Abstract：
OBJECTIVE:To test the hypothesis that danazol increases the impedance to uterine circulation and hence reduces the effective uterine blood flow after a predetermined period of therapy. DESIGN:Prospective, longitudinal study. SETTING:Reproductive medicine unit of a university teaching hospital. PATIENT(S):Eight premenopausal women with dysfunctional uterine bleeding. INTERVENTION(S):Six weeks of danazol therapy. MAIN OUTCOME MEASURE(S):The uterine artery blood flow impedance as indicated by the pulsatility and resistance indices; the hormonal profile (E2, FSH, and LH levels); the uterine dimensions (length, width, anteroposterior diameter, and area); and the endometrial thickness. RESULT(S):The indices of uterine artery impedance were significantly increased after danazol therapy, indicating a possible reduction in the effective uterine artery blood flow. There was no statistically significant change in the hormonal profile, uterine dimensions, or endometrial thickness. CONCLUSION(S):Danazol therapy for 6 weeks results in a significant increase in the uterine artery impedance and hence a possible reduction in the effective uterine artery blood flow. This may explain in part its efficacy in the management of dysfunctional uterine bleeding and in the preoperative preparation of women undergoing endoscopic endometrial ablation. The exact mechanism for its action in this regard remains to be determined but appears to be independent of E2 levels. This preliminary finding may help in monitoring the treatment of dysfunctional uterine bleeding, preoperative and postoperative investigation of women undergoing endoscopic endometrial ablation, and the development of alternative treatment strategies for dysfunctional uterine bleeding in the future.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Pepper J,Dewart PJ,Oyesanya OAdoi
10.1016/s0015-0282(99)00161-2keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
66-70issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(99)00161-2journal_volume
72pub_type
杂志文章abstract：OBJECTIVE:To evaluate the effect of melatonin both on the ovaries of pinealectomized female rats through histomorphometric analysis and on steroid receptors, proliferating cell nuclear antigen (PCNA), and vascular endothelial growth factor (VEGF) expression. DESIGN:Experimental study. SETTING:Federal University of Sã...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.04.042
更新日期：2011-03-15 00:00:00
abstract：OBJECTIVE:To determine the size of the baboon corpus luteum (CL) and levels of plasma P, 17alpha-hydroxyprogesterone (17-OHP), and E2 in the ovarian vein draining it, the contralateral ovarian vein, and peripheral blood throughout the luteal phase of the menstrual cycle. DESIGN:Prospective study. SETTING:Academic dep...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.03.047
更新日期：2008-05-01 00:00:00
abstract：:Gonadotropin-releasing hormone (0.025 microgram/kg) was administered intravenously in a pulsatile fashion to four subjects with polycystic ovary syndrome for a total of six cycles. Five of the six cycles culminated in ovulation, although in one course the response occurred too early to be attributed to the therapy alo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To determine if estrogen ameliorates hot flashes by raising the core body temperature sweating threshold, by reducing core body temperature fluctuations, and/or by reducing sympathetic activation (as measured by plasma 3-methoxy-4-hydroxyphenylglycol). DESIGN:Laboratory physiological study. SETTING:Universi...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(01)03009-6
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVE:To compare the effects of intrauterine and subdermal administration of levonorgestrel on control of bleeding and on the endometrium in postmenopausal hormone replacement therapy. INTERVENTIONS:Nineteen women started continuous oral E2 valerate therapy (2 mg daily) together with continuous parenteral progesti...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(16)57365-8
更新日期：1995-02-01 00:00:00
abstract：OBJECTIVE:To report on chronic urinary retention after surgery for deep endometriosis and the possible risk factors for this complication. DESIGN:Descriptive study. SETTING:University hospital. PATIENT(S):Four patients with deep endometriosis who developed this complication. INTERVENTION(S):Laparoscopic surgery, in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.07.1043
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To evaluate whether intravaginal application of seminal plasma at the time of follicle aspiration in IVF or intracytoplasmic sperm injection treatment cycles has the potential to increase pregnancy rate. To calculate the number of patients needed to achieve significance in a multicenter trial. DESIGN:Double-...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.fertnstert.2007.11.036
更新日期：2009-01-01 00:00:00
abstract：:Patients undergoing controlled ovarian hyperstimulation and pituitary suppression with a GnRH antagonist who experienced a transient premature rise in LH were compared with those who did not have an early surge. Those experiencing a premature LH surge had equivalent clinical and ongoing pregnancy rates per ET. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.12.046
更新日期：2011-06-30 00:00:00
abstract：OBJECTIVE:To report the birth of a healthy female infant from a father with nonmosaic Klinefelter syndrome (KS) and document the experience of men with KS undergoing assisted conception. DESIGN:Retrospective. SETTING:Private IVF center. PATIENT(S):Twelve couples with male factor infertility due to Klinefelter syndro...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(03)01157-9
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVE:To assess patient response rates to medical therapies used to treat endometriosis-associated pain. DESIGN:A systematic review with the use of Medline and Embase. SETTING:Not applicable. PATIENT(S):Women receiving medical therapy to treat endometriosis. INTERVENTIONS(S):None. MAIN OUTCOME MEASURE(S):The p...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.fertnstert.2017.05.004
更新日期：2017-07-01 00:00:00
abstract：OBJECTIVE:To quantify the risk of recurrent early pregnancy loss in the presence of elevated fasting or afterload homocysteine concentrations or homozygosity for the 677C-->T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (T/T genotype). DESIGN:Case-control studies published between January 1992 and ...
journal_title：Fertility and sterility
pub_type： 杂志文章,meta分析
doi：10.1016/s0015-0282(00)01595-8
更新日期：2000-12-01 00:00:00
abstract：OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.01.100
更新日期：2013-05-01 00:00:00
abstract：OBJECTIVE:To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells. DESIGN:Laboratory-based study. SETTING:University-based research institute. PATIENT(S):None. INTERVENTION(S):The effect of P on the expression of NOS protein isoforms was examined in an in vitro p...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.05.019
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To compare conventional IVF with ICSI in the subfertile male population using sibling oocytes. Results from males with isolated severe teratozoospermia also are analyzed. DESIGN:Prospective experimental study. SETTING:University based IVF clinic. PATIENT(S):Group A: 18 patients with one or more abnormaliti...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0015-0282(98)00538-x
更新日期：1999-04-01 00:00:00
abstract：:Polycystic ovary disease generally is associated with elevated androgen levels and elevated luteinizing hormone (LH) levels, whereas follicle-stimulating hormone (FSH) levels are (sub)normal. To assess the role of androgens on gonadotropin secretion, we investigated the effect of 6 weeks of testosterone (T) undecanoat...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54194-6
更新日期：1991-03-01 00:00:00
abstract：:In an attempt to improve the motility of thawed spermatozoa after 1 week of its being frozen, we treated ten normal semen samples with 16.7 nmol relaxin and 6 mmol caffeine. Motility and grade of forward progression were examined after thawing. Caffeine significantly improved motility of spermatozoa. Relaxin, when add...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48868-0
更新日期：1985-09-01 00:00:00
abstract：OBJECTIVE:To assess the relevant factors affecting patients' decision when choosing a clinic for private, self-funded IVF treatment. DESIGN:Prospective anonymous closed questionnaires. SETTING:Single tertiary-care private IVF center. PATIENT(S):New patients attending primary consultation in a period of 7 months from...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01751-4
更新日期：2001-05-01 00:00:00
abstract：:Heterologous antibodies have frequently been used to develop assays in other species. Human urinary LH kits, widely available for predicting the LH surge, offer a unique opportunity to determine the timing of ovulation and mating in nonhuman primates. We tested three commercially available ovulation predictor kits for...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)53301-9
更新日期：1990-02-01 00:00:00
abstract：:A specially designed rigid salpingoscope has been developed to allow inspection of the tubal mucosa during laparoscopy. The presence and extent of intratubal adhesion formation can be evaluated more accurately by this technique than by either HSG or laparoscopy. In 22 patients with bilateral hydrosalpinges, an intraut...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60501-0
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVE:To determine the influence of estrogens on male fertility. DESIGN:A 36-year-old eugonadal male was subjected to two different regimens of treatment with ethinyl estradiol (EE2). Sperm quality, immunoreactive luteinizing hormone (LH) and follicle-stimulating Hormone (FSH), testosterone (T), estrone (E1), estr...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)55271-6
更新日期：1992-09-01 00:00:00
abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.08.053
更新日期：2013-10-07 00:00:00
abstract：:Levels of specific antibodies against model antigens, immunoglobulins G and A and also albumin, in oviductal fluid were studied in the rhesus monkey during the periovulatory period. Animals were systemically or intravaginally immunized against T4 coliphages. Attempts to induce ovulation were made with human menopausal...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：OBJECTIVE:To assess the occult pregnancy rate after "negative" first post-embryo transfer (ET) serum β-hCG results. DESIGN:Two-part retrospective cohort study and nested case series. SETTING:University-based fertility center. PATIENT(S):A total of 1,571 negative first post-ET serum β-hCG results were included in the...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.11.049
更新日期：2016-04-01 00:00:00
abstract：:Three groups of women with different types of ovulatory dysfunction who had failed to conceive on conventional therapy were treated with pulsatile gonadotropin-releasing hormone (GnRH). Group A consisted of nine patients with luteal phase defect; group B included four patients with apparently normal menstrual cycles b...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48971-5
更新日期：1985-11-01 00:00:00
abstract：OBJECTIVE:To measure the flow velocity of the uterine and ovarian arteries through the menstrual cycle to determine there are changes. DESIGN:Serial measurements throughout the menstrual cycle in women attending an infertility clinic, compared with volunteers coming for annual examinations. Transvaginal ultrasound-col...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54657-3
更新日期：1991-11-01 00:00:00
abstract：:Both partners of 198 consecutive infertile couples were evaluated. Studies in the female included clinical evaluation of ovulation for a minimum of two menstrual cycles, investigation of tubal patency, and evaluation of sperm survival in cervical mucus. Six semen specimens were analyzed from each male. Laparoscopy, sc...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42976-6
更新日期：1977-12-01 00:00:00
abstract：:We report a patient undergoing hMG-induced superovulation who demonstrated delayed excretion of hCG, originally believed to be because of successive biochemical pregnancies. However, sequential hCG titers after administration of exogenous hCG demonstrated a longer than normal half-life for the excretion of hCG in this...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54618-4
更新日期：1991-10-01 00:00:00
abstract：OBJECTIVE:To determine whether men with azoospermia are at an elevated risk of developing cancer in the years following an infertility evaluation. DESIGN:Cohort study. SETTING:United States andrology clinic. PATIENT(S):A total of 2,238 men with complete records were evaluated for infertility at a single andrology cl...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2013.05.022
更新日期：2013-09-01 00:00:00
abstract：:The health of children born through assisted reproductive technologies (ART) is particularly vulnerable to policy decisions and market forces that play out before they are even conceived. ART treatment is costly, and public and third-party funding varies significantly between and within countries, leading to considera...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2020.08.1405
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of nucleolar channel systems (NCSs) by uterine region, applying continuous quantification. DESIGN:Prospective clinical study. SETTING:Tertiary care academic medical center. PATIENT(S):Forty-two naturally cycling women who underwent hysterectomy for benign indications. INTERVENT...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2012.10.027
更新日期：2013-02-01 00:00:00
