Adding STING to the Tale of Oncolytic Virotherapy.

Abstract:

:The identification of STING as a key cytoplasmic innate recognition molecule for DNA viruses whose function is lost in a variety of cancers has coincided with the approval of IMLYGIC for metastatic melanoma. This represents the first replication competent viral therapy approved for the treatment of any cancer in the US. The role of STING pathway in the selectivity of HSV has been addressed for the first time in Xia et al (1).

journal_name

Trends Cancer

journal_title

Trends in cancer

authors

Thorne SH

doi

10.1016/j.trecan.2016.01.002

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

67-68

issue

2

eissn

2405-8033

issn

2405-8025

journal_volume

2

pub_type

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