Abstract：
:Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks, and many other cellular and noncellular components. The high heterogeneity within the tumor microenvironment (TME) remains a key obstacle in understanding and treating cancer. Understanding the dynamic functional interplay within this intricate ecosystem will provide important insights into the design of effective combinatorial strategies against cancer. Here, we present recent technical advances to explore the complexity of the TME. Then, we discuss how innate immune sensing machinery, genetic alterations of oncogenic signaling, cellular metabolism, and epigenetic factors are involved in modulating the TME. Finally, we summarize the potential strategies to boost antitumor immunity by therapeutically exploiting the TME.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Duan Q,Zhang H,Zheng J,Zhang Ldoi
10.1016/j.trecan.2020.02.022subject
Has Abstractpub_date
2020-07-01 00:00:00pages
605-618issue
7eissn
2405-8033issn
2405-8025pii
S2405-8033(20)30083-2journal_volume
6pub_type
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