregulation) rather than from enzyme deficiency. It appears that PCOS typically arises from masculinized regulation of the androgen-...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:To compare the clinical and endocrinologic effects of cyproterone acetate (CPA), an antiandrogen with progestational activity; flutamide, a nonsteroidal antiandrogen, and finasteride, an inhibitor of 5alpha-reductase. DESIGN:Randomized, open, controlled clinical study. SETTING:Department of Obstetrics and G...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0015-0282(98)00486-5
更新日期:1999-03-01 00:00:00
abstract::This study fails to uphold the concept of invisible, microscopic endometriosis. Peritoneum devoid of disease exists, can be described, and can be consistently found. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60205-4
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:To investigate whether a history of previous ectopic pregnancy is an independent risk factor for failure of methotrexate therapy in subsequent ectopic pregnancies and whether the previous treatment method influenced failure. SETTING:Inner-city teaching hospital. DESIGN:Retrospective case review. PATIENT(S)...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.09.070
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To study the effects of hormone therapy on brain activation patterns during verbal memory in postmenopausal women. DESIGN:A randomized, double-blind placebo-controlled cross-over study was performed. SETTING:A tertiary care university medical center. PATIENT(S):Ten healthy postmenopausal women (age range 5...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2008.04.040
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:To characterize sperm parameters from thawed semen samples of men with different cancers who cryopreserved semen before oncologic therapy. DESIGN:Retrospective cohort study. SETTING:Tertiary academic medical center. PATIENT(S):1,010 semen samples collected between 1994 to 2010. INTERVENTION(S):None. MAIN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.09.031
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To demonstrate three approaches to uterine artery occlusion at time of myomectomy as a blood-sparing intraoperative technique. DESIGN:A step-by-step explanation of the procedure with surgical video footage. SETTING:Academic medical center. PATIENT(S):Patients undergoing laparoscopic myomectomy, for whom a ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2019.01.019
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To determine whether complete failure of fertilization of oocytes in couples with unexplained infertility persists during subsequent in vitro fertilization (IVF) cycles. DESIGN:A retrospective study of 120 cycles of IVF in 44 couples with unexplained infertility and complete failure of fertilization during t...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)55677-5
更新日期:1993-02-01 00:00:00
abstract:OBJECTIVE:To study the expression and function of adiponectin and its receptors in mouse and human follicle cells and in early embryo development. DESIGN:Whole ovaries, granulosa cells, and cumulus-oocyte complexes isolated from immature mice before and during hormone-induced ovulation were used to analyze the express...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2012.04.050
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of human oviductal cells on various sperm functions in vitro. DESIGN:Controlled experimental laboratory study. SETTING:University gynecology unit. PATIENT(S):Women undergoing tubal ligation or hysterectomy and men who were visiting our subfertility clinics. INTERVENTION(S):Cocult...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00430-0
更新日期:1999-02-01 00:00:00
abstract:OBJECTIVE:To review a 12-year experience of the world's three largest preimplantation genetic diagnosis (PGD) centers. DESIGN:Multicenter analysis of the clinical outcome of PGD. SETTING:In vitro fertilization programs at the Reproductive Genetics Institute, Chicago, Illinois; Saint Barnabas Medical Center, West Oran...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.09.082
更新日期:2004-08-01 00:00:00
abstract::A number of patients who have involuntary infertility show sperm antibodies in the blood serum, as detected by two quite different methods of spermagglutination. These techniques are the Kibrick method (gelatin agglutination test) and the F-D method (tube-slide agglutination test). By the former technique, the sera of...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)43158-4
更新日期:1978-03-01 00:00:00
abstract::The alkaloids ergocornine, vinblastine, and colcemide, with reported effects interfering with ovum implantation and development were investigated in the white New Zealand rabbit and the macaque monkey. 3 antimetabolites, 5-fluorouracil, 6-azauridine, and BW 57-323H, the 6 mercaptopurine derivative, were also investig...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)36181-7
更新日期:1967-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether circulating levels of antimüllerian hormone (AMH) predict fecundability in young healthy women. DESIGN:Prospective cohort study. SETTING:General community. PATIENT(S):A total of 186 couples who intended to discontinue contraception to become pregnant were followed until pregnancy or for...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.08.008
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To study the correlation between indices of air pollution and sperm parameters. DESIGN:Ecological study. SETTING:Contained geographic area. PATIENT(S):Resident men presenting for semen analysis or artificial insemination. INTERVENTION(S):Analysis of levels of particulate air pollution (particulate matter ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.12.089
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To determine whether the expression of leukemia inhibitory factor during the implantation window in endometrial tissue and uterine flushing fluid of patients with adenomyosis differs from that of healthy fertile women. DESIGN:Experimental study using endometrial tissue and uterine flushing fluid. SETTING:Pe...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.03.012
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To study the effect of human plasma from different sources, namely, umbilical cord blood and adult blood platelet-rich plasma (PRP), on the regeneration of endometrial damage. DESIGN:Composition analysis, in vitro approaches, and a preclinical murine model using plasma to promote endometrial regeneration. S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2020.07.053
更新日期:2020-08-24 00:00:00
abstract::The purpose of this article is to appraise the literature to ascertain whether the use of bariatric surgery should have a role in the contemporary management of the morbidly obese infertile patient before proceeding with infertility treatment. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2006.07.1499
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). DESIGN:Case-control studies published between January 1992 and ...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析
doi:10.1016/s0015-0282(00)01595-8
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To study the correlation between genital phenotype and cystic fibrosis genotype in men lacking at least one vas deferens. DESIGN:Prospective study. SETTING:Institut Rhônalpin pour la Reproduction Humaine, Lyon-Bron, France. PATIENT(S):Forty-seven infertile men lacking at least one vas deferens. INTERVENTI...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(02)02954-0
更新日期:2002-05-01 00:00:00
abstract::The association of insulin resistance, hyperandrogenism, and acanthosis nigricans is well established. The ovary is thought to be the site of the excess androgen production. The purpose of this study was to assess the adrenal contribution to the hyperandrogenic state in these women. Twenty-three patients presenting wi...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)50001-6
更新日期:1987-02-01 00:00:00
abstract::A case of a genital tuberculosis found during laparoscopic evaluation for recurrent acute pelvic pain is presented. The symptoms of genital tuberculosis can vary greatly, and a laparoscopic approach is effective for making the diagnosis. Clinicians should consider tuberculosis as a differential diagnosis when encounte...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2007.09.063
更新日期:2008-06-01 00:00:00
abstract::This bulletin will review the various viral etiologies of hepatitis, their mode of transmission, and implications for infertile couples, pregnant women, and health care workers. ...
journal_title:Fertility and sterility
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.fertnstert.2006.08.081
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. DESIGN:Meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. INTERVENTION(S):Infertile women treated with or witho...
journal_title:Fertility and sterility
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.fertnstert.2019.02.027
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the size of ovarian damage caused by ovarian drilling in polycystic ovary syndrome, the amount of inflicted damage was assessed for the most frequently used ovarian drilling techniques. DESIGN:Experimental prospective design. SETTING:University clinic. PATIENT(S):Six fresh bovine ovaries per te...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2008.10.046
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To compare obstetric and perinatal outcomes of singleton pregnancies resulting from embryos incubated in a time-lapse system (TLS) with those of embryos grown in standard IVF incubators (SI). DESIGN:Retrospective description of a cohort of patients who conceived during a randomized, controlled trial. SETTIN...
journal_title:Fertility and sterility
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.fertnstert.2017.06.031
更新日期:2017-09-01 00:00:00
abstract::Follow-up of 54 patients undergoing modified single-layer bilateral vasovasostomies are presented with attention to semen quality, pregnancy rates, and postoperative findings potentially inhibiting fertility. The technical success rate was 98%, but 3-month semen analyses varied from "poor" (less than 20(6)/ml; greater...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)47789-7
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE:To observe the ultrastructure of human oocytes at different maturity stages and morphologies before and after in vitro maturation. DESIGN:Case report. SETTING:University-based center for human reproduction. PATIENT(S):A 28-year-old patient with polycystic ovary syndrome undergoing IVM/IVF-ET treatment. IN...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2009.02.010
更新日期:2009-07-01 00:00:00
abstract::After long-term estradiol deficiency, female rats displayed body mass gain accompanied by an increase in the size of adipocytes, an increase in hyperglycemia, and a decrease in insulinemia. The effects were reversed by daily estradiol treatment. Adiposity was suggested by the increased vascular endothelial growth fact...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.01.020
更新日期:2011-03-15 00:00:00
abstract:OBJECTIVE:To evaluate the impact of dynamic in vitro culture on initiation of early follicular growth in prepubertal mouse ovaries. DESIGN:Ovaries from 8-day-old BALB/c mice were cultured either in a dynamic system (n=28) or in a static system (n=20) for 4 days. Uncultured 8-day-old (n=9) or 12-day-old (n=17) ovaries ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2014.05.038
更新日期:2014-09-01 00:00:00