Impact of reproductive history on in vitro fertilization and intracytoplasmic sperm injection outcome: evidence from the German IVF Registry.

Abstract:

OBJECTIVE:To evaluate the effect of reproductive history on the outcome of different procedures in assisted reproductive technologies (ART) comparing IVF, ICSI, and cryopreserved embryo transfer (CPE). DESIGN:Prospective registration of ART cycles and their outcomes. SETTING:One hundred three reproductive programs in Germany. PATIENT(S):Women undergoing 174,909 ART procedures from January 1998 through December 2000. INTERVENTION(S):Data analysis of reproductive history collected by the German IVF Registry; multiple logistic regression modeling of success rates. MAIN OUTCOME MEASURE(S):Effect of type of conception and outcome of previous pregnancies, duration of infertility, female's age, and type of ART on clinical pregnancy rate per retrieval. Odds ratios with 95% CIs are reported. RESULT(S):More than one previous pregnancy was negatively correlated with outcome of IVF, ICSI, or CPE. This association disappeared when female age was restricted to a maximum of 35 years. A previous pregnancy achieved by spontaneous conception had less impact on outcome of IVF, ICSI or CPE outcome than did a previous assisted conception. Previous live births and miscarriages demonstrated a statistically significant increase compared with ectopic pregnancies and induced abortions. CONCLUSION(S):Reproductive history must be considered when counseling subfertile couples. Female age, method of conception, and previous pregnancy outcome have a significant effect on IVF, ICSI, and CPE outcome.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Kupka MS,Dorn C,Richter O,Felberbaum R,van der Ven H

doi

10.1016/s0015-0282(03)00760-x

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

508-16

issue

3

eissn

0015-0282

issn

1556-5653

pii

S001502820300760X

journal_volume

80

pub_type

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