Abstract：
:The Abelson (ABL) tyrosine kinases were identified as drivers of leukemia in mice and humans. Emerging data has shown a role for the ABL family kinases, ABL1 and ABL2, in the progression of several solid tumors. This review will focus on recent reports of the involvement of the ABL kinases in tumor progression using mouse models as well as recent data generated from genomic and proteomic studies linking enhanced expression and hyper-activation of the ABL kinases to some human cancers. Preclinical studies on small molecule inhibitors of the ABL kinases suggest that their use may have beneficial effects for the treatment of selected solid tumors.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Wang J,Pendergast AMdoi
10.1016/j.trecan.2015.07.004subject
Has Abstractpub_date
2015-10-01 00:00:00pages
110-123issue
2eissn
2405-8033issn
2405-8025journal_volume
1pub_type
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