Abstract：
:The pace of genomic and immunological breakthroughs in oncology is accelerating, making it likely that large randomized trials will increasingly become outdated before their completion. Traditional clinical research/practice paradigms must adapt to the reality unveiled by genomics, especially the need for customized drug combinations, rather than one-size-fits-all monotherapy. The raison-d'être of precision oncology is to offer 'the right drug for the right patient at the right time', a process enabled by transformative tissue and blood-based genomic technologies. Genomically targeted therapies are most suitable in early disease, when molecular heterogeneity is less pronounced, while immunotherapy is most effective against tumors with unstable genomes. Next-generation cancer research/practice models will need to overcome the tyranny of tradition and emphasize an innovative, precise and personalized patient-centric approach.
journal_name
Trends Cancerjournal_title
Trends in cancerauthors
Subbiah V,Kurzrock Rdoi
10.1016/j.trecan.2017.12.004subject
Has Abstractpub_date
2018-02-01 00:00:00pages
101-109issue
2eissn
2405-8033issn
2405-8025pii
S2405-8033(17)30237-6journal_volume
4pub_type
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