Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity.


:Endometrial polyps, adenomyosis, and leiomyomas are commonly encountered abnormalities frequently found in both fertile women and those with infertility. The clinician is frequently challenged to determine which of these entities, when found, is likely to impair fertility, and which are "innocent bystanders" unrelated to the problem at hand. Although removing an endometrial polyp may be seen as a relatively benign and safe intervention, myomectomy, and in particular adenomyomectomy, can be substantive surgical procedures, associated with their own potential for disrupting fertility. One of the mechanisms thought to be involved when these entities are contributing to infertility is an adverse impact on endometrial receptivity. Indeed polyps, adenomyosis, and leiomyomas have all been associated with an increased likelihood of abnormal endometrial molecular expressions thought to impair implantation and early embryo development. This review is designed to examine the relationship of these common entities to endometrial receptivity and to identify evidence gaps that should be considered when strategizing research initiatives. It is apparent that we have the tools necessary to fill these gaps, but it will be necessary to approach the issue in a strategic and coordinated fashion. It is likely that we will have to recognize the limitations of imaging alone and look to the evidence-based addition of molecular analysis to provide the individualized phenotyping of disease necessary for patient-specific treatment decisions.


Fertil Steril


Fertility and sterility


Munro MG




Has Abstract


2019-04-01 00:00:00














  • A meta-analysis of ultrasound-guided versus clinical touch embryo transfer.

    abstract:OBJECTIVE:To determine the relative efficacy of ultrasound-guided embryo transfer and embryo transfer by clinical touch alone. DESIGN:Systematic review and meta-analysis of randomized, controlled trials comparing ultrasound-guided embryo transfer with embryo transfer by clinical touch alone. SETTING:Infertility cente...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Buckett WM

    更新日期:2003-10-01 00:00:00

  • Total number of oocytes and zygotes are predictive of live birth pregnancy in fresh donor oocyte in vitro fertilization cycles.

    abstract:OBJECTIVE:To evaluate the association of oocyte donor-recipient characteristics, oocyte donor response, and live birth pregnancy rate following fresh donor oocyte IVF-ET. DESIGN:Retrospective cohort study. SETTING:Academic reproductive medicine practice. PATIENT(S):Two hundred thirty-seven consecutive fresh donor oo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hariton E,Kim K,Mumford SL,Palmor M,Bortoletto P,Cardozo ER,Karmon AE,Sabatini ME,Styer AK

    更新日期:2017-08-01 00:00:00

  • Abdominal pregnancy complicated by genital and renal tuberculosts and hemolytic anemia.

    abstract::After a 10-year period of primary infertility, a patient presented with abdominal pregnancy. Known to have had previously treated genital tuberculosis, on admission she was found to have renal tuberculosis and autoimmune hemolytic anemia. After fetal death, laparotomy was performed and the fetus was removed. The patie...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Semchyshyn S,Cecutti A

    更新日期:1975-11-01 00:00:00

  • Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells.

    abstract::Hypoxia downregulated the concentration of endostatin in the culture media of human endometrial stromal cells but did not affect the messenger (m)RNA expression of collagen XVIII. Both mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition. ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nasu K,Nishida M,Fukuda J,Kawano Y,Nishida Y,Miyakawa I

    更新日期:2004-09-01 00:00:00

  • A prospective, randomized study of pregnancy rates after transuterotubal and intrauterine insemination.

    abstract:OBJECTIVE:To assess the relative efficacy, in terms of clinical pregnancy rates (PRs), of transuterotubal insemination versus the more traditional intrauterine insemination (IUI) procedure. DESIGN:Prospective, randomized, cross-over. SETTING:University-affiliated tertiary care center. PATIENTS:One hundred sixty infe...

    journal_title:Fertility and sterility

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Oei ML,Surrey ES,McCaleb B,Kerin JF

    更新日期:1992-07-01 00:00:00

  • In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study.

    abstract:OBJECTIVE:To assess in utero exposures and the odds of an endometriosis diagnosis. DESIGN:Matched cohort design. SETTING:Fourteen participating clinical centers in geographically defined areas in Utah and California. PATIENT(S):Operative cohort comprised 473 women undergoing laparoscopy/laparotomy, and an age- and r...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Wolff EF,Sun L,Hediger ML,Sundaram R,Peterson CM,Chen Z,Buck Louis GM

    更新日期:2013-03-01 00:00:00

  • Use of laparoscopically mobilized peritoneum in the creation of a neovagina.

    abstract:OBJECTIVE:To present an alternative technique for the creation of a neovagina. DESIGN:Case study. SETTING:Academic university gynecology clinic. PATIENT(S):A patient diagnosed with müllerian agenesis. INTERVENTION(S):Laparoscopically assisted creation of a neovagina by using peritoneum. MAIN OUTCOME MEASURE(S):Pat...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Templeman CL,Hertweck SP,Levine RL,Reich H

    更新日期:2000-09-01 00:00:00

  • Empty follicle syndrome: the reality of a controversial syndrome, a systematic review.

    abstract:OBJECTIVES:To examine all case reports and studies of empty follicle syndrome (EFS) that have been published since the condition was first reported, in an attempt to identify trends or common features that may expose possible risk or causative factors. DESIGN:Systematic review of all available literature obtained from...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Stevenson TL,Lashen H

    更新日期:2008-09-01 00:00:00

  • An analysis of endometrial biopsies performed for infertility.

    abstract::The authors evaluated 774 endometrial biopsies that were performed for infertility. Complications arose in 3.6%. Lag of more than 2 days was found in 19%; luteal phase defect (LPD) was diagnosed in 5.7%. Most of the incidence of LPD can be predicted from chance occurrence. There was no association between abnormal bio...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Davidson BJ,Thrasher TV,Seraj IM

    更新日期:1987-11-01 00:00:00

  • Nicotine induces apoptosis in TM3 mouse Leydig cells.

    abstract:OBJECTIVE:To investigate whether nicotine-induced testicular toxicity involves the induction of apoptosis in Leydig cells. DESIGN:Cell study using cells of the TM3 cell line derived from mouse Leydig cells. SETTING:Academic research laboratory. INTERVENTION(S):Morphological and biochemical analyses for the detection...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Kim KH,Joo KJ,Park HJ,Kwon CH,Jang MH,Kim CJ

    更新日期:2005-04-01 00:00:00

  • Future fertility after prenatal exposure to cigarette smoke.

    abstract::We tested the hypothesis that prenatal exposure to cigarette smoke is associated with impaired fertility in adulthood. Fertility for nearly 600 couples was quantified by counting the number of noncontraception cycles required to conceive. Exposure in utero was assessed by asking couples about their parents' cigarette ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Baird DD,Wilcox AJ

    更新日期:1986-09-01 00:00:00

  • Essure treatment of hydrosalpinges.

    abstract:OBJECTIVE:To describe the use of Essure microinsert placement in patients with hydrosalpinges before IVF. DESIGN:Retrospective case-series. SETTING:An advanced endoscopic practice within a university-affiliated teaching hospital. PATIENT(S):Five women with unilateral or bilateral hydrosalpinges on transvaginal ultra...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Hitkari JA,Singh SS,Shapiro HM,Leyland N

    更新日期:2007-12-01 00:00:00

  • Patient satisfaction and clinical outcome after injecting gonadotropins with use of a needle-free carbon dioxide injection system for controlled ovarian hyperstimulation for in vitro fertilization.

    abstract::In this prospective, randomized clinical trial, we tested the hypothesis that a needle-free CO(2) injection system (Biojector 2000) would be better tolerated by patients when compared with traditional sharp needles used for gonadotropin injections during stimulation for IVF. As measured by our questionnaire, the needl...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Solnica A,Oh C,Cho MM,Loughlin JS,McCulloh DH,McGovern PG

    更新日期:2009-10-01 00:00:00

  • Human ovarian receptors to human prolactin: implications in infertility.

    abstract::In the human, hyperprolactinemia may interfere with fertility. To find out whether or not prolactin (PRL) can act directly on human ovarian tissues, in vitro studies involving specific binding of human PRL to various human ovarian elements were carried out. Human PRL was isolated from amniotic fluid, and its intact mo...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ben-David M,Schenker JG

    更新日期:1982-08-01 00:00:00

  • Sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women: a randomized, double blind, placebo-controlled trial.

    abstract:OBJECTIVE:To evaluate the effectiveness of sublingual misoprostol for cervical ripening before diagnostic hysteroscopy in premenopausal women. DESIGN:Placebo-controlled, double-blind, randomized trial. SETTING:University hospital. PATIENT(S):Fifty-two women with an indication for diagnostic hysteroscopy. INTERVENTI...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,随机对照试验


    authors: Mulayim B,Celik NY,Onalan G,Bagis T,Zeyneloglu HB

    更新日期:2010-05-01 00:00:00

  • Sperm content of postacrosomal WW binding protein is related to fertilization outcomes in patients undergoing assisted reproductive technology.

    abstract:OBJECTIVE:To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. DESIGN:Prospective clinical and laboratory study. SETTING:University-based laboratory ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Aarabi M,Balakier H,Bashar S,Moskovtsev SI,Sutovsky P,Librach CL,Oko R

    更新日期:2014-08-01 00:00:00

  • Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity.

    abstract:OBJECTIVE:To test for an association between DNA fragmentation and head shape at high magnification in fresh motile spermatozoa. DESIGN:Observational study. SETTING:Academic tertiary care center. PATIENT(S):A total of 60 men in our assisted reproductive program. INTERVENTION(S):Quantifying sperm head shape using el...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Utsuno H,Oka K,Yamamoto A,Shiozawa T

    更新日期:2013-05-01 00:00:00

  • Evaluation of quantitative polymerase chain reaction markers for the detection of breast cancer cells in ovarian tissue stored for fertility preservation.

    abstract:OBJECTIVE:To develop molecular tools increasing the sensitivity of breast cancer micrometastases detection within ovarian tissue cryopreserved for fertility preservation. DESIGN:Expression of breast markers was evaluated by quantitative polymerase chain reaction in ovarian tissue from patients with benign or cancerous...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bockstaele L,Boulenouar S,Van Den Steen G,Dechène J,Tsepelidis S,Craciun L,Noël JC,Demeestere I

    更新日期:2015-08-01 00:00:00

  • Oocyte retrieval timing based on spontaneous luteinizing hormone surge during natural cycle in vitro fertilization treatment.

    abstract:OBJECTIVE:To determine the efficiency of oocyte retrieval (OR) timing based on the occurrence of spontaneous LH surge during natural cycle IVF (ncIVF) treatment. DESIGN:Retrospective cohort study. The cohort was divided into five subgroups according to the presumed stage of spontaneous LH surge on scheduling day (1A: ...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bodri D,Kawachiya S,Kondo M,Kato R,Matsumoto T

    更新日期:2014-04-01 00:00:00

  • Ulipristal acetate decreases transforming growth factor β3 serum and tumor tissue concentrations in patients with uterine fibroids.

    abstract:OBJECTIVE:To evaluate and compare transforming growth factor β3 (TGF-β3) serum concentration in patients with uterine fibroids (UFs) without hormone treatment, treated with ulipristal acetate (UPA), and controls; to evaluate TGF-β3 concentrations in UF tissue in patients without hormone treatment and those treated with...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Ciebiera M,Włodarczyk M,Wrzosek M,Słabuszewska-Jóźwiak A,Nowicka G,Jakiel G

    更新日期:2018-03-01 00:00:00

  • Cost-effectiveness analysis of preimplantation genetic screening and in vitro fertilization versus expectant management in patients with unexplained recurrent pregnancy loss.

    abstract:OBJECTIVE:To determine whether in vitro fertilization with preimplantation genetic screening (IVF/PGS) is cost effective compared with expectant management in achieving live birth for patients with unexplained recurrent pregnancy loss (RPL). DESIGN:Decision analytic model comparing costs and clinical outcomes. SETTIN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Murugappan G,Ohno MS,Lathi RB

    更新日期:2015-05-01 00:00:00

  • Lymphatic spread of endometriosis to pelvic sentinel lymph nodes: a prospective clinical study.

    abstract:OBJECTIVE:To establish the prevalence of endometriosis metastatic to pelvic sentinel lymph nodes (PSLN) in women with ovarian and/or peritoneal endometriosis. DESIGN:Prospective clinical study. SETTING:Academic research institution. PATIENT(S):Women with a laparoscopic diagnosis of ovarian and/or peritoneal endometr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Tempfer CB,Wenzl R,Horvat R,Grimm C,Polterauer S,Buerkle B,Reinthaller A,Huber JC

    更新日期:2011-09-01 00:00:00

  • Creation of a neovagina following Williams vaginoplasty and the Creatsas modification in 111 patients with Mayer-Rokitansky-Küster-Hauser syndrome.

    abstract:OBJECTIVE:Evaluation of the Creatsas modification of Williams vaginoplasty for the creation of neovagina in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKH syndrome). DESIGN:Record of perioperative and postoperative results and complications. Follow-up evaluations of patients yearly after the operation. S...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Creatsas G,Deligeoroglou E,Makrakis E,Kontoravdis A,Papadimitriou L

    更新日期:2001-11-01 00:00:00

  • How couples who have undergone in vitro fertilization decide what to do with surplus frozen embryos.

    abstract::In a qualitative interview study of 77 families with stored frozen embryos, we found that while embryo disposition decision making was influenced by individual life circumstances, embryo quantity/quality, personal values, embryo conceptualization, and clinic information, it was a stepwise process that could be represe...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Nachtigall RD,Mac Dougall K,Harrington J,Duff J,Lee M,Becker G

    更新日期:2009-12-01 00:00:00

  • Laparoscopic excision of recurrent endometriomas: long-term outcome and comparison with primary surgery.

    abstract:OBJECTIVE:To compare the laparoscopic excision of primary versus recurrent ovarian endometriomas. DESIGN:Descriptive study. SETTING:Tertiary referral center for the treatment of endometriosis. PATIENT(S):Between 1993 and 2002, 359 consecutive patients: 305 primary surgeries (group A) and 54 reoperations for a recurr...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Fedele L,Bianchi S,Zanconato G,Berlanda N,Raffaelli R,Fontana E

    更新日期:2006-03-01 00:00:00

  • New MCM8 mutation associated with premature ovarian insufficiency and chromosomal instability in a highly consanguineous Tunisian family.

    abstract:OBJECTIVE:To identify the gene(s) involved in the etiology of premature ovarian insufficiency in a highly consanguineous Tunisian family. DESIGN:Genetic analysis of a large consanguineous family with several affected siblings. SETTING:University hospital-based cytogenetics and molecular genetics laboratories. PATIEN...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Bouali N,Francou B,Bouligand J,Imanci D,Dimassi S,Tosca L,Zaouali M,Mougou S,Young J,Saad A,Guiochon-Mantel A

    更新日期:2017-10-01 00:00:00

  • Reconstruction of ooplasm recipient oocytes with frozen-thawed donor microcytoplasts and influence on the microtubular spindle.

    abstract:OBJECTIVE(S):To cryopreserve micromanipulated ooplast segments (microcytoplasts) from mouse oocytes, compare microcytoplast and parent or recipient oocyte fusion performed within or without the zona pellucida, compare electrofusion of fresh or frozen oocyte with frozen-thawed microcytoplasts, and assess spindle integri...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Goud AP,Goud PT,Diamond MP,Gonik B,Dozortsev DI,Hughes MR

    更新日期:2007-04-01 00:00:00

  • Intrauterine injection of human chorionic gonadotropin before embryo transfer can improve in vitro fertilization-embryo transfer outcomes: a meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To evaluate whether intrauterine injection of hCG before embryo transfer can improve IVF-ET outcomes. DESIGN:Meta-analysis. SETTING:Not applicable. PATIENT(S):Infertile women who underwent IVF-ET and received an intrauterine injection of hCG before ET. INTERVENTION(S):Infertile women treated with or witho...

    journal_title:Fertility and sterility

    pub_type: 杂志文章,meta分析,评审


    authors: Gao M,Jiang X,Li B,Li L,Duan M,Zhang X,Tian J,Qi K

    更新日期:2019-07-01 00:00:00

  • Evidence for association of the G1733A polymorphism of the androgen receptor gene with recurrent spontaneous abortions.

    abstract:OBJECTIVE:To determine whether the G1733A polymorphism of the androgen receptor gene is associated with an increased risk for recurrent spontaneous abortion (RSA). DESIGN:Case-control study. SETTING:Division of Genetics and Biotechnology, Department of Biology, University of Athens. PATIENT(S):A total of 131 women w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Karvela M,Stefanakis N,Papadopoulou S,Tsitilou SG,Tsilivakos V,Lamnissou K

    更新日期:2008-11-01 00:00:00

  • Improving posttransplantation survival of human ovarian tissue by treating the host and graft.

    abstract:OBJECTIVE:To improve posttransplantation survival of frozen-thawed human ovarian tissue in immunodeficient mice. DESIGN:Histologic study of transplanted human ovaries after treating the host and graft. SETTING:Infertility unit, university-affiliated tertiary medical center. PATIENT(S):Ovarian tissue from six girls/w...

    journal_title:Fertility and sterility

    pub_type: 杂志文章


    authors: Abir R,Fisch B,Jessel S,Felz C,Ben-Haroush A,Orvieto R

    更新日期:2011-03-15 00:00:00