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One thousand initiated cycles of in vitro fertilization in women > or = 40 years of age.

Abstract：

OBJECTIVE:To evaluate the results of IVF in women > or = 40 years of age using their own oocytes. DESIGN:Retrospective study. SETTING:Wolfson and Royal Masonic in vitro fertilization units, London, United Kingdom. PATIENT(S):A total of 1,087 IVF cycles were started in women > or = 40 years of age. INTERVENTION(S):Medical records of patient outcomes were reviewed. MAIN OUTCOME MEASURE(S):Clinical pregnancy, miscarriage, and delivery rates. RESULT(S):Of the 1,087 cycles started in 471 women > or = 40 years of age, 842 reached oocyte retrieval (77.5%) and 702 had embryos transferred (64.6%). The pregnancy rate (PR) was significantly lower in women > or = 40 years of age than in a control group of women <40 years of age (11.3% versus 28.2%). It decreased sharply in women >42 years of age, and no women >45 years of age had a child. Women > or = 40 years of age were more likely to miscarry (27% versus 12.7%). When only one embryo was available for transfer, the PR was 3.3%. When >2 embryos were available for transfer, the PR was similar whether 2 or 3 embryos were replaced. No triplet pregnancy occurred. Women > or = 40 years of age achieved a cumulative PR of 30% after three cycles with a cumulative "take home baby" rate of 21%. CONCLUSION(S):In vitro fertilization is a reasonable treatment for women <45 years of age using their own gametes. Those with a "good response" in their first attempt may be encouraged to complete three cycles with an acceptable chance of conception.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Lass A,Croucher C,Duffy S,Dawson K,Margara R,Winston RM

doi

10.1016/s0015-0282(98)00353-7

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

1030-4

issue

6

eissn

0015-0282

issn

1556-5653

pii

S0015028298003537

journal_volume

70

pub_type

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