Abstract：
:A prospective, randomized, double-blind study with crossover, using tamoxifen (TAM) (Nolvadex, ici Pharma, Missisauga, Canada) 20 mg/day and placebo (p) for 6 months each, was conducted in 16 infertile men with idiopathic oligozoospermia. Baseline sperm count was 17.092 +/- 3.09 (10(6)/ml). Hormonal profile was performed and included follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), thyroid-stimulating hormone (TSH), and luteinizing hormone-releasing hormone (LH-RH) stimulation tests. The sperm analysis and hormonal profile were repeated at 6 and 12 months of the study. A sperm penetration assay (SPA) was performed on zona-free hamster egg. Compared with the placebo group, the TAM group showed a significant increase in plasma FSH, LH, E2, and T levels (P less than 0.001), but not in PRL and TSH levels. However, LH-RH stimulation tests and SPA were found to be comparable in the two treatment groups, and there was no significant effect on sperm analysis. Tamoxifen appeared to be no more effective than the placebo in the treatment of idiopathic oligozoospermia.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
AinMelk Y,Belisle S,Carmel M,Jean-Pierre Tdoi
10.1016/s0015-0282(16)59299-1subject
Has Abstractpub_date
1987-07-01 00:00:00pages
113-7issue
1eissn
0015-0282issn
1556-5653pii
S0015-0282(16)59299-1journal_volume
48pub_type
临床试验,杂志文章,随机对照试验abstract：OBJECTIVE:To test the hypothesis that oligo-ovulatory ovulation is associated with hyperandrogenemia in the absence of other clinical signs of androgen excess. DESIGN:Retrospective cohort controlled. SETTING:Tertiary care university-based outpatient clinic. PATIENT(S):Thirty-two consecutive nonhirsute oligo-ovulator...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(97)80089-1
更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE(S):To investigate the pattern of follicular development in transplanted fetal and neonatal mouse ovaries in the presence or absence of the recipient's own ovaries. DESIGN:Controlled experiment. SETTING:Academic research laboratory, Department of Physiology, Monash University, Clayton, Australia. INTERVENTI...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(00)00635-x
更新日期：2000-08-01 00:00:00
abstract：:Eighteen premenopausal women with symptomatic leiomyomata uteri were enrolled in a stratified, randomized, double-blind, placebo-controlled study evaluating the efficacy of leuprolide acetate (LA) depot treatment before myomectomy. Stratification was based on pretreatment uterine volume (less than 600 cm3 versus great...
journal_title：Fertility and sterility
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-11-01 00:00:00
abstract：OBJECTIVE:To report on chronic urinary retention after surgery for deep endometriosis and the possible risk factors for this complication. DESIGN:Descriptive study. SETTING:University hospital. PATIENT(S):Four patients with deep endometriosis who developed this complication. INTERVENTION(S):Laparoscopic surgery, in...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2010.07.1043
更新日期：2011-02-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between sperm chromatin structure assay (SCSA) parameters, DNA fragmentation index (DFI) and high DNA stainability (HDS), and outcomes of IVF and intracytoplasmic sperm injection (ICSI). DESIGN:Retrospective review and prospective study. SETTING:Academic human reproduction la...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2007.06.018
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVE:The embryo transfer is a critical part of in vitro fertilization. When performed under abdominal ultrasound guidance, the embryo transfer procedure requires a full bladder. Patients often state that the discomfort of the distended bladder causes more pain than the actual transfer procedure. Phenazopyridine HC...
journal_title：Fertility and sterility
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.fertnstert.2006.08.097
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:To establish the relative frequency of aneuploidy in sperm from normal and abnormal subjects using dual color fluorescence in situ hybridization and probes for six different chromosomes. DESIGN:Semen from 33 normal males and a patient with a translocation was studied using dual color fluorescence in situ hyb...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56896-4
更新日期：1994-08-01 00:00:00
abstract：OBJECTIVE:To assess the relationship between the results of the Sperm Quality Analyzer (United Medical Systems Inc., Santa Ana, CA), which measures motile sperm concentration by light scattering, conventional manual semen analysis characteristics, and computer-assisted sperm motility analyses. DESIGN:Sperm Quality Ana...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To define a therapeutic strategy adapted to acute urine retention resulting from uterine incarceration in early pregnancy. DESIGN:Case report and review of the literature. SETTING:University hospital. PATIENT(S):Two cases of acute urine retention induced by severe fibroid incarceration in first trimester. ...
journal_title：Fertility and sterility
pub_type： 杂志文章,评审
doi：10.1016/j.fertnstert.2007.10.008
更新日期：2008-10-01 00:00:00
abstract：OBJECTIVE:To explore the effectiveness of percutaneous vasal sperm aspiration (PVSA) in combination with intrauterine insemination (IUI) to treat infertile men with anejaculation. DESIGN:Clinical study. SETTING:Department of reproductive endocrinology and andrology of a family planning research clinic. PATIENT(S):Tw...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(02)04697-6
更新日期：2003-03-01 00:00:00
abstract：:We report a rare ovarian pregnancy after in vitro fertilization and transcervical embryo transfer. Ultrasound guidance of embryo transfer does not eliminate the risk of this potentially lethal complication. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.02.026
更新日期：2008-02-01 00:00:00
abstract：:Polyovular follicles were found in 61 (24%) of 251 laparoscopies performed for in vitro fertilization. Of 898 follicles that contained at least one oocyte, 76 (8%) were polyovular. When the oocytes from polyovular follicles were assessed by morphologic criteria, it was found that 46 of the follicles contained oocytes ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of the 2004 Italian regulations (insemination of journal_title：Fertility and sterility pub_type： 杂志文章 doi：10.1016/j.fertnstert.2007.04.051 更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To survey the level of disclosure of conception method within families of children conceived by conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) and to examine the factors that might influence parental attitudes and plans for disclosure. DESIGN:In-depth questionnaire. SET...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2004.12.019
更新日期：2005-04-01 00:00:00
abstract：:Ovaries isolated from rats in different stages of the sex cycle were explored for spontaneous or drug-induced contractile activity. The number of spontaneously active ovaries as well as the magnitude of the isometrically developed tension and frequency of contractions were greater during the periovulatory interval (la...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41724-3
更新日期：1976-03-01 00:00:00
abstract：:Bacterial endotoxin was detected in menstrual effluent from infertile women. Endometrial endotoxin appears to influence reproductive process because the pregnancy rate after IVF-ET was significantly associated with an endotoxin level. ...
journal_title：Fertility and sterility
pub_type： 评论,杂志文章
doi：10.1016/j.fertnstert.2004.06.030
更新日期：2004-10-01 00:00:00
abstract：:The effectiveness of ovulation induction with clomiphene citrate or human menopausal gonadotropins was evaluated in 52 infertile women with stage I or stage II endometriosis and ovulatory dysfunction: anovulation or luteinized unruptured follicle (LUF) syndrome before (group I) and after (group II) danazol treatment. ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)49811-0
更新日期：1986-11-01 00:00:00
abstract：:A highly sensitive 2-hour tube test for the detection of human chorionic gonadotropin (hCG) in urine was compared with the more resource-demanding radioimmunoassay for hCG in serum as an aid in the diagnosis of ectopic pregnancy. In a first series of 107 patients with the possibility of ectopic pregnancy, the urine te...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)48559-6
更新日期：1985-05-01 00:00:00
abstract：:The level of the "Beaumont" protein present in serum was measured by a population of 223 black and 76 Caucasian women with different exposures to oral contraceptives (OCs). No differences were found in the values in nonusers, past users, current users, or new users of OCs. The values were higher in black nonusers and ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：OBJECTIVE:To evaluate the association of an activating single-nucleotide polymorphism (SNP) at position -71 of the promoter of 17beta-hydroxysteroid dehydrogenase type 5 gene (-71A/G HSD17B5 SNP) and polycystic ovary syndrome (PCOS) in a well characterized cohort of caucasian PCOS women with biochemical hyperandrogenem...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2008.06.016
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To compare androgen responses during ACTH infusion among women with polycystic ovary syndrome (PCOS) and healthy women. DESIGN:Cross-sectional study. SETTING:Academic medical center. PATIENT(S):Women with PCOS (n = 13) and healthy controls (n = 15). INTERVENTION(S):Blood samples were obtained frequently d...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2016.06.039
更新日期：2016-10-01 00:00:00
abstract：:The result of the hormone concentration of one blood sample was used to determine the accuracy of predicting not only the hormone concentrations of a second and third sample drawn 15 minutes apart, but also the mean value of the three samples. Three blood specimens from 73 men involved in two previously reported studi...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)59662-9
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To investigate the relationship between growth hormone (GH) and luteal function. DESIGN:In vivo comparative and in vitro culture studies. SETTING:University hospital. PATIENT(S):Eighteen women who were interested in becoming pregnant and visited our clinic voluntarily participated in the study for urinary ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2007.07.1304
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:To evaluate the use of sonohysterography for uterine screening before IVF. DESIGN:Prospective screening with sonohysterography and comparison with available hysterosalpingographic and hysteroscopic evaluations. SETTING:Private practice. PATIENT(S):Seventy-two women undergoing IVF-ET using their own or dono...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(98)00045-4
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVE:To determine the sensitivity of 11beta-hydroxyandrostenedione (11-OHA4) and delta5-androstenediol (ADIOL) as markers of excessive adrenal androgen production. DESIGN:Prospective study. SETTING:Academic medical centers. PATIENT(S):Thirteen women with untreated 21-hydroxylase-deficient nonclassic adrenal hyp...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(99)00402-1
更新日期：1999-12-01 00:00:00
abstract：OBJECTIVE:To analyze rates of chromosomal anomalies in a patient with globozoospermia. DESIGN:Case report. SETTING:Tertiary-care infertility clinic. PATIENT(S):A 44-year-old man with 100% globozoospermia. INTERVENTION(S):Fixation of sperms and analysis of aneuploidies and diploidies by fluorescence in situ hybridiz...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/j.fertnstert.2005.01.109
更新日期：2005-07-01 00:00:00
abstract：:This study describes the results with immature human follicular oocytes harvested from unstimulated ovaries, matured in vitro, fertilized, and transferred to an agonadal recipient. Two hundred seventy immature oocytes were aspirated from 23 ovaries removed for various gynecological indications from August 1988 to Octo...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)54068-0
更新日期：1991-01-01 00:00:00
abstract：:In this study of 132 infertile couples, findings with hysterosalpingography (HSG) were compared with those observed at subsequent culdoscopy or laparoscopy. Both procedures correctly revealed normal tubes in 29% of the subjects and identical abnormalities in 24%. A complete agreement between the two procedures was thu...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)41531-1
更新日期：1975-12-01 00:00:00
abstract：OBJECTIVE:To determine whether mutations in the gene for FSH beta are present, and possibly etiologic, in some patients with 46,XX premature ovarian failure (POF). DESIGN:DNA samples obtained from 18 study patients with POF and two menopausal fertile controls were studied by Southern blot analysis. DNA sequencing was ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：10.1016/s0015-0282(16)56286-4
更新日期：1993-11-01 00:00:00
abstract：:The effects of estradiol (E2) administered by a transdermal system on the induction of hypothalamic opioid activity was examined in 18 postmenopausal women. Women were given 25, 50, 100, or 200 micrograms/d dosages of E2 for 28 days each. Naloxone at a dosage of 2 mg/h was infused intravenously for 4 hours, and serum ...
journal_title：Fertility and sterility
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
