Abstract:
:Alternative lengthening of telomeres (ALT) is an enigmatic process that allows certain cancers to maintain telomeres in the absence of telomerase. ALT cancers are frequently defective for ATRX/DAXX, a chaperone complex that deposits histone variant H3.3 at telomeres. We propose that mutations in alpha thalassemia-mental retardation syndrome X-linked (ATRX)/death-domain associated protein (DAXX) prime ALT activation by disrupting telomeric heterochromatin.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Voon HPJ,Collas P,Wong LHdoi
10.1016/j.trecan.2016.02.003subject
Has Abstractpub_date
2016-03-01 00:00:00pages
114-116issue
3eissn
2405-8033issn
2405-8025pii
S2405-8033(16)00034-0journal_volume
2pub_type
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