Abstract：
OBJECTIVE:To determine intrauterine levels of vascular endothelial growth factor (VEGF)-A during the menstrual cycle in the human female and to investigate the impact of decidualization and corpus luteum function. DESIGN:Prospective clinical study. SETTING:Tertiary university center. PATIENT(S):Fifty-four women with infertility problems. INTERVENTION(S):Intrauterine concentrations of VEGF-A were determined at various time points during the secretory phase using a novel intrauterine microdialysis device. Concomitantly, intrauterine insulin-like growth factor binding protein (IGFBP)-1 levels served as a paracrine parameter for decidualization. Serum progesterone (P) and E(2) levels were determined as markers for corpus luteum function. Intrauterine VEGF levels. RESULT(S):The VEGF levels in utero were clearly cycle dependent with increasing levels during the late secretory and premenstrual phases. There was a significant correlation with the decidualization marker IGFBP-1. In contrast, intrauterine VEGF levels showed a significant negative correlation with serum E(2) and P. CONCLUSION(S):Intrauterine VEGF levels are regulated in a cycle-dependent way. Increasing levels in the late secretory phase are clearly correlated with decidualization. In contrast, decreasing serum levels of steroids produced by the regressing corpus luteum are less likely to be responsible for increasing VEGF levels in the premenstrual phase.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Licht P,Russu V,Lehmeyer S,Wissentheit T,Siebzehnrübl E,Wildt Ldoi
10.1016/s0015-0282(03)02165-4keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
1228-33issue
5eissn
0015-0282issn
1556-5653pii
S0015028203021654journal_volume
80pub_type
杂志文章abstract：OBJECTIVE:To confirm the advantages of goserelin prior to endometrial ablation for the treatment of dysfunctional uterine bleeding. DESIGN:Multicenter, prospective, randomized, double-blind study. PATIENT(S):Cycling premenopausal women with dysfunctional uterine bleeding. TREATMENT:Patients were randomized to gosere...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：1997-07-01 00:00:00
abstract：:Polycystic ovary syndrome presents with many different symptoms and signs, for which different therapies are indicated. However, for the majority of women, the metabolic disorder requires diligence in management, regardless of the presenting complaint. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2006.03.011
更新日期：2006-07-01 00:00:00
abstract：:Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...
journal_title：Fertility and sterility
pub_type：
doi：10.1016/j.fertnstert.2019.10.004
更新日期：2019-11-01 00:00:00
abstract：:The human chorionic gonadotropin (hCG) beta subunit curve of normal singleton in vitro fertilization (IVF) pregnancies shows cyclic peaks during the first 56 days after embryo transfer (ET). This phenomenon is not demonstrable in normal spontaneous conceptions. The hCG curves of 151 singleton IVF pregnancies achieved ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1986-11-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of frozen, compared with fresh, embryo transfer on neonatal and pediatric weight and weight gain trajectory. DESIGN:Retrospective cohort study. SETTING:Academic medical center. PATIENT(S):Women who underwent fresh or frozen embryo transfer at the Mayo Clinic from 2010 to 2014. All in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2019.05.020
更新日期：2019-10-01 00:00:00
abstract：:A detailed study was initiated to investigate thoroughly the possibility that any significant ophthalmologic changes might have occurred in patients using oral contraceptives (OCs) for varying periods. There were 212 patients and 50 control patients who were selected at random, 1/2 from private ophthalmology practice...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)35820-4
更新日期：1966-01-01 00:00:00
abstract：OBJECTIVE:To identify the value that women with pelvic inflammatory disease (PID) assign to the health impact of future infertility. DESIGN:Cross-sectional observations on patient preferences. SETTING:Participants in an existing multicenter clinical trial of PID treatment options. PATIENT(S):Five hundred thirty-two ...
journal_title：Fertility and sterility
pub_type： 杂志文章,多中心研究
doi：10.1016/j.fertnstert.2003.09.064
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:To assess cycle outcomes when antimüllerian hormone (AMH) is ultralow (≤0.16 ng/mL) and to determine which parameters contribute to the probability of cycle cancellation and/or outcome. DESIGN:Retrospective analysis. SETTING:Not applicable. PATIENT(S):5,087 (7.3%) fresh and 243 (1.5%) thawed cycles with ul...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.10.004
更新日期：2016-02-01 00:00:00
abstract：:Many will agree that the use of laparoscopy to diagnose and potientially treat endometriosis in patients who suffer from infertility has been superseded by IVF and sometimes oocyte donation, especially in older patients. The findings of our study add another dimension to management of endometriosis in the setting of i...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章,评审
doi：10.1016/j.fertnstert.2005.06.033
更新日期：2005-12-01 00:00:00
abstract：:Catecholamine concentrations were determined in left spermatic vein blood of 18 patients with varicocele. These values were compared with concentrations of catecholamines in the right femoral vein. Of 18 patients studied, 6 had moderate to marked elevations of spermatic vein catecholamine concentrations. Norepinephrin...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41541-4
更新日期：1975-12-01 00:00:00
abstract：:Nineteen vasectomized men were followed for 21 to 42 months after surgery, and their sera were tested for the presence of HL-A lymphocytoxic antibodies. In a previous study, the sera of two of these men had shown a definite increase in serum reactivity 6 to 12 months after surgery. Only one of the nineteen tested in t...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)42494-5
更新日期：1977-04-01 00:00:00
abstract：:Comparative studies have been carried out on the behavior of human and bovine spermatozoa toward homologous cervical mucus in vitro. In both cases the degree of sperm penetration and the pattern of sperm motility were influenced in a characteristic fashion by prior manipulation of the mucus: the most rapid and extensi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：OBJECTIVE:To report a case of bilateral ovarian fibromas and ovarian leiomyomas in a young patient with Gorlin syndrome and to highlight issues of fertility preservation, ovarian conservation, and preimplantation genetic diagnosis in this population. DESIGN:Case report. SETTING:University hospital. PATIENT(S):A 15-y...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2011.04.028
更新日期：2011-07-01 00:00:00
abstract：:The rapid postpartum return of gonadotropic function during bromocriptine treatment was investigated through hormonal measurements in 15 women. Luteinizing hormone (LH) was measured by a novel and specific assay that does not cross-react with human chorionic gonadotropin (hCG). Prolactin was effectively suppressed by ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60610-6
更新日期：1989-04-01 00:00:00
abstract：:Forty-four cycles with a spontaneous luteinizing hormone (LH) surge among 377 in vitro fertilization (IVF) patients were studied for outcome with different timing of oocyte retrieval. Mean number of preovulatory oocytes per retrieval and per transfer was significantly less in these cycles than in controls. Mean number...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)60131-0
更新日期：1988-09-01 00:00:00
abstract：OBJECTIVE:To assess perinatal risk of major congenital anomalies in children born after embryo transfer with assisted hatching (AH). DESIGN:Retrospective cohort study. SETTING:Not applicable. PATIENT(S):Cycles registered from 2010 to 2012 and conceived via single-embryo transfer were included for the analysis. Live ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.03.029
更新日期：2015-07-01 00:00:00
abstract：:We found, by reverse transcription--real time--polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, o...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章
doi：10.1016/j.fertnstert.2005.10.041
更新日期：2006-05-01 00:00:00
abstract：:This bulletin will review the various viral etiologies of hepatitis, their mode of transmission, and implications for infertile couples, pregnant women, and health care workers. ...
journal_title：Fertility and sterility
pub_type： 杂志文章,实务指引,评审
doi：10.1016/j.fertnstert.2006.08.081
更新日期：2006-11-01 00:00:00
abstract：:Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that assisted reproductive technology (ART) practitioners consider deferring donors who have recently received smallpox vaccine or contracted symptomatic vaccinia virus in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2003.12.013
更新日期：2004-04-01 00:00:00
abstract：OBJECTIVE:To investigate changes in menstrual cycle hormones and endometrial maturation that may contribute to the decline in fertility with aging. DESIGN:Prospective controlled clinical study. SETTING:Normal human volunteers in an academic research institution. SUBJECTS:Women with regular menstrual cycles. INTERVE...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:Certain conclusions may be drawn from the present review and presentation of new data concerning the unilaterally cryptorchid patient and possible subfertility: 1. The truly undescended testis--not the retractile testis of infancy--will not descend spontaneously after 1 year of age. 2. The seminal quality of the unila...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41889-3
更新日期：1976-06-01 00:00:00
abstract：:A study of the incidence of genital tract mycoplasmas in couples attending an infertility clinic and in a group of pregnant women showed that the frequency of isolation was significantly higher in the infertile group (P less than 0.001). In pregnancy, if mycoplasmas were isolated at the first prenatal visit, these org...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)47122-0
更新日期：1983-06-01 00:00:00
abstract：:Anaphylactic reaction associated with hysteroscopy using 32% dextran-70 as a distending medium is a rare phenomenon. We report anaphylactic reaction associated with hysteroscopy using dextran that was delivered manually in three otherwise healthy women occurring within a 6-month period. The rapidity and pressure of de...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54317-9
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVE:To investigate the mutation profiles and clinical characteristics of Chinese males with isolated hypogonadotropic hypogonadism (IHH) and discover new pathogenic genes that cause IHH. DESIGN:A gene panel, including 31 known IHH genes and 52 candidate genes, was used to perform semiconductor next-generation se...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2018.04.010
更新日期：2018-08-01 00:00:00
abstract：:Five patients with primary infertility and secondary amenorrhea who did not respond to clomiphene with a gonadotropin or estrogen surge were treated with 500 mug of luteinizing hormone, follicle-stimulating hormone-releasing hormone (LH-RH), self-administered subcutaneously every 8 hours for 14 days. Of four patients ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41890-x
更新日期：1976-06-01 00:00:00
abstract：OBJECTIVE:To assess live-birth defects after a luteal-phase ovarian-stimulation regimen (LPS) for in vitro fertilization (IVF) and vitrified embryo transfer (ET) cycles. DESIGN:Retrospective cohort study. SETTING:Tertiary-care academic medical center. PATIENT(S):Infants who were born between January 1, 2013 and May ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2015.02.020
更新日期：2015-05-01 00:00:00
abstract：OBJECTIVE:The response to subcutaneous (SC) gonadotropin replacement therapy, using human chorionic gonadotropin (hCG) and human menopausal gonadotropin (hMG) or hCG alone, was evaluated in male hypothalamic hypogonadism. DESIGN:Sixteen patients with hypothalamic hypogonadism were treated with gonadotropins for induct...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54493-8
更新日期：1991-08-01 00:00:00
abstract：:In view of the increasing emphasis being placed on patient safety and quality health care, it is extremely important to develop fail-safe mechanisms to prevent assisted reproductive technology (ART) mix-ups. Sample mismatch is the most undesirable event that can occur in an IVF laboratory as it may have catastrophic c...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2013.09.029
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN:Retrospective cohort study. SETTING:Academic reproductive medicine practice. PATIENT(S):Two hundred thirty-seven consecutive fresh donor oo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2017.05.021
更新日期：2017-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the outcome of repeated electroejaculation for obtaining semen from adolescents and young men before initiation of anticancer therapies. DESIGN:Retrospective clinical study. SETTING:Bikur Cholim Hospital, Jerusalem, Israel. PATIENT(S):Six young male patients (average age, 18+/-3 years) with dia...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(01)01680-6
更新日期：2001-04-01 00:00:00
