Abstract：
:Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating chronic inflammation, irrespective of diverse mutations within cancer cells.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Benesch MGK,Yang Z,Tang X,Meng G,Brindley DNdoi
10.1016/j.trecan.2017.09.004subject
Has Abstractpub_date
2017-11-01 00:00:00pages
748-752issue
11eissn
2405-8033issn
2405-8025pii
S2405-8033(17)30178-4journal_volume
3pub_type
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